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学科主题: Biochemistry & Molecular Biology
题名: Identification and evaluation of a panel of serum biomarkers for predicting response to thalidomide in multiple myeloma patients
作者: Xiong, Qian ; Ge, Feng
通讯作者: Ge, F (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China ; gefeng@ihb.ac.cn
关键词: 2D-DIGE ; multiple myeloma ; predictive biomarkers ; thalidomide
刊名: EXPERT REVIEW OF PROTEOMICS
发表日期: 2011
卷: 8, 期:4, 页:439-442
收录类别: SCI
部门归属: [Xiong, Q; Ge, F] Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
摘要: Predicting response to thalidomide-based therapy remains a challenging task faced by clinicians in the treatment of multiple myeloma. The pioneering work reported by Rajpal et al. moves one step further towards solving this challenge. They developed a proteomics-based approach that combines immunodepletion, 2D-difference gel electrophoresis analysis and mass spectrometry to search for serum proteins with expressions that show significant correlations to thalidomide treatment. This integrated approach allowed them to identify a panel of protein biomarkers. By using ELISA-based validation and strict statistical analysis, the authors have achieved an overall 84.0% predictive accuracy, with associated sensitivity and specificity values of 81.8 and 86.2%, respectively. Their methods and significant findings are reviewed within this article. This panel of biomarkers may not only guide initial therapy, but can also provide direct implications for personalized medicine in multiple myeloma patients.
语种: 英语
WOS记录号: WOS:000294139500008
ISSN号: 1478-9450
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内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/16357
Appears in Collections:水生生物分子与细胞生物学研究中心_期刊论文

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Xiong, Qian; Ge, Feng.Identification and evaluation of a panel of serum biomarkers for predicting response to thalidomide in multiple myeloma patients,EXPERT REVIEW OF PROTEOMICS,2011,8(4):439-442
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文件名: Identification and evaluation of a panel of serum biomarkers for predicting response to thalidomide in multiple myeloma patients.pdf
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