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Structure and expression pattern of teleost caspase recruitment domain (CARD) containing proteins that are potentially involved in NF-kappa B signalling
Chang, M. X.; Chen, W. Q.; Nie, P.; Nie, P, Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei Province, Peoples R China
2010
Source PublicationDEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
Volume34Issue:1Pages:40556
AbstractCaspase-associated recruitment domain (CARD) proteins play critical roles in regulation of caspase activation, or regulation of NF-kappa B activation. In the present study, 9 CARD-genes, which may be involved in NF-kappa B activation, were identified in teleost fish. Phylogenetic analysis showed that the orthologs to mammalian RIPK2, NOD1, PYCARD, CARD9, CARD10, CARD11, CARD14, NOD2 and BCL10 were evident in teleost fish, but clear orthologs to mammalian CARD6 and CARD8 were not found in teleost fish. In zebrafish, most CARD-genes were expressed in embryos and larvae. In adult zebrafish, zfRIPK2, zfNOD1, zfPYCARD, zfCARD9 and zfNOD2 transcripts were constitutively expressed in kidney, gill, intestine, liver, brain and spleen whilst zfCARD11, zfCARD14 and BCL10 exhibited limited tissue distribution. A CARD-related gene (zfCARD-rel), containing a single CARD domain, was identified in the zebrafish genome and the EST databases and its transcripts were detected only in spleen and kidney. Phylogenetic analysis suggested that zfCARD-rel might be the ortholog of mammalian CARD8 or the short isoform of NLRP1. Overexpression of zfCARD-rel had a significantly inhibitory effect on NF-kappa B activity, demonstrating the zfCARD-rel protein might serve as a negative regulator of cell death and inflammatory response. (C) 2009 Elsevier Ltd. All rights reserved.
KeywordCard Genes Genome Expression Nf-kappa b Activation Teleost Fish
Department[Chang, M. X.; Chen, W. Q.; Nie, P.] Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei Province, Peoples R China; [Chang, M. X.; Chen, W. Q.; Nie, P.] Chinese Acad Sci, Lab Fish Dis, Inst Hydrobiol, Wuhan 430072, Hubei Province, Peoples R China; [Chen, W. Q.] Huazhong Agr Univ, Coll Anim Sci & Vet Med, Wuhan 430070, Hubei Province, Peoples R China
Subject AreaImmunology ; Zoology
Funding OrganizationNational Natural Science Foundation of China [30830083]; Chinese Academy of Sciences [KSCX2-YW-N-021] ; National Natural Science Foundation of China [30830083]; Chinese Academy of Sciences [KSCX2-YW-N-021] ; National Natural Science Foundation of China [30830083]; Chinese Academy of Sciences [KSCX2-YW-N-021] ; National Natural Science Foundation of China [30830083]; Chinese Academy of Sciences [KSCX2-YW-N-021]
Indexed BySCI
Language英语
WOS IDWOS:000272088500001
Funding OrganizationNational Natural Science Foundation of China [30830083]; Chinese Academy of Sciences [KSCX2-YW-N-021] ; National Natural Science Foundation of China [30830083]; Chinese Academy of Sciences [KSCX2-YW-N-021] ; National Natural Science Foundation of China [30830083]; Chinese Academy of Sciences [KSCX2-YW-N-021] ; National Natural Science Foundation of China [30830083]; Chinese Academy of Sciences [KSCX2-YW-N-021]
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Cited Times:29[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/14426
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorNie, P, Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei Province, Peoples R China
Recommended Citation
GB/T 7714
Chang, M. X.,Chen, W. Q.,Nie, P.,et al. Structure and expression pattern of teleost caspase recruitment domain (CARD) containing proteins that are potentially involved in NF-kappa B signalling[J]. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,2010,34(1):40556.
APA Chang, M. X.,Chen, W. Q.,Nie, P.,&Nie, P, Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei Province, Peoples R China.(2010).Structure and expression pattern of teleost caspase recruitment domain (CARD) containing proteins that are potentially involved in NF-kappa B signalling.DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY,34(1),40556.
MLA Chang, M. X.,et al."Structure and expression pattern of teleost caspase recruitment domain (CARD) containing proteins that are potentially involved in NF-kappa B signalling".DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 34.1(2010):40556.
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