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学科主题: Biochemistry & Molecular Biology; Biophysics
题名: Proteomics: addressing the challenges of multiple myeloma
作者: Ge, Feng ; Tao, Shengce ; Bi, Lijun ; Zhang, Zhiping ; Zhang, Xian'En
通讯作者: Ge, F, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China ; gefeng@ihb.ac.cn, x.zhang@wh.iov.cn
关键词: proteomics ; multiple myeloma ; biomarkers ; mass spectrometry ; post-translational modifications
刊名: ACTA BIOCHIMICA ET BIOPHYSICA SINICA
发表日期: 2011
卷: 43, 期:2, 页:89-95
收录类别: SCI
部门归属: [Ge, Feng] Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China; [Tao, Shengce] Shanghai Jiao Tong Univ, Minist Educ, Key Lab Syst Biomed, Shanghai Ctr Syst Biomed, Shanghai 200240, Peoples R China; [Bi, Lijun] Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China; [Zhang, Zhiping; Zhang, Xian'En] Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Peoples R China
资助者: Chinese Academy of Sciences ; National Protein Research Fund [2009CB825400, 2006CB910902]; Ministry of Health of China [2008ZX10003-005]; State Key Development Program for Basic Research of China [2010CB529205]; Program for New Century Excellent Talents in University [NCET-09-551]
摘要: Multiple myeloma (MM) is a malignancy of terminally differentiated B-lymphocytes that accounts for similar to 13% of all hematologic cancers. Despite a wealth of knowledge describing the molecular biology of MM as well as significant advances in therapeutics, this disease remains incurable. Since proteins govern the cellular structure and biological function, a wide selection of proteomic approaches holds great promise for increasing our understanding of this disease, such as by investigating the dynamic nature of protein expression, cellular and subcellular distribution, post-translational modifications, and interactions at both the cellular and subcellular levels. The aims of this review are to introduce the available and emerging proteomic technologies that have potential applications in the study of MM and to highlight the current status of proteomic studies of MM. To date, although there have been a limited number of proteomic studies in MM, those performed have provided valuable information with regard to MM diagnosis and therapy. The potential future application of proteomic technologies is expected to provide new avenues in MM diagnostics, individualized therapy design and therapy response surveillance for the clinician.
语种: 英语
WOS记录号: WOS:000286670900001
ISSN号: 1672-9145
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/15524
Appears in Collections:水生生物分子与细胞生物学研究中心_期刊论文

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Ge, Feng; Tao, Shengce; Bi, Lijun; Zhang, Zhiping; Zhang, Xian'En.Proteomics: addressing the challenges of multiple myeloma,ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2011,43(2):89-95
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