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Acute Effects of Microcystins on the Transcription of 14 Glutathione S-Transferase Isoforms in Wistar Rat
Li, Guangyu; Xie, Ping; Li, Huiying; Hao, Le; Xiong, Qian; Qiu, Tong; Liu, Ying; Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Donghu South Rd 7, Wuhan 430072, Peoples R China; xieping@ihb.ac.cn
2011
Source PublicationENVIRONMENTAL TOXICOLOGY
ISSN1520-4081
Volume26Issue:2Pages:187-194
AbstractThe glutathione S-transferases (GST) play important roles in the detoxification of microcystins (MCs). For better understanding of the responses of GST isforms to MCs exposure, informations about the effects of MCs on GSTs are necessary. In this experiment, we cloned the full length cDNA of 14 GST isoforms (GST alpha, kappa, mu, omega, pi, theta, zeta, and microsomal GST) from Wistar rat. The mRNA abundance of each rat GST isoform in the liver, kidney, and testis was analyzed by real time quantitative PCR. Multiple GST isoforms were constitutively expressed in all examined organs, but some isoforms were expressed at higher level in one organ than in others. The relative changes of the mRNA abundance in the liver, kidney, and testis of Wiatar rat i.v. injected with crude MCs extract at dose of 1LD(50) were also analyzed. Generally, the expression of most GSTs in the liver and testis was suppressed while that in kidney was induced after being injected with MCs. It is suggested that the transcription of GST isoforms varied in different ways within an organ and between organs of Wistar rat exposed to MCs. (c) 2009 Wiley Periodicals, Inc. Environ Toxicol 26: 187-194, 2011.
KeywordMicrocystin Glutathione S-transferases Real Time Pcr Gene Expression Wistar Rat
Department[Li, Guangyu; Xie, Ping; Li, Huiying; Hao, Le; Xiong, Qian; Qiu, Tong; Liu, Ying] Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan 430072, Peoples R China
Subject AreaEnvironmental Sciences ; Toxicology ; Water Resources
Funding OrganizationNational Natural Science Foundation of China [30700077, 30530170] ; National Natural Science Foundation of China [30700077, 30530170] ; National Natural Science Foundation of China [30700077, 30530170] ; National Natural Science Foundation of China [30700077, 30530170]
Indexed BySCI
Language英语
WOS IDWOS:000288652000009
Funding OrganizationNational Natural Science Foundation of China [30700077, 30530170] ; National Natural Science Foundation of China [30700077, 30530170] ; National Natural Science Foundation of China [30700077, 30530170] ; National Natural Science Foundation of China [30700077, 30530170]
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/15606
Collection淡水生态学研究中心_期刊论文
Corresponding AuthorXie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Donghu South Rd 7, Wuhan 430072, Peoples R China; xieping@ihb.ac.cn
Recommended Citation
GB/T 7714
Li, Guangyu,Xie, Ping,Li, Huiying,et al. Acute Effects of Microcystins on the Transcription of 14 Glutathione S-Transferase Isoforms in Wistar Rat[J]. ENVIRONMENTAL TOXICOLOGY,2011,26(2):187-194.
APA Li, Guangyu.,Xie, Ping.,Li, Huiying.,Hao, Le.,Xiong, Qian.,...&xieping@ihb.ac.cn.(2011).Acute Effects of Microcystins on the Transcription of 14 Glutathione S-Transferase Isoforms in Wistar Rat.ENVIRONMENTAL TOXICOLOGY,26(2),187-194.
MLA Li, Guangyu,et al."Acute Effects of Microcystins on the Transcription of 14 Glutathione S-Transferase Isoforms in Wistar Rat".ENVIRONMENTAL TOXICOLOGY 26.2(2011):187-194.
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