IHB OpenIR  > 淡水生态学研究中心  > 期刊论文
Anemia Induced by Repeated Exposure to Cyanobacterial Extracts with Explorations of Underlying Mechanisms
Zhang, Xuezhen; Xie, Ping; Li, Dapeng; Shi, Zechao; Wang, Jun; Yuan, Gailing; Zhao, Yanyan; Tang, Rong; Xie, P (reprint author), Huazhong Agr Univ, Coll Fisheries, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430070, Peoples R China; xieping@ihb.ac.cn
2011
Source PublicationENVIRONMENTAL TOXICOLOGY
ISSN1520-4081
Volume26Issue:5Pages:472-479
AbstractHematological abnormalities or derangements have been demonstrated in patients suffering form microcystins (MCs) in hemodialysis unit in Caruaru, Brazil, 1996. While experimental study on hematological effect of microcystins has been rare and the underlying mechanisms are still puzzling. In the present study, microcystins were repeatedly intraperitoneally injected with a dose of 6 mu g/kg/day in rabbits (Oryctolagus cuniculus) for 14 days, and the prolonged effects of extracted microcystins on hematotoxicology were investigated. Significant decreases were observed in the hematological indices red blood cell counts, hematocrit, hemoglobin, and platelet count, while an obvious anemia occurred in rabbits after 14-day exposure. Moreover, red blood cell volume distribution width, mean corpuscular volume, and mean corpuscular hemoglobin did not vary significantly, indicating that rabbits suffered from normocytic anemia. In bone marrow, on the 14th day after toxin exposure, the frequency of micronucleus increased significantly, and the viability of bone marrow cells decreased markedly compared with the control. Serum erythropoietin levels declined on the 7th and 14th day, which suggested that the ability to regulate differentiation and maturation of erythrocytes was impaired. These results indicate that repeated exposure of microcystins can result in normocyte anemia, and the bone marrow injures and the sharp decreases of erythropoietin levels were responsible for the anemia. (C) 2011 Wiley Periodicals, Inc. Environ Toxicol 26: 472-479, 2011.
KeywordMicrocystins Anemia Bone Marrow Erythropoietin Hematotoxicology
Department[Zhang, XZ; Xie, P; Li, DP; Wang, J; Yuan, GL; Zhao, YY; Tang, R] Huazhong Agr Univ, Coll Fisheries, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430070, Peoples R China; [Xie, P] Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan 430072, Peoples R China; [Shi, ZC] Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Jinzhou 434000, Peoples R China
Subject AreaEnvironmental Sciences & Ecology ; Toxicology ; Water Resources
Funding OrganizationNational Natural Science Foundation of China[30800160]; State Key Laboratory of Freshwater Ecology and Biotechnology[2008FB015]; Huazhong Agricultural University ; National Natural Science Foundation of China[30800160]; State Key Laboratory of Freshwater Ecology and Biotechnology[2008FB015]; Huazhong Agricultural University ; National Natural Science Foundation of China[30800160]; State Key Laboratory of Freshwater Ecology and Biotechnology[2008FB015]; Huazhong Agricultural University ; National Natural Science Foundation of China[30800160]; State Key Laboratory of Freshwater Ecology and Biotechnology[2008FB015]; Huazhong Agricultural University
Indexed BySCI
Language英语
WOS IDWOS:000295035600005
Funding OrganizationNational Natural Science Foundation of China[30800160]; State Key Laboratory of Freshwater Ecology and Biotechnology[2008FB015]; Huazhong Agricultural University ; National Natural Science Foundation of China[30800160]; State Key Laboratory of Freshwater Ecology and Biotechnology[2008FB015]; Huazhong Agricultural University ; National Natural Science Foundation of China[30800160]; State Key Laboratory of Freshwater Ecology and Biotechnology[2008FB015]; Huazhong Agricultural University ; National Natural Science Foundation of China[30800160]; State Key Laboratory of Freshwater Ecology and Biotechnology[2008FB015]; Huazhong Agricultural University
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/16265
Collection淡水生态学研究中心_期刊论文
Corresponding AuthorXie, P (reprint author), Huazhong Agr Univ, Coll Fisheries, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430070, Peoples R China; xieping@ihb.ac.cn
Recommended Citation
GB/T 7714
Zhang, Xuezhen,Xie, Ping,Li, Dapeng,et al. Anemia Induced by Repeated Exposure to Cyanobacterial Extracts with Explorations of Underlying Mechanisms[J]. ENVIRONMENTAL TOXICOLOGY,2011,26(5):472-479.
APA Zhang, Xuezhen.,Xie, Ping.,Li, Dapeng.,Shi, Zechao.,Wang, Jun.,...&xieping@ihb.ac.cn.(2011).Anemia Induced by Repeated Exposure to Cyanobacterial Extracts with Explorations of Underlying Mechanisms.ENVIRONMENTAL TOXICOLOGY,26(5),472-479.
MLA Zhang, Xuezhen,et al."Anemia Induced by Repeated Exposure to Cyanobacterial Extracts with Explorations of Underlying Mechanisms".ENVIRONMENTAL TOXICOLOGY 26.5(2011):472-479.
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