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Effects of Prochloraz or Propylthiouracil on the Cross-Talk between the HPG, HPA, and HPT Axes in Zebrafish
Liu, Chunsheng; Zhang, Xiaowei; Deng, Jun; Hecker, Markus; Al-Khedhairy, Abdulaziz; Giesy, John P.; Zhou, Bingsheng; Zhou, BS, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; bszhou@ihb.ac.cn
2011
Source PublicationENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN0013-936X
Volume45Issue:2Pages:769-775
AbstractThe objective of this study was to assess chemical-induced effects on cross-talk among the hypothalamic-pituitary-gonad (HPG), hypothalamic-pituitary-adrenal (HPA), and hypothalamic-pituitary-thyroid (HPT) axes of fish. Adult female zebrafish were exposed to 300 mu g/L prochloraz (PCZ) or 100 mg/L propylthiouracil (PTU), and the transcriptional profiles of the HPG, HPA, and HPT axes were examined. Exposure to PCZ decreased plasma testosterone (T) and 17 beta-estradiol (E2) concentrations and affected HPA and HPT axes by down-regulating corticotrophin-releasing hormone (CRH) after 12 and 48 h. By using correlation analyses, it was found that the decrease in E2 plasma concentrations caused by PCZ was correlated with the down-regulation of CRH mRNA expression. Exposure to PTU resulted in lesser concentrations of thyroxine (14) and triiodothyronine (T3), greater concentrations of follicle stimulating hormone (FSH) and luteinizing hormone (LH) peptides, and increase in steroidogenic gene expression after 12 and 48 h. Concentrations of FSH and LH were negatively correlated with concentrations of 14 and T3. These results are consistent with the hypothesis that increased steroidogenic gene expression after Pill exposure resulted from a reduction in T4 and 13 concentrations, which resulted in greater secretion of FSH and LH.
Department[Liu, Chunsheng; Deng, Jun; Zhou, Bingsheng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; [Zhang, Xiaowei] Nanjing Univ, State Key Lab Pollut Control & Resource Reuse, Nanjing 210008, Peoples R China; [Zhang, Xiaowei] Nanjing Univ, Sch Environm, Nanjing 210008, Peoples R China; [Giesy, John P.] Univ Saskatchewan, Toxicol Ctr, Saskatoon, SK, Canada; [Hecker, Markus; Giesy, John P.] ENTRIX Inc, Saskatoon, SK, Canada; [Al-Khedhairy, Abdulaziz] King Saud Univ, Coll Sci, Dept Zool, Riyadh 11451, Saudi Arabia; [Giesy, John P.] Biomed Sci Univ Saskatchewan, Dept Vet, Saskatoon, SK, Canada
Subject AreaEngineering, Environmental ; Environmental Sciences
Funding OrganizationNSFC of China [20890113]; FEBL project [2008FBZ10]; NSERC of Canada [326415-07]; Western Economic Diversification Canada [6578, 6807]; Canada Research Chair program ; NSFC of China [20890113]; FEBL project [2008FBZ10]; NSERC of Canada [326415-07]; Western Economic Diversification Canada [6578, 6807]; Canada Research Chair program ; NSFC of China [20890113]; FEBL project [2008FBZ10]; NSERC of Canada [326415-07]; Western Economic Diversification Canada [6578, 6807]; Canada Research Chair program ; NSFC of China [20890113]; FEBL project [2008FBZ10]; NSERC of Canada [326415-07]; Western Economic Diversification Canada [6578, 6807]; Canada Research Chair program
Indexed BySCI
Language英语
WOS IDWOS:000286090500066
Funding OrganizationNSFC of China [20890113]; FEBL project [2008FBZ10]; NSERC of Canada [326415-07]; Western Economic Diversification Canada [6578, 6807]; Canada Research Chair program ; NSFC of China [20890113]; FEBL project [2008FBZ10]; NSERC of Canada [326415-07]; Western Economic Diversification Canada [6578, 6807]; Canada Research Chair program ; NSFC of China [20890113]; FEBL project [2008FBZ10]; NSERC of Canada [326415-07]; Western Economic Diversification Canada [6578, 6807]; Canada Research Chair program ; NSFC of China [20890113]; FEBL project [2008FBZ10]; NSERC of Canada [326415-07]; Western Economic Diversification Canada [6578, 6807]; Canada Research Chair program
Citation statistics
Cited Times:75[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/15512
Collection水环境工程研究中心_期刊论文
Corresponding AuthorZhou, BS, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; bszhou@ihb.ac.cn
Recommended Citation
GB/T 7714
Liu, Chunsheng,Zhang, Xiaowei,Deng, Jun,et al. Effects of Prochloraz or Propylthiouracil on the Cross-Talk between the HPG, HPA, and HPT Axes in Zebrafish[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2011,45(2):769-775.
APA Liu, Chunsheng.,Zhang, Xiaowei.,Deng, Jun.,Hecker, Markus.,Al-Khedhairy, Abdulaziz.,...&bszhou@ihb.ac.cn.(2011).Effects of Prochloraz or Propylthiouracil on the Cross-Talk between the HPG, HPA, and HPT Axes in Zebrafish.ENVIRONMENTAL SCIENCE & TECHNOLOGY,45(2),769-775.
MLA Liu, Chunsheng,et al."Effects of Prochloraz or Propylthiouracil on the Cross-Talk between the HPG, HPA, and HPT Axes in Zebrafish".ENVIRONMENTAL SCIENCE & TECHNOLOGY 45.2(2011):769-775.
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