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学科主题: Biochemical Research Methods; Biochemistry & Molecular Biology
题名: Proteomic analysis of multiple myeloma: Current status and future perspectives
作者: Ge, Feng ; Bi, Li-Jun ; Tao, Sheng-Ce ; Xu, Xu-dong ; Zhang, Zhi-Ping ; Kitazato, Kaio ; Zhang, Xian-En
通讯作者: Ge, F, Wuhan Univ, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China ; gefeng@ihb.ac.cn, x.zhang@wh.iov.cn
关键词: Biomarkers ; MS ; Multiple myeloma ; Proteomics ; PTM
刊名: PROTEOMICS CLINICAL APPLICATIONS
发表日期: 2011
卷: 5, 期:40545, 页:30-37
收录类别: SCI
部门归属: [Ge, Feng; Xu, Xu-dong] Wuhan Univ, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China; [Bi, Li-Jun] Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100080, Peoples R China; [Tao, Sheng-Ce] Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Shanghai 200030, Peoples R China; [Zhang, Zhi-Ping; Zhang, Xian-En] Chinese Acad Sci, State Key Lab Virol, Wuhan Inst Virol, Wuhan, Hubei, Peoples R China; [Kitazato, Kaio] Nagasaki Univ, Dept Mol Microbiol & Immunol, Nagasaki 852, Japan
资助者: Chinese Academy of Sciences ; National Protein Research Fund [2009CB825400, 2006CB910902]; Ministry of Health of China [2008ZX10003-005, 2009ZX10004-107]; Slate Key Development Program for Basic Research of China [2010CB529205]; Program for New Century Excellent Talents in University [NCET-09-551]
摘要: Multiple myeloma (MM) is a malignant plasma cell neoplasm that accounts for slightly more than 10% of all hematologic cancers and remains incurable. The major challenge remains the identification of better diagnosis and prognostic biomarkers. The advent of proteomic technologies creates new opportunities and challenges for those seeking to gain greater understanding of MM. Although there is a limited number of proteomic studies to date in MM, those performed highlight the potential impact of these technologies in our understanding of MM pathogenesis and the identification of novel therapeutic targets. In this review, we introduce the proteomic technologies available for the study of MM, summarize results of the published proteomic studies on MM, and discuss the novel developments and applications for the analysis of protein PTM in MM. The application of proteomic technologies will be valuable to better understand the pathogenesis of MM and may in the future open novel avenues in the treatment of MM.
语种: 英语
ISSN号: 1862-8346
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/15516
Appears in Collections:水生生物分子与细胞生物学研究中心_期刊论文

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Ge, Feng; Bi, Li-Jun; Tao, Sheng-Ce; Xu, Xu-dong; Zhang, Zhi-Ping; Kitazato, Kaio; Zhang, Xian-En.Proteomic analysis of multiple myeloma: Current status and future perspectives,PROTEOMICS CLINICAL APPLICATIONS,2011,5(1-2):30-37
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