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Sulforaphane prevents microcystin-LR-induced oxidative damage and apoptosis in BALB/c mice
Sun, Xiaoyun; Mi, Lixin; Liu, Jin; Song, Lirong; Chung, Fung-Lung; Gan, Nanqin; Song, LR (reprint author), CAS, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu Nanlu 7, Wuhan 430072, Peoples R China; lrsong@ihb.ac.cn; gannq@ihb.ac.cn
2011
Source PublicationTOXICOLOGY AND APPLIED PHARMACOLOGY
ISSN0041-008X
Volume255Issue:1Pages:9-17
AbstractMicrocystins (MCs), the products of blooming algae Microcystis, are waterborne environmental toxins that have been implicated in the development of liver cancer, necrosis, and even fatal intrahepatic bleeding. Alternative protective approaches in addition to complete removal of MCs in drinking water are urgently needed. In our previous work, we found that sulforaphane (SFN) protects against microcystin-LR (MC-LR)-induced cytotoxicity by activating the NF-E2-related factor 2 (Nrf2)-mediated defensive response in human hepatoma (HepG2) and NIH 3T3 cells. The purpose of this study was to investigate and confirm efficacy the SFN-induced multi-mechanistic defense system against MC-induced hepatotoxicity in an animal model. We report that SFN protected against MC-LR-induced liver damage and animal death at a nontoxic and physiologically relevant dose in BALB/c mice. The protection by SFN included activities of anti-cytochrome P450 induction, anti-oxidation, anti-inflammation, and anti-apoptosis. Our results suggest that SFN may protect mice against MC-induced hepatotoxicity. This raises the possibility of a similar protective effect in human populations, particularly in developing countries where freshwaters are polluted by blooming algae. (C) 2011 Elsevier Inc. All rights reserved.
KeywordMicrocystin-lr (Mc-lr) Sulforaphane (Sfn) Nf-e2-related Factor 2 (Nrf2) Apoptosis Reactive Oxygen Species (Ros)
Department[Sun, XY; Liu, J; Song, LR; Gan, NQ] CAS, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; [Mi, LX; Chung, FL] Georgetown Univ, Dept Oncol, Lombardi Comprehens Canc Ctr, Washington, DC 20057 USA
Subject AreaPharmacology & Pharmacy ; Toxicology
Funding Organization973 program[2008CB418000]; National Natural Science Foundation of China[31070355]; Natural Science Foundation of China[U0833604]; Chinese Academy of Sciences[KZCX1-YW-14-1] ; 973 program[2008CB418000]; National Natural Science Foundation of China[31070355]; Natural Science Foundation of China[U0833604]; Chinese Academy of Sciences[KZCX1-YW-14-1] ; 973 program[2008CB418000]; National Natural Science Foundation of China[31070355]; Natural Science Foundation of China[U0833604]; Chinese Academy of Sciences[KZCX1-YW-14-1] ; 973 program[2008CB418000]; National Natural Science Foundation of China[31070355]; Natural Science Foundation of China[U0833604]; Chinese Academy of Sciences[KZCX1-YW-14-1]
Indexed BySCI
Language英语
WOS IDWOS:000293764700002
Funding Organization973 program[2008CB418000]; National Natural Science Foundation of China[31070355]; Natural Science Foundation of China[U0833604]; Chinese Academy of Sciences[KZCX1-YW-14-1] ; 973 program[2008CB418000]; National Natural Science Foundation of China[31070355]; Natural Science Foundation of China[U0833604]; Chinese Academy of Sciences[KZCX1-YW-14-1] ; 973 program[2008CB418000]; National Natural Science Foundation of China[31070355]; Natural Science Foundation of China[U0833604]; Chinese Academy of Sciences[KZCX1-YW-14-1] ; 973 program[2008CB418000]; National Natural Science Foundation of China[31070355]; Natural Science Foundation of China[U0833604]; Chinese Academy of Sciences[KZCX1-YW-14-1]
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/16371
Collection藻类生物学及应用研究中心_期刊论文
Corresponding AuthorSong, LR (reprint author), CAS, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu Nanlu 7, Wuhan 430072, Peoples R China; lrsong@ihb.ac.cn; gannq@ihb.ac.cn
Recommended Citation
GB/T 7714
Sun, Xiaoyun,Mi, Lixin,Liu, Jin,et al. Sulforaphane prevents microcystin-LR-induced oxidative damage and apoptosis in BALB/c mice[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY,2011,255(1):9-17.
APA Sun, Xiaoyun.,Mi, Lixin.,Liu, Jin.,Song, Lirong.,Chung, Fung-Lung.,...&gannq@ihb.ac.cn.(2011).Sulforaphane prevents microcystin-LR-induced oxidative damage and apoptosis in BALB/c mice.TOXICOLOGY AND APPLIED PHARMACOLOGY,255(1),9-17.
MLA Sun, Xiaoyun,et al."Sulforaphane prevents microcystin-LR-induced oxidative damage and apoptosis in BALB/c mice".TOXICOLOGY AND APPLIED PHARMACOLOGY 255.1(2011):9-17.
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