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学科主题: Pharmacology & Pharmacy; Toxicology
题名: Chronic exposure to environmental levels of tribromophenol impairs zebrafish reproduction
作者: Deng, Jun1, 2; Liu, Chunsheng1; Yu, Liqin1; Zhou, Bingsheng1
通讯作者: Zhou, BS, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
关键词: Tribromophenol ; Endocrine disruption ; Sex hormones ; Steroidogenic genes ; Reproduction ; Zebrafish
刊名: TOXICOLOGY AND APPLIED PHARMACOLOGY
发表日期: 2010-02-15
DOI: 10.1016/j.taap.2009.11.016
卷: 243, 期:1, 页:87-95
收录类别: SCI
文章类型: Article
部门归属: [Deng, Jun; Liu, Chunsheng; Yu, Liqin; Zhou, Bingsheng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; [Deng, Jun] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: Ministry of Science and Technology of China [2006AA06Z420]; National Nature Science Foundation of China [20890113]; State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ10]
类目[WOS]: Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ; Toxicology
摘要: Tribromophenol (2,4,6-TBP) is ubiquitously found in aquatic environments and biota. In this study, we exposed zebrafish embryos (F-0; 2 '''' days post-fertilization, dpf) to environmental concentration (0.3 mu g/L) and a higher concentration (3.0 mu g/L) of TBP and assessed the impact of chronic exposure (120 dpf) on reproduction. TBP exposure did not cause a significant increase in the malformation and reduction in the survival in the F-0-generation fish. After TBP exposure, the plasma testosterone and estradiol levels significantly increased in males and decreased in females. The transcription of steroidogenic genes (3 beta-HSD, 17 beta-HSD, CYP17, CYP19A, CYP19B) was significantly upregulated in the brain and testes in males and downregulated in the brain and ovary in females. TBP exposure significantly downregulated and upregulated the expression of VTG in the liver of female and male fish, respectively. Meanwhile, TBP exposure altered the sex ratio toward a male-dominant state. The F-1-generation larvae exhibited increased malformation, reduced survival, and retarded growth, suggesting that TBP in the aquatic environment has significant adverse effects on fish population. (C) 2009 Elsevier Inc. All rights reserved
英文摘要: Tribromophenol (2,4,6-TBP) is ubiquitously found in aquatic environments and biota. In this study, we exposed zebrafish embryos (F(0); 2 '''' days post-fertilization, dpf) to environmental concentration (0.3 mu g/L) and a higher concentration (3.0 mu g/L) of TBP and assessed the impact of chronic exposure (120 dpf) on reproduction. TBP exposure did not cause a significant increase in the malformation and reduction in the survival in the F(0)-generation fish. After TBP exposure, the plasma testosterone and estradiol levels significantly increased in males and decreased in females. The transcription of steroidogenic genes (3 beta-HSD, 17 beta-HSD, CYP17, CYP19A, CYP19B) was significantly upregulated in the brain and testes in males and downregulated in the brain and ovary in females. TBP exposure significantly downregulated and upregulated the expression of VTG in the liver of female and male fish, respectively. Meanwhile, TBP exposure altered the sex ratio toward a male-dominant state. The F(1)-generation larvae exhibited increased malformation, reduced survival, and retarded growth, suggesting that TBP in the aquatic environment has significant adverse effects on fish population. (C) 2009 Elsevier Inc. All rights reserved
关键词[WOS]: BROMINATED FLAME RETARDANTS ; MINNOW PIMEPHALES-PROMELAS ; MEDAKA ORYZIAS-LATIPES ; LIFE-CYCLE TEST ; DANIO-RERIO ; DEVELOPMENTAL EXPOSURE ; AROMATASE INHIBITOR ; GAS-CHROMATOGRAPHY ; SYNTHETIC ESTROGEN ; GOBIOCYPRIS-RARUS
语种: 英语
WOS记录号: WOS:000274489700011
ISSN号: 0041-008X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/13723
Appears in Collections:水环境工程研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Deng, Jun; Liu, Chunsheng; Yu, Liqin; Zhou, Bingsheng.Chronic exposure to environmental levels of tribromophenol impairs zebrafish reproduction,TOXICOLOGY AND APPLIED PHARMACOLOGY,2010,243(1):87-95
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