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Chronic exposure to environmental levels of tribromophenol impairs zebrafish reproduction
Deng, Jun; Liu, Chunsheng; Yu, Liqin; Zhou, Bingsheng; Zhou, BS, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2010
Source PublicationTOXICOLOGY AND APPLIED PHARMACOLOGY
ISSN0041-008X
Volume243Issue:1Pages:87-95
AbstractTribromophenol (2,4,6-TBP) is ubiquitously found in aquatic environments and biota. In this study, we exposed zebrafish embryos (F-0; 2 '''' days post-fertilization, dpf) to environmental concentration (0.3 mu g/L) and a higher concentration (3.0 mu g/L) of TBP and assessed the impact of chronic exposure (120 dpf) on reproduction. TBP exposure did not cause a significant increase in the malformation and reduction in the survival in the F-0-generation fish. After TBP exposure, the plasma testosterone and estradiol levels significantly increased in males and decreased in females. The transcription of steroidogenic genes (3 beta-HSD, 17 beta-HSD, CYP17, CYP19A, CYP19B) was significantly upregulated in the brain and testes in males and downregulated in the brain and ovary in females. TBP exposure significantly downregulated and upregulated the expression of VTG in the liver of female and male fish, respectively. Meanwhile, TBP exposure altered the sex ratio toward a male-dominant state. The F-1-generation larvae exhibited increased malformation, reduced survival, and retarded growth, suggesting that TBP in the aquatic environment has significant adverse effects on fish population. (C) 2009 Elsevier Inc. All rights reserved
KeywordTribromophenol Endocrine Disruption Sex Hormones Steroidogenic Genes Reproduction Zebrafish
Department[Deng, Jun; Liu, Chunsheng; Yu, Liqin; Zhou, Bingsheng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; [Deng, Jun] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Subject AreaPharmacology & Pharmacy ; Toxicology
Funding OrganizationMinistry of Science and Technology of China [2006AA06Z420]; National Nature Science Foundation of China [20890113]; State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ10] ; Ministry of Science and Technology of China [2006AA06Z420]; National Nature Science Foundation of China [20890113]; State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ10] ; Ministry of Science and Technology of China [2006AA06Z420]; National Nature Science Foundation of China [20890113]; State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ10] ; Ministry of Science and Technology of China [2006AA06Z420]; National Nature Science Foundation of China [20890113]; State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ10]
Indexed BySCI
Language英语
WOS IDWOS:000274489700011
Funding OrganizationMinistry of Science and Technology of China [2006AA06Z420]; National Nature Science Foundation of China [20890113]; State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ10] ; Ministry of Science and Technology of China [2006AA06Z420]; National Nature Science Foundation of China [20890113]; State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ10] ; Ministry of Science and Technology of China [2006AA06Z420]; National Nature Science Foundation of China [20890113]; State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ10] ; Ministry of Science and Technology of China [2006AA06Z420]; National Nature Science Foundation of China [20890113]; State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ10]
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/13723
Collection水环境工程研究中心_期刊论文
Corresponding AuthorZhou, BS, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Deng, Jun,Liu, Chunsheng,Yu, Liqin,et al. Chronic exposure to environmental levels of tribromophenol impairs zebrafish reproduction[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY,2010,243(1):87-95.
APA Deng, Jun,Liu, Chunsheng,Yu, Liqin,Zhou, Bingsheng,&Zhou, BS, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.(2010).Chronic exposure to environmental levels of tribromophenol impairs zebrafish reproduction.TOXICOLOGY AND APPLIED PHARMACOLOGY,243(1),87-95.
MLA Deng, Jun,et al."Chronic exposure to environmental levels of tribromophenol impairs zebrafish reproduction".TOXICOLOGY AND APPLIED PHARMACOLOGY 243.1(2010):87-95.
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