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Developmental expression of steroidogenic factor-1, cyp19a1a and cyp19a1b from common carp (Cyprinus carpio)
Tang, Bin; Hu, Wei; Hao, Jun; Zhu, Zuoyan; Hu, W, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2010
Conference Name2nd International Symposium for Fish Growth and Reporduction
Source PublicationGENERAL AND COMPARATIVE ENDOCRINOLOGY
Pages408-416
Conference DateJUN 20-21, 2009
Conference PlaceHong Kong, PEOPLES R CHINA
Publication PlaceSAN DIEGO
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
ISSN0016-6480
Department[Tang, Bin; Hu, Wei; Zhu, Zuoyan] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; [Tang, Bin; Hao, Jun; Zhu, Zuoyan] Wuhan Univ, Coll Life Sci, Wuhan 430072, Peoples R China
AbstractSteroidogenic factor-1 (SF-1), cyp19a1a and cyp19a1b play pivotal roles in vertebrate steroidogenesis and reproduction. In this study, a SF-1 cDNA (EU022463) was cloned from common carp (Cyprinus carpio). The transcript contains a 1509 base pair (bp) open reading frame (ORF) encoding a 503 amino acid sequence. Comparisons of deduced amino acid sequences demonstrated that carp SF-1 is highly homologous with those of other vertebrates. Tissue specific expressions of SF-1, cyp19a1a and cyp19a1b mRNA were analyzed in 10-month-old carp. SF-1 was abundant in the hypothalamus, pituitary, gonad, spleen and liver (females only). Cyp19a1b was preferentially expressed in the brain of both sexes but also was present at much lower levels in testis, ovary and kidney (females only). Although cyp19a1a expression was preferentially expressed in ovaries, it was also present at much lower levels in brain, testis, kidney and spleen (males only). Northern blot analysis revealed that testes and brains of both sexes expressed a transcript of about 2.8 kb in size. The expression pattern of SF-1, cyp19a1a and cyp19a1b in carp gonads suggested their involvement in sexual development. In 3-month-old carp, SF-1 and cyp19a1b were expressed highly in testes but were at much lower levels in ovaries, while the opposite pattern was observed with cyp19a1a expression. In 10-month-old carp, SF-1 expression was much higher in testes than in ovaries, while the opposite pattern was observed with cyp19a1a expression. These developmental expression patterns in carp gonads suggest important roles of SF-1 and cyp19a1b in testis development and of cyp19a1a in ovary development. (C) 2010 Elsevier Inc. All rights reserved.
KeywordSf-1 Cyp19a1a Cyp19a1b Developmental Expression Gonad Development
Indexed BySCI
Language英语
WOS IDWOS:000278875100011
Citation statistics
Document Type会议论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/13876
Collection鱼类生物学及渔业生物技术研究中心_会议论文
Corresponding AuthorHu, W, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Tang, Bin,Hu, Wei,Hao, Jun,et al. Developmental expression of steroidogenic factor-1, cyp19a1a and cyp19a1b from common carp (Cyprinus carpio)[C]. SAN DIEGO:ACADEMIC PRESS INC ELSEVIER SCIENCE,2010:408-416.
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