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学科主题: Environmental Sciences; Multidisciplinary Sciences
题名: Comparative Studies on the pH Dependence of DOW of Microcystin-RR and -LR using LC-MS
作者: Liang, Gaodao ; Xie, Ping ; Chen, Jun ; Yu, Ting
通讯作者: Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan, Peoples R China ; xieping@ihb.ac.cn, chenjun@ihb.ac.cn
关键词: mcrocystins ; n-octanol/water distribution ratio ; pH
刊名: THESCIENTIFICWORLDJOURNAL
发表日期: 2011
卷: 11, 页:20-26
收录类别: SCI
部门归属: [Liang, Gaodao; Xie, Ping; Chen, Jun; Yu, Ting] Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan, Peoples R China; [Liang, Gaodao] Wuhan Ctr Dis Prevent & Control, Wuhan, Peoples R China
资助者: National Natural Science Foundation of China [30623001]; National Basic Research Program of China (973 Program) [2008CB418101]
摘要: Microcystins (MCs) are well known worldwide as hepatotoxins produced by cyanobacteria, but little is known about the physicochemical properties of these compounds. The dependence of the n-octanol/water distribution ratio (DOW) of MC-RR and -LR to pH was measured by high-performance liquid chromatography combined with mass spectrometry (LC-MS). There was a remarkable difference in such relationships between MC-RR and -LR. The log DOW of MC-LR decreased from 1.63 at pH 1.0 to -1.26 at pH 6.5, and stabilized between -1.04 and -1.56 at a pH of 6.5 similar to 12.0; log DOW of MC-RR varied between -1.24 and -0.67 at a pH of 1.00 similar to 4.00, and stabilized between -1.20 and -1.54 at a pH of 4.00 similar to 12.00. The difference of hydrophobicity in acidic condition between MC-RR and -LR is important, not only for the analytical method of both toxins, but perhaps also for understanding the difference of toxicity to animals between the two toxins.
语种: 英语
WOS记录号: WOS:000286474700002
ISSN号: 1537-744X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/15474
Appears in Collections:淡水生态学研究中心_期刊论文

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Liang, Gaodao; Xie, Ping; Chen, Jun; Yu, Ting.Comparative Studies on the pH Dependence of DOW of Microcystin-RR and -LR using LC-MS,THESCIENTIFICWORLDJOURNAL,2011,11():20-26
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文件名: Comparative Studies on the pH Dependence of DOW of Microcystin-RR and -LR using LC-MS.pdf
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