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Involment of p53, Bax, and Bcl-2 Pathway in Microcystins-Induced Apoptosis in Rat Testis
Li, Guang-Yu; Xie, Ping; Li, Hui-Ying; Hao, Le; Xiong, Qian; Qiu, Tong; Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Donghu South Rd 7, Wuhan 430072, Peoples R China; xieping@ihb.ac.cn
2011
Source PublicationENVIRONMENTAL TOXICOLOGY
ISSN1520-4081
Volume26Issue:2Pages:111-117
AbstractIt has been reported that microcystins (MCs) could accumulate in the gonads of mammals and MCs exposure exerts obvious toxic effects on male reproductive system of mammals. We have comfirmed that MCs could accumulate and induce apoptosis in rat testis. The p53, Bax, and Bcl-2 protein play important roles in mitochondria-dependent apoptotic pathway, and this study aimed to investigate whether the p53, Bax, and Bcl-2 pathway is involved in microcystins-induced apoptosis in rat testis and discussed the possible mechanisms. Our results show that MCs led to persistent increase of transcriptional and protein level of P53 and Bax expression but led to decrease of Bcl-2 expression, resulting in an increased ratio of Bax to Bcl-2, which might contribute to apoptotic cell death of rat testis following MCs treatment. The increased ratio of expression of Bax to that of Bcl-2 induced by MCs suggests their important role in MCs-induced apoptosis in rat testis tissue. (c) 2009 Wiley Periodicals, Inc. Environ Toxicol 26: 111-117, 2011.
KeywordMicrocystin Apoptosis Real Time Pcr Wistar Rat Bcl-2 Bax P53
Department[Li, Guang-Yu; Xie, Ping; Li, Hui-Ying; Hao, Le; Xiong, Qian; Qiu, Tong] Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan 430072, Peoples R China
Subject AreaEnvironmental Sciences ; Toxicology ; Water Resources
Funding OrganizationNational Basic Research Program of China (973 Program) [2008CB418101] ; National Basic Research Program of China (973 Program) [2008CB418101] ; National Basic Research Program of China (973 Program) [2008CB418101] ; National Basic Research Program of China (973 Program) [2008CB418101]
Indexed BySCI
Language英语
WOS IDWOS:000288652000001
Funding OrganizationNational Basic Research Program of China (973 Program) [2008CB418101] ; National Basic Research Program of China (973 Program) [2008CB418101] ; National Basic Research Program of China (973 Program) [2008CB418101] ; National Basic Research Program of China (973 Program) [2008CB418101]
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/15602
Collection淡水生态学研究中心_期刊论文
Corresponding AuthorXie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Donghu South Rd 7, Wuhan 430072, Peoples R China; xieping@ihb.ac.cn
Recommended Citation
GB/T 7714
Li, Guang-Yu,Xie, Ping,Li, Hui-Ying,et al. Involment of p53, Bax, and Bcl-2 Pathway in Microcystins-Induced Apoptosis in Rat Testis[J]. ENVIRONMENTAL TOXICOLOGY,2011,26(2):111-117.
APA Li, Guang-Yu.,Xie, Ping.,Li, Hui-Ying.,Hao, Le.,Xiong, Qian.,...&xieping@ihb.ac.cn.(2011).Involment of p53, Bax, and Bcl-2 Pathway in Microcystins-Induced Apoptosis in Rat Testis.ENVIRONMENTAL TOXICOLOGY,26(2),111-117.
MLA Li, Guang-Yu,et al."Involment of p53, Bax, and Bcl-2 Pathway in Microcystins-Induced Apoptosis in Rat Testis".ENVIRONMENTAL TOXICOLOGY 26.2(2011):111-117.
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