IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
非洲爪蟾中一种长型肽聚糖识别蛋白的克隆与表达分析(英文)
齐志涛; 张启焕; 王资生; 王爱民; 黄贝; 昌鸣先; 聂品
2011
Source Publication动物学研究
ISSN0254-5853
Issue4
Abstract肽聚糖识别蛋白(peptidoglycan recognition proteins,PGRPs)是固有免疫系统中一类重要的模式识别受体。该文首次从两栖类模式生物-非洲爪蟾(Xenopus tropicalis)中克隆得到了一个长型PGRP(XtPGRP-L)基因。XtPGRP-L具有5个外显子和4个内含子的基因组结构,该结构在进化的过程中比较保守。序列比对与系统进化分析显示XtPGRP-L具有保守的酰胺酶活性位点。蛋白质建模显示XtPGRP-L拥有保守的3-D结构。实时定量PCR检测显示,XtPGRP-L在非洲爪蟾胚胎早期不表达,到72h蝌蚪期开始表达。在成体的肝脏、肺、肠和胃高表达。同时,在LPS刺激后,XtPGRP-L在肝脏、肠和胃中呈明显上调表达。结果表明,XtPGRP-L在非洲爪蟾固有免疫系统中可能具有重要的作用。
Keyword肽聚糖识别蛋白 基因克隆 表达分析 非洲爪蟾
Department盐城工学院海洋技术系;盐城工学院化学与生物工程学院生物实验中心;中国科学院水生生物研究所淡水生态与生物技术国家重点实验室
Funding Organizationsupported by the Project from the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (10KJB240001); the Foundation for Talent Recruitment of Yancheng Institute of Technology (XKR2011007); the National Natural Science Foundation of China (30830083) ; supported by the Project from the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (10KJB240001); the Foundation for Talent Recruitment of Yancheng Institute of Technology (XKR2011007); the National Natural Science Foundation of China (30830083) ; supported by the Project from the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (10KJB240001); the Foundation for Talent Recruitment of Yancheng Institute of Technology (XKR2011007); the National Natural Science Foundation of China (30830083) ; supported by the Project from the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (10KJB240001); the Foundation for Talent Recruitment of Yancheng Institute of Technology (XKR2011007); the National Natural Science Foundation of China (30830083)
Indexed ByCSCD
Language中文
Funding Organizationsupported by the Project from the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (10KJB240001); the Foundation for Talent Recruitment of Yancheng Institute of Technology (XKR2011007); the National Natural Science Foundation of China (30830083) ; supported by the Project from the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (10KJB240001); the Foundation for Talent Recruitment of Yancheng Institute of Technology (XKR2011007); the National Natural Science Foundation of China (30830083) ; supported by the Project from the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (10KJB240001); the Foundation for Talent Recruitment of Yancheng Institute of Technology (XKR2011007); the National Natural Science Foundation of China (30830083) ; supported by the Project from the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (10KJB240001); the Foundation for Talent Recruitment of Yancheng Institute of Technology (XKR2011007); the National Natural Science Foundation of China (30830083)
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/16063
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Recommended Citation
GB/T 7714
齐志涛,张启焕,王资生,等. 非洲爪蟾中一种长型肽聚糖识别蛋白的克隆与表达分析(英文)[J]. 动物学研究,2011(4).
APA 齐志涛.,张启焕.,王资生.,王爱民.,黄贝.,...&聂品.(2011).非洲爪蟾中一种长型肽聚糖识别蛋白的克隆与表达分析(英文).动物学研究(4).
MLA 齐志涛,et al."非洲爪蟾中一种长型肽聚糖识别蛋白的克隆与表达分析(英文)".动物学研究 .4(2011).
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