IHB OpenIR  > 水生生物分子与细胞生物学研究中心  > 期刊论文
Enhanced hyperplasia in muscles of transgenic zebrafish expressing Follistatin1
Li Xi; Nie Fen; Yin Zhan; He JiangYan; He, JY, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China; jyhe@ihb.ac.cn
2011
Source PublicationSCIENCE CHINA-LIFE SCIENCES
ISSN1674-7305
Volume54Issue:2Pages:159-165
AbstractMyostatin is a member of the transforming growth factor-beta (TGF-beta) super-family and functions as a negative regulator of muscle growth. Binding of the specific receptor, Activin receptor IIB (Act RIIB), with myostatin or other related TGF-beta members, could be inhibited by the activin-binding protein follistatin (Fst) in mammals. Overexpressing Fst in mouse skeletal muscle leads to muscle hypertrophy and hyperplasia. To determine if Fst has similar roles in fish, we generated transgenic zebrafish expressing high levels of zebrafish Fst1 using the promoter of the zebrafish skeletal muscle-specific gene, myosin, light polypeptide 2, skeletal muscle (Mylz2). Independent transgenic zebrafish lines exhibited elevated expression levels of myogenic regulatory genes MyoD and Pax7 in muscle cells. Adult Fst1 overexpressing transgenic zebrafish exhibited a slight body weight increase. The high level of Fst1 expression dramatically increased myofiber numbers in skeletal muscle, without significantly changing the fiber size. Our findings suggest that Fst1 overexpression can promote zebrafish muscle growth by enhancing myofiber hyperplasia.
KeywordFollistatin1 Myostatin Muscle Growth Transgenic Zebrafish
Department[Li Xi; Nie Fen; Yin Zhan; He JiangYan] Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
Subject AreaBiology
Funding OrganizationNational Natural Science Foundation of China [30671600]; National Basic Research Program of China [2010CB126302, 2009CB118701] ; National Natural Science Foundation of China [30671600]; National Basic Research Program of China [2010CB126302, 2009CB118701] ; National Natural Science Foundation of China [30671600]; National Basic Research Program of China [2010CB126302, 2009CB118701] ; National Natural Science Foundation of China [30671600]; National Basic Research Program of China [2010CB126302, 2009CB118701]
Indexed BySCI
Language英语
WOS IDWOS:000287702200008
Funding OrganizationNational Natural Science Foundation of China [30671600]; National Basic Research Program of China [2010CB126302, 2009CB118701] ; National Natural Science Foundation of China [30671600]; National Basic Research Program of China [2010CB126302, 2009CB118701] ; National Natural Science Foundation of China [30671600]; National Basic Research Program of China [2010CB126302, 2009CB118701] ; National Natural Science Foundation of China [30671600]; National Basic Research Program of China [2010CB126302, 2009CB118701]
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/15520
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorHe, JY, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China; jyhe@ihb.ac.cn
Recommended Citation
GB/T 7714
Li Xi,Nie Fen,Yin Zhan,et al. Enhanced hyperplasia in muscles of transgenic zebrafish expressing Follistatin1[J]. SCIENCE CHINA-LIFE SCIENCES,2011,54(2):159-165.
APA Li Xi,Nie Fen,Yin Zhan,He JiangYan,He, JY, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China,&jyhe@ihb.ac.cn.(2011).Enhanced hyperplasia in muscles of transgenic zebrafish expressing Follistatin1.SCIENCE CHINA-LIFE SCIENCES,54(2),159-165.
MLA Li Xi,et al."Enhanced hyperplasia in muscles of transgenic zebrafish expressing Follistatin1".SCIENCE CHINA-LIFE SCIENCES 54.2(2011):159-165.
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