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Caveolin-1 regulates dorsoventral patterning through direct interaction with beta-catenin in zebrafish
Mo, Saijun; Wang, Lu; Li, Qing; Li, Jie; Li, Yuanyuan; Thannickal, Victor J.; Cui, Zongbin; Cui, ZB, Chinese Acad Sci, Inst Hydrobiol, 7 S Donghu Rd, Wuhan 430072, Hubei, Peoples R China
2010
Source PublicationDEVELOPMENTAL BIOLOGY
ISSN0012-1606
Volume344Issue:1Pages:210-223
AbstractCaveolin-1 (Cav-1) is the principal component of plasma membrane caveolae that negatively regulates a number of cellular signaling events including canonical Wnt signaling Activation of the Wnt/beta-catenin pathway is essential for dorsal organizer formation and specification in early vertebrate embryos, but it remains not well understood what controls dorsal activity of maternal beta-catenin and how Cav-1 functions in zebrafish embryogenesis Here, we report that Cav-1 is required for proper dorsoventral patterning in zebrafish Both Win and BMP signals act coordinately to negatively control transcriptional expression of cav-1 during embryonic development. Ectopic expression of Cav-1 alpha or -1 beta resulted in formation of typical ventralized embryos, whereas Cav-1 knockdown led to abnormal embryos with expanded expression of dorsal genes Cav-1 overexpression disrupts the nuclear translocation of beta-catenin through the interaction of its scaffolding domain with Cav-1 binding motif of beta-catenin This reciprocal interaction is necessary for the ventralizing activity of Cav-1 We have further demonstrated that human Cav-1 proteins have conserved ventralizing activity in zebrafish embryogenesis. Thus, maternally expressed zebrafish Cav-1 regulates dorsoventral patterning by limiting nuclear translocation of active beta-catenin (C) 2010 Published by Elsevier Inc
KeywordCaveolin-1 Beta-catenin Dorsoventral Patterning Wnt Signaling Zebrafish
Department[Mo, Saijun; Wang, Lu; Li, Qing; Li, Jie; Li, Yuanyuan; Cui, Zongbin] Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China; [Mo, Saijun; Wang, Lu; Li, Qing; Li, Jie; Li, Yuanyuan; Cui, Zongbin] Chinese Acad Sci, Key Lab Biodivers & Conservat Aquat Organism, Wuhan 430072, Hubei, Peoples R China; [Thannickal, Victor J.] Univ Alabama, Div Pulm Allergy & Crit Care Med, Birmingham, AL USA
Subject AreaDevelopmental Biology
Funding OrganizationNational Basic Research Program of China [2009CB941200]; National Natural Science Foundation of China [30671602, 30871442]; National Institute of Health, USA [R01 HL067967] ; National Basic Research Program of China [2009CB941200]; National Natural Science Foundation of China [30671602, 30871442]; National Institute of Health, USA [R01 HL067967] ; National Basic Research Program of China [2009CB941200]; National Natural Science Foundation of China [30671602, 30871442]; National Institute of Health, USA [R01 HL067967] ; National Basic Research Program of China [2009CB941200]; National Natural Science Foundation of China [30671602, 30871442]; National Institute of Health, USA [R01 HL067967]
Indexed BySCI
Language英语
WOS IDWOS:000280426400019
Funding OrganizationNational Basic Research Program of China [2009CB941200]; National Natural Science Foundation of China [30671602, 30871442]; National Institute of Health, USA [R01 HL067967] ; National Basic Research Program of China [2009CB941200]; National Natural Science Foundation of China [30671602, 30871442]; National Institute of Health, USA [R01 HL067967] ; National Basic Research Program of China [2009CB941200]; National Natural Science Foundation of China [30671602, 30871442]; National Institute of Health, USA [R01 HL067967] ; National Basic Research Program of China [2009CB941200]; National Natural Science Foundation of China [30671602, 30871442]; National Institute of Health, USA [R01 HL067967]
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Cited Times:32[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/13745
Collection水生生物分子与细胞生物学研究中心_期刊论文
Corresponding AuthorCui, ZB, Chinese Acad Sci, Inst Hydrobiol, 7 S Donghu Rd, Wuhan 430072, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Mo, Saijun,Wang, Lu,Li, Qing,et al. Caveolin-1 regulates dorsoventral patterning through direct interaction with beta-catenin in zebrafish[J]. DEVELOPMENTAL BIOLOGY,2010,344(1):210-223.
APA Mo, Saijun.,Wang, Lu.,Li, Qing.,Li, Jie.,Li, Yuanyuan.,...&Cui, ZB, Chinese Acad Sci, Inst Hydrobiol, 7 S Donghu Rd, Wuhan 430072, Hubei, Peoples R China.(2010).Caveolin-1 regulates dorsoventral patterning through direct interaction with beta-catenin in zebrafish.DEVELOPMENTAL BIOLOGY,344(1),210-223.
MLA Mo, Saijun,et al."Caveolin-1 regulates dorsoventral patterning through direct interaction with beta-catenin in zebrafish".DEVELOPMENTAL BIOLOGY 344.1(2010):210-223.
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