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学科主题: Life Sciences & Biomedicine - Other Topics
题名: Toxicogenomic investigation of Tetrahymena thermophila exposed to dichlorodiphenyltrichloroethane (DDT), tributyltin (TBT), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
作者: Chang Yue ; Feng LiFang ; Miao Wei
通讯作者: Miao Wei,Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China ; miaowei@ihb.ac.cn
关键词: microarray ; enrichment analysis ; gene interaction network ; pollutant
刊名: SCIENCE CHINA-LIFE SCIENCES
发表日期: 2011
卷: 54, 期:7, 页:617-625
收录类别: SCI
部门归属: [Chang, Y; Feng, LF; Miao, W] Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China; [Feng, LF] Zhejiang Gongshang Univ, Coll Food Sci & Biotechnol, Hangzhou 310035, Zhejiang, Peoples R China; [Chang, Y] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
资助者: National Natural Science Foundation of China[30870356, 31071993]; Chinese Academy of Sciences[KSCX2-YW-G-072]
摘要: Dichlorodiphenyltrichloroethane (DDT), tributyltin (TBT), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are persistent in the environment and cause continuous toxic effects in humans and aquatic life. Tetrahymena thermophila has the potential for use as a model for research regarding toxicants. In this study, this organism was used to analyze a genome-wide microarray generated from cells exposed to DDT, TBT and TCDD. To accomplish this, genes differentially expressed when treated with each toxicant were identified, after which their functions were categorized using GO enrichment analysis. The results suggested that the responses of T. thermophila were similar to those of multicellular organisms. Additionally, the context likelihood of relatedness method (CLR) was applied to construct a TCDD-relevant network. The T-shaped network obtained could be functionally divided into two subnetworks. The general functions of both subnetworks were related to the epigenetic mechanism of TCDD. Based on analysis of the networks, a model of the TCDD effect on T. thermophila was inferred. Thus, Tetrahymena has the potential to be a good unicellular eukaryotic model for toxic mechanism research at the genome level.
语种: 英语
WOS记录号: WOS:000292700100004
ISSN号: 1674-7305
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/16359
Appears in Collections:水生生物分子与细胞生物学研究中心_期刊论文

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Chang Yue; Feng LiFang; Miao Wei.Toxicogenomic investigation of Tetrahymena thermophila exposed to dichlorodiphenyltrichloroethane (DDT), tributyltin (TBT), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD),SCIENCE CHINA-LIFE SCIENCES,2011,54(7):617-625
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文件名: Toxicogenomic investigation of Tetrahymena thermophila exposed to dichlorodiphenyltrichloroethane (DDT), tributyltin (TBT), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).pdf
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