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学科主题: Environmental Sciences; Toxicology; Water Resources
题名: Involment of p53, Bax, and Bcl-2 Pathway in Microcystins-Induced Apoptosis in Rat Testis
作者: Li, Guang-Yu ; Xie, Ping ; Li, Hui-Ying ; Hao, Le ; Xiong, Qian ; Qiu, Tong
通讯作者: Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Donghu South Rd 7, Wuhan 430072, Peoples R China ; xieping@ihb.ac.cn
关键词: microcystin ; apoptosis ; real time PCR ; Wistar rat ; Bcl-2 ; Bax ; P53
刊名: ENVIRONMENTAL TOXICOLOGY
发表日期: 2011
卷: 26, 期:2, 页:111-117
收录类别: SCI
部门归属: [Li, Guang-Yu; Xie, Ping; Li, Hui-Ying; Hao, Le; Xiong, Qian; Qiu, Tong] Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan 430072, Peoples R China
资助者: National Basic Research Program of China (973 Program) [2008CB418101]
摘要: It has been reported that microcystins (MCs) could accumulate in the gonads of mammals and MCs exposure exerts obvious toxic effects on male reproductive system of mammals. We have comfirmed that MCs could accumulate and induce apoptosis in rat testis. The p53, Bax, and Bcl-2 protein play important roles in mitochondria-dependent apoptotic pathway, and this study aimed to investigate whether the p53, Bax, and Bcl-2 pathway is involved in microcystins-induced apoptosis in rat testis and discussed the possible mechanisms. Our results show that MCs led to persistent increase of transcriptional and protein level of P53 and Bax expression but led to decrease of Bcl-2 expression, resulting in an increased ratio of Bax to Bcl-2, which might contribute to apoptotic cell death of rat testis following MCs treatment. The increased ratio of expression of Bax to that of Bcl-2 induced by MCs suggests their important role in MCs-induced apoptosis in rat testis tissue. (c) 2009 Wiley Periodicals, Inc. Environ Toxicol 26: 111-117, 2011.
语种: 英语
WOS记录号: WOS:000288652000001
ISSN号: 1520-4081
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/15602
Appears in Collections:淡水生态学研究中心_期刊论文

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Li, Guang-Yu; Xie, Ping; Li, Hui-Ying; Hao, Le; Xiong, Qian; Qiu, Tong.Involment of p53, Bax, and Bcl-2 Pathway in Microcystins-Induced Apoptosis in Rat Testis,ENVIRONMENTAL TOXICOLOGY,2011,26(2):111-117
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