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学科主题: Pharmacology & Pharmacy; Toxicology
题名: Sulforaphane prevents microcystin-LR-induced oxidative damage and apoptosis in BALB/c mice
作者: Sun, Xiaoyun ; Mi, Lixin ; Liu, Jin ; Song, Lirong ; Chung, Fung-Lung ; Gan, Nanqin
通讯作者: Song, LR (reprint author), CAS, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu Nanlu 7, Wuhan 430072, Peoples R China ; lrsong@ihb.ac.cn ; gannq@ihb.ac.cn
关键词: Microcystin-LR (MC-LR) ; Sulforaphane (SFN) ; NF-E2-related factor 2 (Nrf2) ; Apoptosis ; Reactive oxygen species (ROS)
刊名: TOXICOLOGY AND APPLIED PHARMACOLOGY
发表日期: 2011
卷: 255, 期:1, 页:9-17
收录类别: SCI
部门归属: [Sun, XY; Liu, J; Song, LR; Gan, NQ] CAS, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; [Mi, LX; Chung, FL] Georgetown Univ, Dept Oncol, Lombardi Comprehens Canc Ctr, Washington, DC 20057 USA
资助者: 973 program[2008CB418000]; National Natural Science Foundation of China[31070355]; Natural Science Foundation of China[U0833604]; Chinese Academy of Sciences[KZCX1-YW-14-1]
摘要: Microcystins (MCs), the products of blooming algae Microcystis, are waterborne environmental toxins that have been implicated in the development of liver cancer, necrosis, and even fatal intrahepatic bleeding. Alternative protective approaches in addition to complete removal of MCs in drinking water are urgently needed. In our previous work, we found that sulforaphane (SFN) protects against microcystin-LR (MC-LR)-induced cytotoxicity by activating the NF-E2-related factor 2 (Nrf2)-mediated defensive response in human hepatoma (HepG2) and NIH 3T3 cells. The purpose of this study was to investigate and confirm efficacy the SFN-induced multi-mechanistic defense system against MC-induced hepatotoxicity in an animal model. We report that SFN protected against MC-LR-induced liver damage and animal death at a nontoxic and physiologically relevant dose in BALB/c mice. The protection by SFN included activities of anti-cytochrome P450 induction, anti-oxidation, anti-inflammation, and anti-apoptosis. Our results suggest that SFN may protect mice against MC-induced hepatotoxicity. This raises the possibility of a similar protective effect in human populations, particularly in developing countries where freshwaters are polluted by blooming algae. (C) 2011 Elsevier Inc. All rights reserved.
语种: 英语
WOS记录号: WOS:000293764700002
ISSN号: 0041-008X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/16371
Appears in Collections:藻类生物学及应用研究中心_期刊论文

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Sun, Xiaoyun; Mi, Lixin; Liu, Jin; Song, Lirong; Chung, Fung-Lung; Gan, Nanqin.Sulforaphane prevents microcystin-LR-induced oxidative damage and apoptosis in BALB/c mice,TOXICOLOGY AND APPLIED PHARMACOLOGY,2011,255(1):9-17
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