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Acute Effects of Microcystins Exposure on the Transcription of Antioxidant Enzyme Genes in Three Organs (Liver, Kidney, and Testis) of Male Wistar Rats
Xiong, Qian; Xie, Ping; Li, Huiying; Hao, Le; Li, Guangyu; Qiu, Tong; Liu, Ying; Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan 430072, Peoples R China; xieping@ihb.ac.cn
2010
Source PublicationJOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
ISSN1095-6670
Volume24Issue:6Pages:361-367
AbstractMicrocystins (MCs) induce the production of reactive oxygen species (ROS) in various tissues in mammals, whereas the endogenous antioxidant enzymes are responsible to scavenge the ROS. ROS can modulate the antioxidant enzyme activities by regulating the mRNA levels. The present study was undertaken to find out the relationship between the transcriptional alterations of antioxidant enzymes and MCs stimulation in rats. The time-dependent changes of relative transcription abundance of catalase (CAT), Mn-superoxide dismutase (Mn-SOD), Cu,Zn-superoxide dismutase (Cu,Zn-SOD), glutathione reductase (GR), glutathione peroxidase (GPx), and gamma-glutamylcysteine synthetase (gamma-GCS) were investigated in three organs (liver, kidney, and testis) of male Wistar rats injected intravenously (i.v.) with 80 mu g MC-LRequivalent/kg body weight using the quantitative real-time PCR (qPCR) method. We found that MCs could affect the transcriptional activities of these antioxidant enzymes in liver, kidney, and testis of MCs-treated rats and we speculated the possible causation of the transcriptional change. The altered transcription of antioxidant enzymes may play an important role in counteracting the potential deleterious effects of elevated oxidative stress induced by MCs, and this will provide us new insights into the possible role of antioxidant enzymes in the toxicological mechanisms of MCs at molecular level. (C) 2010 Wiley Periodicals, Inc. J Biochem Mol Toxicol 24:361-367, 2010; View this article online at wileyonlinelibrary.com. DOI 10;1002/jbt.20347
KeywordMicrocystin Antioxidant Enzyme Wistar Rat Quantitative Real-time Pcr Oxidative Stress
Department[Xiong, Qian; Xie, Ping; Li, Huiying; Hao, Le; Li, Guangyu; Qiu, Tong; Liu, Ying] Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan 430072, Peoples R China; [Xiong, Qian; Hao, Le; Li, Guangyu; Qiu, Tong; Liu, Ying] Chinese Acad Sci, Grad Sch, Wuhan 430072, Peoples R China
Subject AreaBiochemistry & Molecular Biology ; Toxicology
Funding OrganizationNational Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30623001] ; National Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30623001] ; National Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30623001] ; National Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30623001]
Indexed BySCI
Language英语
WOS IDWOS:000286154800003
Funding OrganizationNational Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30623001] ; National Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30623001] ; National Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30623001] ; National Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30623001]
Citation statistics
Cited Times:39[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/15480
Collection淡水生态学研究中心_期刊论文
Corresponding AuthorXie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan 430072, Peoples R China; xieping@ihb.ac.cn
Recommended Citation
GB/T 7714
Xiong, Qian,Xie, Ping,Li, Huiying,et al. Acute Effects of Microcystins Exposure on the Transcription of Antioxidant Enzyme Genes in Three Organs (Liver, Kidney, and Testis) of Male Wistar Rats[J]. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY,2010,24(6):361-367.
APA Xiong, Qian.,Xie, Ping.,Li, Huiying.,Hao, Le.,Li, Guangyu.,...&xieping@ihb.ac.cn.(2010).Acute Effects of Microcystins Exposure on the Transcription of Antioxidant Enzyme Genes in Three Organs (Liver, Kidney, and Testis) of Male Wistar Rats.JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY,24(6),361-367.
MLA Xiong, Qian,et al."Acute Effects of Microcystins Exposure on the Transcription of Antioxidant Enzyme Genes in Three Organs (Liver, Kidney, and Testis) of Male Wistar Rats".JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY 24.6(2010):361-367.
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