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Tumor suppressor U19/EAF2 regulates thrombospondin-1 expression via p53
Su, F.; Pascal, L. E.; Xiao, W.; Wang, Z.; Wang, Z, Univ Pittsburgh, Sch Med, Inst Canc, Dept Urol, 5200 Ctr Ave,Suite G40, Pittsburgh, PA 15232 USA
2010
Source PublicationONCOGENE
Volume29Issue:3Pages:421-431
AbstractInactivation of U19/EAF2 has been shown previously to lead to tumorigenesis in multiple organs; however, the mechanism of U19/EAF2 tumor suppression remains unclear. In this paper, we report that the expression of an anti-angiogenic protein, thrombospondin-1 (TSP-1) is down-regulated in the prostate and liver of U19/EAF2 knockout mouse. The U19/EAF2 knockout liver displayed increased CD31-positive blood vessels, suggesting that the TSP-1 down-regulation can contribute to increased angiogenesis. TSP-1 is reported to be a p53-target gene and p53 is a known binding partner of ELL, which binds to U19/EAF2. Here, we show that U19/EAF2 can co-localize and co-immunoprecipitate with p53 in transfected cells. In a TSP-1 promoter-driven luciferase reporter assay, p53 transfection suppressed the TSP-1 promoter activity and U19/EAF2 co-transfection blocked the p53 suppression of TSP-1 promoter. However, U19/EAF2 transfection alone had little or no effect on the TSP-1 promoter. The above observations together suggest that U19/EAF2 regulates the expression of TSP-1 via blocking p53 repression of the TSP-1 promoter. Oncogene (2010) 29, 421-431; doi:10.1038/onc.2009.326; published online 12 October 2009
KeywordU19/eaf2 Prostate Cancer Tumor Suppressor Tsp-1 P53
Department[Su, F.; Pascal, L. E.; Wang, Z.] Univ Pittsburgh, Sch Med, Inst Canc, Dept Urol, Pittsburgh, PA 15232 USA; [Xiao, W.] Chinese Acad Sci, Inst Hydrobiol, Key Lab Biodivers & Conservat Aquat Organisms, Wuhan, Peoples R China; [Wang, Z.] Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15232 USA
Subject AreaBiochemistry & Molecular Biology ; Oncology ; Cell Biology ; Genetics & Heredity
Funding OrganizationNIH [R01 CA 120386, R37 DK51993]; Prostate Cancer Specialized Program of Research Excellence (SPORE) [P50 CA90386] ; NIH [R01 CA 120386, R37 DK51993]; Prostate Cancer Specialized Program of Research Excellence (SPORE) [P50 CA90386] ; NIH [R01 CA 120386, R37 DK51993]; Prostate Cancer Specialized Program of Research Excellence (SPORE) [P50 CA90386] ; NIH [R01 CA 120386, R37 DK51993]; Prostate Cancer Specialized Program of Research Excellence (SPORE) [P50 CA90386]
Indexed BySCI
WOS IDWOS:000273793200011
Funding OrganizationNIH [R01 CA 120386, R37 DK51993]; Prostate Cancer Specialized Program of Research Excellence (SPORE) [P50 CA90386] ; NIH [R01 CA 120386, R37 DK51993]; Prostate Cancer Specialized Program of Research Excellence (SPORE) [P50 CA90386] ; NIH [R01 CA 120386, R37 DK51993]; Prostate Cancer Specialized Program of Research Excellence (SPORE) [P50 CA90386] ; NIH [R01 CA 120386, R37 DK51993]; Prostate Cancer Specialized Program of Research Excellence (SPORE) [P50 CA90386]
Citation statistics
Cited Times:32[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/13860
Collection水生生物多样性与资源保护研究中心_期刊论文
Corresponding AuthorWang, Z, Univ Pittsburgh, Sch Med, Inst Canc, Dept Urol, 5200 Ctr Ave,Suite G40, Pittsburgh, PA 15232 USA
Recommended Citation
GB/T 7714
Su, F.,Pascal, L. E.,Xiao, W.,et al. Tumor suppressor U19/EAF2 regulates thrombospondin-1 expression via p53[J]. ONCOGENE,2010,29(3):421-431.
APA Su, F.,Pascal, L. E.,Xiao, W.,Wang, Z.,&Wang, Z, Univ Pittsburgh, Sch Med, Inst Canc, Dept Urol, 5200 Ctr Ave,Suite G40, Pittsburgh, PA 15232 USA.(2010).Tumor suppressor U19/EAF2 regulates thrombospondin-1 expression via p53.ONCOGENE,29(3),421-431.
MLA Su, F.,et al."Tumor suppressor U19/EAF2 regulates thrombospondin-1 expression via p53".ONCOGENE 29.3(2010):421-431.
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