IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
Toxicogenomic investigation of Tetrahymena thermophila exposed to dichlorodiphenyltrichloroethane (DDT), tributyltin (TBT), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
Chang Yue; Feng LiFang; Miao Wei; Miao Wei,Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China; miaowei@ihb.ac.cn
2011
Source PublicationSCIENCE CHINA-LIFE SCIENCES
ISSN1674-7305
Volume54Issue:7Pages:617-625
AbstractDichlorodiphenyltrichloroethane (DDT), tributyltin (TBT), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are persistent in the environment and cause continuous toxic effects in humans and aquatic life. Tetrahymena thermophila has the potential for use as a model for research regarding toxicants. In this study, this organism was used to analyze a genome-wide microarray generated from cells exposed to DDT, TBT and TCDD. To accomplish this, genes differentially expressed when treated with each toxicant were identified, after which their functions were categorized using GO enrichment analysis. The results suggested that the responses of T. thermophila were similar to those of multicellular organisms. Additionally, the context likelihood of relatedness method (CLR) was applied to construct a TCDD-relevant network. The T-shaped network obtained could be functionally divided into two subnetworks. The general functions of both subnetworks were related to the epigenetic mechanism of TCDD. Based on analysis of the networks, a model of the TCDD effect on T. thermophila was inferred. Thus, Tetrahymena has the potential to be a good unicellular eukaryotic model for toxic mechanism research at the genome level.
KeywordMicroarray Enrichment Analysis Gene Interaction Network Pollutant
Department[Chang, Y; Feng, LF; Miao, W] Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China; [Feng, LF] Zhejiang Gongshang Univ, Coll Food Sci & Biotechnol, Hangzhou 310035, Zhejiang, Peoples R China; [Chang, Y] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
Subject AreaLife Sciences & Biomedicine - Other Topics
Funding OrganizationNational Natural Science Foundation of China[30870356, 31071993]; Chinese Academy of Sciences[KSCX2-YW-G-072] ; National Natural Science Foundation of China[30870356, 31071993]; Chinese Academy of Sciences[KSCX2-YW-G-072] ; National Natural Science Foundation of China[30870356, 31071993]; Chinese Academy of Sciences[KSCX2-YW-G-072] ; National Natural Science Foundation of China[30870356, 31071993]; Chinese Academy of Sciences[KSCX2-YW-G-072]
Indexed BySCI
Language英语
WOS IDWOS:000292700100004
Funding OrganizationNational Natural Science Foundation of China[30870356, 31071993]; Chinese Academy of Sciences[KSCX2-YW-G-072] ; National Natural Science Foundation of China[30870356, 31071993]; Chinese Academy of Sciences[KSCX2-YW-G-072] ; National Natural Science Foundation of China[30870356, 31071993]; Chinese Academy of Sciences[KSCX2-YW-G-072] ; National Natural Science Foundation of China[30870356, 31071993]; Chinese Academy of Sciences[KSCX2-YW-G-072]
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/16359
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorMiao Wei,Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China; miaowei@ihb.ac.cn
Recommended Citation
GB/T 7714
Chang Yue,Feng LiFang,Miao Wei,et al. Toxicogenomic investigation of Tetrahymena thermophila exposed to dichlorodiphenyltrichloroethane (DDT), tributyltin (TBT), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)[J]. SCIENCE CHINA-LIFE SCIENCES,2011,54(7):617-625.
APA Chang Yue,Feng LiFang,Miao Wei,Miao Wei,Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China,&miaowei@ihb.ac.cn.(2011).Toxicogenomic investigation of Tetrahymena thermophila exposed to dichlorodiphenyltrichloroethane (DDT), tributyltin (TBT), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).SCIENCE CHINA-LIFE SCIENCES,54(7),617-625.
MLA Chang Yue,et al."Toxicogenomic investigation of Tetrahymena thermophila exposed to dichlorodiphenyltrichloroethane (DDT), tributyltin (TBT), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)".SCIENCE CHINA-LIFE SCIENCES 54.7(2011):617-625.
Files in This Item:
File Name/Size DocType Version Access License
Toxicogenomic invest(613KB) 开放获取--View Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chang Yue]'s Articles
[Feng LiFang]'s Articles
[Miao Wei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chang Yue]'s Articles
[Feng LiFang]'s Articles
[Miao Wei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chang Yue]'s Articles
[Feng LiFang]'s Articles
[Miao Wei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Toxicogenomic investigation of Tetrahymena thermophila exposed to dichlorodiphenyltrichloroethane (DDT), tributyltin (TBT), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.