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学科主题: Multidisciplinary Sciences
题名: Acute and chronic un-ionized ammonia toxicity to 'all-fish' growth hormone transgenic common carp (Cyprinus carpio L.)
作者: Guan Bo1, 2; Hu Wei1; Zhang TangLin1; Duan Ming1, 2; Li DeLiang1, 2; Wang YaPing1; Zhu ZuoYan1
通讯作者: Hu, W, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China ; huwei@ihb.ac.cn
关键词: transgenic common carp ; growth hormone ; un-ionized ammonia ; toxicity ; mortality
刊名: CHINESE SCIENCE BULLETIN
发表日期: 2010-12-01
DOI: 10.1007/s11434-010-4165-5
卷: 55, 期:35, 页:4032-4036
收录类别: SCI
文章类型: Article
部门归属: [Guan Bo; Hu Wei; Zhang TangLin; Duan Ming; Li DeLiang; Wang YaPing; Zhu ZuoYan] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; [Guan Bo; Duan Ming; Li DeLiang] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
WOS标题词: Science & Technology
资助者: National Basic Research Program of China [2007CB109205, 2009CB118804]; National Natural Science Foundation of China [30623001]
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
摘要: Ammonia is toxic to fish in natural and artificial waters. We evaluated the acute (96 h) and chronic (21 d) toxicity of un-ionized ammonia to GH transgenic common carp (Cyprinus carpio L.) and non-transgenic common carp using a static-renewal bioassay. The 24, 48, 72 and 96 h median lethal concentrations (LC50) of un-ionized ammonia were slightly lower in transgenic carp (2.64, 2.44, 2.28 and 2.16 mg N/L, respectively) than in non-transgenic carp (2.70, 2.64, 2.52 and 2.33 mg N/L, respectively). Similarly, the median lethal time (LT50) was significantly shorter for transgenic carp (1.41, 7.91 and 117.42 h) than for non-transgenic common carp (2.53, 14.06 and 150.44 h) following exposure to 3.86, 3.29, or 2.09 mg N/L, respectively. Moreover, the mortality of transgenic carp was significantly higher than that of non-transgenic carp at all un-ionized ammonia concentrations ((0.91 +/- 0.12), (0.48 +/- 0.06) and (0.12 +/- 0.01) mg N/L) during the 21 d chronic toxicity test. Our results suggest that GH transgenic carp are less tolerant of un-ionized ammonia than non-transgenic carp. Our data are useful for evaluating potential environmental risk, optimizing stocking density in intensive aquaculture and establishing water quality criteria for ammonia in aquaculture.
英文摘要: Ammonia is toxic to fish in natural and artificial waters. We evaluated the acute (96 h) and chronic (21 d) toxicity of un-ionized ammonia to GH transgenic common carp (Cyprinus carpio L.) and non-transgenic common carp using a static-renewal bioassay. The 24, 48, 72 and 96 h median lethal concentrations (LC(50)) of un-ionized ammonia were slightly lower in transgenic carp (2.64, 2.44, 2.28 and 2.16 mg N/L, respectively) than in non-transgenic carp (2.70, 2.64, 2.52 and 2.33 mg N/L, respectively). Similarly, the median lethal time (LT(50)) was significantly shorter for transgenic carp (1.41, 7.91 and 117.42 h) than for non-transgenic common carp (2.53, 14.06 and 150.44 h) following exposure to 3.86, 3.29, or 2.09 mg N/L, respectively. Moreover, the mortality of transgenic carp was significantly higher than that of non-transgenic carp at all un-ionized ammonia concentrations ((0.91 +/- 0.12), (0.48 +/- 0.06) and (0.12 +/- 0.01) mg N/L) during the 21 d chronic toxicity test. Our results suggest that GH transgenic carp are less tolerant of un-ionized ammonia than non-transgenic carp. Our data are useful for evaluating potential environmental risk, optimizing stocking density in intensive aquaculture and establishing water quality criteria for ammonia in aquaculture.
关键词[WOS]: TILAPIA OREOCHROMIS-NILOTICUS ; ONCORHYNCHUS-MYKISS ; RAINBOW-TROUT ; RECEPTOR ; EXPOSURE ; RAT ; SUSCEPTIBILITY ; TRANSCRIPTS ; PERFORMANCE ; EXPRESSION
语种: 英语
WOS记录号: WOS:000285196000009
ISSN号: 1001-6538
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/15634
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

Recommended Citation:
Guan Bo; Hu Wei; Zhang TangLin; Duan Ming; Li DeLiang; Wang YaPing; Zhu ZuoYan.Acute and chronic un-ionized ammonia toxicity to 'all-fish' growth hormone transgenic common carp (Cyprinus carpio L.),CHINESE SCIENCE BULLETIN,2010,55(35):4032-4036
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