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学科主题: Biology
题名: Enhanced hyperplasia in muscles of transgenic zebrafish expressing Follistatin1
作者: Li Xi ; Nie Fen ; Yin Zhan ; He JiangYan
通讯作者: He, JY, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China ; jyhe@ihb.ac.cn
关键词: Follistatin1 ; myostatin ; muscle growth ; transgenic ; zebrafish
刊名: SCIENCE CHINA-LIFE SCIENCES
发表日期: 2011
卷: 54, 期:2, 页:159-165
收录类别: SCI
部门归属: [Li Xi; Nie Fen; Yin Zhan; He JiangYan] Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
资助者: National Natural Science Foundation of China [30671600]; National Basic Research Program of China [2010CB126302, 2009CB118701]
摘要: Myostatin is a member of the transforming growth factor-beta (TGF-beta) super-family and functions as a negative regulator of muscle growth. Binding of the specific receptor, Activin receptor IIB (Act RIIB), with myostatin or other related TGF-beta members, could be inhibited by the activin-binding protein follistatin (Fst) in mammals. Overexpressing Fst in mouse skeletal muscle leads to muscle hypertrophy and hyperplasia. To determine if Fst has similar roles in fish, we generated transgenic zebrafish expressing high levels of zebrafish Fst1 using the promoter of the zebrafish skeletal muscle-specific gene, myosin, light polypeptide 2, skeletal muscle (Mylz2). Independent transgenic zebrafish lines exhibited elevated expression levels of myogenic regulatory genes MyoD and Pax7 in muscle cells. Adult Fst1 overexpressing transgenic zebrafish exhibited a slight body weight increase. The high level of Fst1 expression dramatically increased myofiber numbers in skeletal muscle, without significantly changing the fiber size. Our findings suggest that Fst1 overexpression can promote zebrafish muscle growth by enhancing myofiber hyperplasia.
语种: 英语
WOS记录号: WOS:000287702200008
ISSN号: 1674-7305
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/15520
Appears in Collections:水生生物分子与细胞生物学研究中心_期刊论文

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Li Xi; Nie Fen; Yin Zhan; He JiangYan.Enhanced hyperplasia in muscles of transgenic zebrafish expressing Follistatin1,SCIENCE CHINA-LIFE SCIENCES,2011,54(2):159-165
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