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学科主题: Life Sciences & Biomedicine - Other Topics
题名: Molecular variation and evolution of the tyrosine kinase domains of insulin receptor IRa and IRb genes in Cyprinidae
作者: Kong XiangHui ; Wang XuZhen ; He ShunPing
通讯作者: Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China ; clad@ihb.ac.cn
关键词: insulin receptor gene ; tyrosine kinase domain ; Cyprinidae
刊名: SCIENCE CHINA-LIFE SCIENCES
发表日期: 2011
卷: 54, 期:7, 页:626-633
收录类别: SCI
部门归属: [Kong, XH; Wang, XZ; He, SP] Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China; [Kong, XH] Henan Normal Univ, Coll Life Sci, Xinxiang 453007, Peoples R China
资助者: National Natural Science Foundation of China[30770299, 30530120]; Development Plan of the State Key Fundamental Research of China[2004CB117402]
摘要: The insulin receptor (IR) gene plays an important role in regulating cell growth, differentiation and development. In the present study, DNA sequences of insulin receptor genes, IRa and IRb, were amplified and sequenced from 37 representative species of the Cyprinidae and from five outgroup species from non-cyprinid Cypriniformes. Based on coding sequences (CDS) of tyrosine kinase regions of IRa and IRb, molecular evolution and phylogenetic relationships were analyzed to better understand the characteristics of IR gene divergence in the family Cyprinidae. IRa and IRb were clustered into one lineage in the gene tree of the IR gene family, reconstructed using the unweighted pair group method with arithmetic mean (UPGMA). IRa and IRb have evolved into distinct genes after IR gene duplication in Cyprinidae. For each gene, molecular evolution analyses showed that there was no significant difference among different groups in the reconstructed maximum parsimony (MP) tree of Cyprinidae; IRa and IRb have been subjected to similar evolutionary pressure among different lineages. Although the amino acid sequences of IRa and IRb tyrosine kinase regions were highly conserved, our analyses showed that there were clear sequence variations between the tyrosine kinase regions of IRa and IRb proteins. This indicates that IRa and IRb proteins might play different roles in the insulin signaling pathway.
语种: 英语
WOS记录号: WOS:000292700100005
ISSN号: 1674-7305
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/16259
Appears in Collections:水生生物多样性与资源保护研究中心_期刊论文

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Kong XiangHui; Wang XuZhen; He ShunPing.Molecular variation and evolution of the tyrosine kinase domains of insulin receptor IRa and IRb genes in Cyprinidae,SCIENCE CHINA-LIFE SCIENCES,2011,54(7):626-633
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文件名: Molecular variation and evolution of the tyrosine kinase domains of insulin receptor IRa and IRb genes in Cyprinidae.pdf
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