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Genome-wide identification and evolution of ATP-binding cassette transporters in the ciliate Tetrahymena thermophila: A case of functional divergence in a multigene family
Xiong, Jie; Feng, Lifang; Yuan, Dongxia; Fu, Chengjie; Miao, Wei; Fu, CJ, Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China; cjfu1981@gmail.com, miaowei530@yeah.net
2010
Source PublicationBMC EVOLUTIONARY BIOLOGY
ISSN1471-2148
Volume10Pages:330-
AbstractBackground: In eukaryotes, ABC transporters that utilize the energy of ATP hydrolysis to expel cellular substrates into the environment are responsible for most of the efflux from cells. Many members of the superfamily of ABC transporters have been linked with resistance to multiple drugs or toxins. Owing to their medical and toxicological importance, members of the ABC superfamily have been studied in several model organisms and warrant examination in newly sequenced genomes. Results: A total of 165 ABC transporter genes, constituting a highly expanded superfamily relative to its size in other eukaryotes, were identified in the macronuclear genome of the ciliate Tetrahymena thermophila. Based on ortholog comparisons, phylogenetic topologies and intron characterizations, each highly expanded ABC transporter family of T. thermophila was classified into several distinct groups, and hypotheses about their evolutionary relationships are presented. A comprehensive microarray analysis revealed divergent expression patterns among the members of the ABC transporter superfamily during different states of physiology and development. Many of the relatively recently formed duplicate pairs within individual ABC transporter families exhibit significantly different expression patterns. Further analysis showed that multiple mechanisms have led to functional divergence that is responsible for the preservation of duplicated genes. Conclusion: Gene duplications have resulted in an extensive expansion of the superfamily of ABC transporters in the Tetrahymena genome, making it the largest example of its kind reported in any organism to date. Multiple independent duplications and subsequent divergence contributed to the formation of different families of ABC transporter genes. Many of the members within a gene family exhibit different expression patterns. The combination of gene duplication followed by both sequence divergence and acquisition of new patterns of expression likely plays a role in the adaptation of Tetrahymen a to its environment.
Department[Fu, Chengjie] Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China; [Xiong, Jie; Feng, Lifang; Yuan, Dongxia; Miao, Wei] Chinese Acad Sci, Key Lab Aquat Biodivers & Conservat, Inst Hydrobiol, Wuhan 430072, Peoples R China; [Fu, Chengjie] Evolutionary Biol Ctr, Program Systemat Biol, S-75236 Uppsala, Sweden; [Feng, Lifang] Zhejiang Gongshang Univ, Coll Food Sci & Biotechnol, Hangzhou 310035, Zhejiang, Peoples R China; [Xiong, Jie; Feng, Lifang] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
Subject AreaEvolutionary Biology ; Genetics & Heredity
Funding OrganizationCAS [KSCX2-YW-G-072]; National Natural Science Foundation of China [30870356, 30970424]; National Institutes of Health [GM021793, GM072752] ; CAS [KSCX2-YW-G-072]; National Natural Science Foundation of China [30870356, 30970424]; National Institutes of Health [GM021793, GM072752] ; CAS [KSCX2-YW-G-072]; National Natural Science Foundation of China [30870356, 30970424]; National Institutes of Health [GM021793, GM072752] ; CAS [KSCX2-YW-G-072]; National Natural Science Foundation of China [30870356, 30970424]; National Institutes of Health [GM021793, GM072752]
Indexed BySCI
Language英语
WOS IDWOS:000285339400003
Funding OrganizationCAS [KSCX2-YW-G-072]; National Natural Science Foundation of China [30870356, 30970424]; National Institutes of Health [GM021793, GM072752] ; CAS [KSCX2-YW-G-072]; National Natural Science Foundation of China [30870356, 30970424]; National Institutes of Health [GM021793, GM072752] ; CAS [KSCX2-YW-G-072]; National Natural Science Foundation of China [30870356, 30970424]; National Institutes of Health [GM021793, GM072752] ; CAS [KSCX2-YW-G-072]; National Natural Science Foundation of China [30870356, 30970424]; National Institutes of Health [GM021793, GM072752]
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/15532
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorFu, CJ, Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China; cjfu1981@gmail.com, miaowei530@yeah.net
Recommended Citation
GB/T 7714
Xiong, Jie,Feng, Lifang,Yuan, Dongxia,et al. Genome-wide identification and evolution of ATP-binding cassette transporters in the ciliate Tetrahymena thermophila: A case of functional divergence in a multigene family[J]. BMC EVOLUTIONARY BIOLOGY,2010,10:330-.
APA Xiong, Jie.,Feng, Lifang.,Yuan, Dongxia.,Fu, Chengjie.,Miao, Wei.,...&cjfu1981@gmail.com, miaowei530@yeah.net.(2010).Genome-wide identification and evolution of ATP-binding cassette transporters in the ciliate Tetrahymena thermophila: A case of functional divergence in a multigene family.BMC EVOLUTIONARY BIOLOGY,10,330-.
MLA Xiong, Jie,et al."Genome-wide identification and evolution of ATP-binding cassette transporters in the ciliate Tetrahymena thermophila: A case of functional divergence in a multigene family".BMC EVOLUTIONARY BIOLOGY 10(2010):330-.
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