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Studies on the toxic effects of microcystin-LR on the zebrafish (Danio rerio) under different temperatures
Zhang, Xuezhen; Ji, Wei; Zhang, Huan; Zhang, Wei; Xie, Ping; Xie, P (reprint author), Chinese Acad Sci, Inst Hydrobiol, Donghu Expt Stn Lake Ecosyst, State Key Lab Fresh Water Ecol & Biotechnol China, Donghu S Rd 7, Wuhan 430072, Peoples R China; xieping@ihb.ac.cn
2011
Source PublicationJOURNAL OF APPLIED TOXICOLOGY
ISSN0260-437X
Volume31Issue:6Pages:561-567
AbstractIt is well known that fish have stronger tolerance than mammals to microcystin (MC) exposure, and such a difference is attributed to their different core body temperatures. However, no in vivo study has been conducted to investigate the effects of temperature on MC-induced toxicity in fish, a typical poikilotherm. Tolerance and detoxification response of zebrafish treated with MC-LR were investigated under three temperatures. The LD(50) values evidently increased with a decline of the temperature (547, 260 and 176 mu g kg(-1) at 12,22 and 32 degrees C, respectively), indicating stronger tolerance of the fish at lower temperatures. Changes in the transcription of glutathione S-transferase (GST) isoforms in the fish were observed, and their sensitivity of response in the transcription of GST mRNA was on the order of 12 > 32 > 22 degrees C. We screened out several GST genes which were more delicate to solve the MC-LR exposure at different temperatures, i.e. GST rho1, al, p1 and theta1 in the 12 degrees C group, and GST zeta1 and p2 in the 22 and 32 degrees C groups. Our findings partly validate the hypothesis that high temperature enhances toxic effects of MCs on poikilotherms. Our studies also indicate that temperature-dependent toxic effects should be taken into account for field toxic assessment of microcystins in fish. Copyright (C) 2010 John Wiley & Sons, Ltd.
KeywordMicrocystin-lr Temperature Ld(50) Glutathione S-transferases Real-time Pcr Zebrafish
Department[Ji, W; Zhang, W; Xie, P] Chinese Acad Sci, Inst Hydrobiol, Donghu Expt Stn Lake Ecosyst, State Key Lab Fresh Water Ecol & Biotechnol China, Wuhan 430072, Peoples R China; [Zhang, XZ; Zhang, H; Zhang, W; Xie, P] Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China; [Zhang, XZ; Zhang, H; Zhang, W; Xie, P] Minist Educ, Key Lab Agr Anim Genet Breeding & Reprod, Wuhan 430070, Peoples R China
Subject AreaToxicology
Funding OrganizationHuazhong Agricultural University; Ministry of Science and Technology of the People's Republic of China[2007BAC26B02] ; Huazhong Agricultural University; Ministry of Science and Technology of the People's Republic of China[2007BAC26B02] ; Huazhong Agricultural University; Ministry of Science and Technology of the People's Republic of China[2007BAC26B02] ; Huazhong Agricultural University; Ministry of Science and Technology of the People's Republic of China[2007BAC26B02]
Indexed BySCI
Language英语
WOS IDWOS:000294744900008
Funding OrganizationHuazhong Agricultural University; Ministry of Science and Technology of the People's Republic of China[2007BAC26B02] ; Huazhong Agricultural University; Ministry of Science and Technology of the People's Republic of China[2007BAC26B02] ; Huazhong Agricultural University; Ministry of Science and Technology of the People's Republic of China[2007BAC26B02] ; Huazhong Agricultural University; Ministry of Science and Technology of the People's Republic of China[2007BAC26B02]
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Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/16277
Collection淡水生态学研究中心_期刊论文
Corresponding AuthorXie, P (reprint author), Chinese Acad Sci, Inst Hydrobiol, Donghu Expt Stn Lake Ecosyst, State Key Lab Fresh Water Ecol & Biotechnol China, Donghu S Rd 7, Wuhan 430072, Peoples R China; xieping@ihb.ac.cn
Recommended Citation
GB/T 7714
Zhang, Xuezhen,Ji, Wei,Zhang, Huan,et al. Studies on the toxic effects of microcystin-LR on the zebrafish (Danio rerio) under different temperatures[J]. JOURNAL OF APPLIED TOXICOLOGY,2011,31(6):561-567.
APA Zhang, Xuezhen.,Ji, Wei.,Zhang, Huan.,Zhang, Wei.,Xie, Ping.,...&xieping@ihb.ac.cn.(2011).Studies on the toxic effects of microcystin-LR on the zebrafish (Danio rerio) under different temperatures.JOURNAL OF APPLIED TOXICOLOGY,31(6),561-567.
MLA Zhang, Xuezhen,et al."Studies on the toxic effects of microcystin-LR on the zebrafish (Danio rerio) under different temperatures".JOURNAL OF APPLIED TOXICOLOGY 31.6(2011):561-567.
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