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学科主题: Environmental Sciences; Toxicology; Water Resources
题名: Acute Effects of Microcystins on the Transcription of 14 Glutathione S-Transferase Isoforms in Wistar Rat
作者: Li, Guangyu ; Xie, Ping ; Li, Huiying ; Hao, Le ; Xiong, Qian ; Qiu, Tong ; Liu, Ying
通讯作者: Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Donghu South Rd 7, Wuhan 430072, Peoples R China ; xieping@ihb.ac.cn
关键词: microcystin ; glutathione S-transferases ; real time PCR ; gene expression ; Wistar rat
刊名: ENVIRONMENTAL TOXICOLOGY
发表日期: 2011
卷: 26, 期:2, 页:187-194
收录类别: SCI
部门归属: [Li, Guangyu; Xie, Ping; Li, Huiying; Hao, Le; Xiong, Qian; Qiu, Tong; Liu, Ying] Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan 430072, Peoples R China
资助者: National Natural Science Foundation of China [30700077, 30530170]
摘要: The glutathione S-transferases (GST) play important roles in the detoxification of microcystins (MCs). For better understanding of the responses of GST isforms to MCs exposure, informations about the effects of MCs on GSTs are necessary. In this experiment, we cloned the full length cDNA of 14 GST isoforms (GST alpha, kappa, mu, omega, pi, theta, zeta, and microsomal GST) from Wistar rat. The mRNA abundance of each rat GST isoform in the liver, kidney, and testis was analyzed by real time quantitative PCR. Multiple GST isoforms were constitutively expressed in all examined organs, but some isoforms were expressed at higher level in one organ than in others. The relative changes of the mRNA abundance in the liver, kidney, and testis of Wiatar rat i.v. injected with crude MCs extract at dose of 1LD(50) were also analyzed. Generally, the expression of most GSTs in the liver and testis was suppressed while that in kidney was induced after being injected with MCs. It is suggested that the transcription of GST isoforms varied in different ways within an organ and between organs of Wistar rat exposed to MCs. (c) 2009 Wiley Periodicals, Inc. Environ Toxicol 26: 187-194, 2011.
语种: 英语
WOS记录号: WOS:000288652000009
ISSN号: 1520-4081
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/15606
Appears in Collections:淡水生态学研究中心_期刊论文

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Li, Guangyu; Xie, Ping; Li, Huiying; Hao, Le; Xiong, Qian; Qiu, Tong; Liu, Ying.Acute Effects of Microcystins on the Transcription of 14 Glutathione S-Transferase Isoforms in Wistar Rat,ENVIRONMENTAL TOXICOLOGY,2011,26(2):187-194
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