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Comparative Studies on the pH Dependence of DOW of Microcystin-RR and -LR using LC-MS
Liang, Gaodao; Xie, Ping; Chen, Jun; Yu, Ting; Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan, Peoples R China; xieping@ihb.ac.cn, chenjun@ihb.ac.cn
2011
Source PublicationTHESCIENTIFICWORLDJOURNAL
ISSN1537-744X
Volume11Pages:20-26
AbstractMicrocystins (MCs) are well known worldwide as hepatotoxins produced by cyanobacteria, but little is known about the physicochemical properties of these compounds. The dependence of the n-octanol/water distribution ratio (DOW) of MC-RR and -LR to pH was measured by high-performance liquid chromatography combined with mass spectrometry (LC-MS). There was a remarkable difference in such relationships between MC-RR and -LR. The log DOW of MC-LR decreased from 1.63 at pH 1.0 to -1.26 at pH 6.5, and stabilized between -1.04 and -1.56 at a pH of 6.5 similar to 12.0; log DOW of MC-RR varied between -1.24 and -0.67 at a pH of 1.00 similar to 4.00, and stabilized between -1.20 and -1.54 at a pH of 4.00 similar to 12.00. The difference of hydrophobicity in acidic condition between MC-RR and -LR is important, not only for the analytical method of both toxins, but perhaps also for understanding the difference of toxicity to animals between the two toxins.
KeywordMcrocystins N-octanol/water Distribution Ratio Ph
Department[Liang, Gaodao; Xie, Ping; Chen, Jun; Yu, Ting] Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan, Peoples R China; [Liang, Gaodao] Wuhan Ctr Dis Prevent & Control, Wuhan, Peoples R China
Subject AreaEnvironmental Sciences ; Multidisciplinary Sciences
Funding OrganizationNational Natural Science Foundation of China [30623001]; National Basic Research Program of China (973 Program) [2008CB418101] ; National Natural Science Foundation of China [30623001]; National Basic Research Program of China (973 Program) [2008CB418101] ; National Natural Science Foundation of China [30623001]; National Basic Research Program of China (973 Program) [2008CB418101] ; National Natural Science Foundation of China [30623001]; National Basic Research Program of China (973 Program) [2008CB418101]
Indexed BySCI
Language英语
WOS IDWOS:000286474700002
Funding OrganizationNational Natural Science Foundation of China [30623001]; National Basic Research Program of China (973 Program) [2008CB418101] ; National Natural Science Foundation of China [30623001]; National Basic Research Program of China (973 Program) [2008CB418101] ; National Natural Science Foundation of China [30623001]; National Basic Research Program of China (973 Program) [2008CB418101] ; National Natural Science Foundation of China [30623001]; National Basic Research Program of China (973 Program) [2008CB418101]
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Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/15474
Collection淡水生态学研究中心_期刊论文
Corresponding AuthorXie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan, Peoples R China; xieping@ihb.ac.cn, chenjun@ihb.ac.cn
Recommended Citation
GB/T 7714
Liang, Gaodao,Xie, Ping,Chen, Jun,et al. Comparative Studies on the pH Dependence of DOW of Microcystin-RR and -LR using LC-MS[J]. THESCIENTIFICWORLDJOURNAL,2011,11:20-26.
APA Liang, Gaodao,Xie, Ping,Chen, Jun,Yu, Ting,Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan, Peoples R China,&xieping@ihb.ac.cn, chenjun@ihb.ac.cn.(2011).Comparative Studies on the pH Dependence of DOW of Microcystin-RR and -LR using LC-MS.THESCIENTIFICWORLDJOURNAL,11,20-26.
MLA Liang, Gaodao,et al."Comparative Studies on the pH Dependence of DOW of Microcystin-RR and -LR using LC-MS".THESCIENTIFICWORLDJOURNAL 11(2011):20-26.
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