IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
Identification and evaluation of a panel of serum biomarkers for predicting response to thalidomide in multiple myeloma patients
Xiong, Qian; Ge, Feng; Ge, F (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China; gefeng@ihb.ac.cn
2011
Source PublicationEXPERT REVIEW OF PROTEOMICS
ISSN1478-9450
Volume8Issue:4Pages:439-442
AbstractPredicting response to thalidomide-based therapy remains a challenging task faced by clinicians in the treatment of multiple myeloma. The pioneering work reported by Rajpal et al. moves one step further towards solving this challenge. They developed a proteomics-based approach that combines immunodepletion, 2D-difference gel electrophoresis analysis and mass spectrometry to search for serum proteins with expressions that show significant correlations to thalidomide treatment. This integrated approach allowed them to identify a panel of protein biomarkers. By using ELISA-based validation and strict statistical analysis, the authors have achieved an overall 84.0% predictive accuracy, with associated sensitivity and specificity values of 81.8 and 86.2%, respectively. Their methods and significant findings are reviewed within this article. This panel of biomarkers may not only guide initial therapy, but can also provide direct implications for personalized medicine in multiple myeloma patients.
Keyword2d-dige Multiple Myeloma Predictive Biomarkers Thalidomide
Department[Xiong, Q; Ge, F] Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
Subject AreaBiochemistry & Molecular Biology
Indexed BySCI
Language英语
WOS IDWOS:000294139500008
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/16357
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorGe, F (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China; gefeng@ihb.ac.cn
Recommended Citation
GB/T 7714
Xiong, Qian,Ge, Feng,Ge, F ,et al. Identification and evaluation of a panel of serum biomarkers for predicting response to thalidomide in multiple myeloma patients[J]. EXPERT REVIEW OF PROTEOMICS,2011,8(4):439-442.
APA Xiong, Qian,Ge, Feng,Ge, F ,&gefeng@ihb.ac.cn.(2011).Identification and evaluation of a panel of serum biomarkers for predicting response to thalidomide in multiple myeloma patients.EXPERT REVIEW OF PROTEOMICS,8(4),439-442.
MLA Xiong, Qian,et al."Identification and evaluation of a panel of serum biomarkers for predicting response to thalidomide in multiple myeloma patients".EXPERT REVIEW OF PROTEOMICS 8.4(2011):439-442.
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