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学科主题: Marine & Freshwater Biology; Toxicology
题名: Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 fluorotelomer alcohol
作者: Liu, Chunsheng1, 2; Deng, Jun1; Yu, Liqin1; Ramesh, Mathan3; Zhou, Bingsheng1
通讯作者: Zhou, BS, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
关键词: Fluorotelomer alcohols ; Fecundity ; Gamatogenesis ; Sex hormone ; Gene transcription ; Reproductive toxicity
刊名: AQUATIC TOXICOLOGY
发表日期: 2010-01-21
DOI: 10.1016/j.aquatox.2009.09.012
卷: 96, 期:1, 页:70-76
收录类别: SCI
文章类型: Article
部门归属: [Liu, Chunsheng; Deng, Jun; Yu, Liqin; Zhou, Bingsheng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; [Liu, Chunsheng] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China; [Ramesh, Mathan] Bharathiar Univ, Dept Zool, Toxicol Unit, Coimbatore 641046, Tamil Nadu, India
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: National Natural Science Foundation of China [20890113, 20877094]; State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ10]
类目[WOS]: Marine & Freshwater Biology ; Toxicology
研究领域[WOS]: Marine & Freshwater Biology ; Toxicology
摘要: The fluorotelomer alcohols (FTOHs) have been detected in the aquatic environment and shown potential estrogenic activity, but the effects on fish reproduction remain unknown. In the present study, 4-month-old zebrafish were exposed to different concentrations of 8:2 FTOH (0, 10, 30, 90, 270 mu g/L) for 4 weeks, and the impact on reproduction was investigated. The plasma testosterone (T) and estradiol (E2) levels were significantly increased in the females, while T and E2 levels were decreased and increased in the males, respectively. The average number of eggs spawned and sperm production were reduced upon exposure to the chemical,which also resulted in thinning of eggshell, and reduced protein content and egg diameter. Histological examination showed promotion of oocyte maturation and retarded spermiation in female and male fish, respectively. The gene transcription of follicle-stimulating hormone beta (FSH beta) and luteinizing hormone beta (LH beta) in the pituitary were up- and down-regulated in female and male fish, respectively. Up-regulation of vitellogenin (VTG1) and zona pellucida protein 2 (ZP2a) gene transcription was observed in the males, indicating estrogenic activity. However, down-regulation of gene transcription of VTG1 and ZP2a was measured in the females, associated with decreased fecundity. In addition, exposure of adult zebrafish to 8:2 FTOH caused reduced hatching rates in the offspring. The results demonstrated that waterborne exposure to 8:2 FTOH caused disruption of sex hormone biosynthesis and impaired reproduction in adult zebrafish, ultimately resulting in decreased hatching rates in the offspring. (C) 2009 Elsevier B.V. All rights reserved.
英文摘要: The fluorotelomer alcohols (FTOHs) have been detected in the aquatic environment and shown potential estrogenic activity, but the effects on fish reproduction remain unknown. In the present study, 4-month-old zebrafish were exposed to different concentrations of 8:2 FTOH (0, 10, 30, 90, 270 mu g/L) for 4 weeks, and the impact on reproduction was investigated. The plasma testosterone (T) and estradiol (E2) levels were significantly increased in the females, while T and E2 levels were decreased and increased in the males, respectively. The average number of eggs spawned and sperm production were reduced upon exposure to the chemical,which also resulted in thinning of eggshell, and reduced protein content and egg diameter. Histological examination showed promotion of oocyte maturation and retarded spermiation in female and male fish, respectively. The gene transcription of follicle-stimulating hormone beta (FSH beta) and luteinizing hormone beta (LH beta) in the pituitary were up- and down-regulated in female and male fish, respectively. Up-regulation of vitellogenin (VTG1) and zona pellucida protein 2 (ZP2a) gene transcription was observed in the males, indicating estrogenic activity. However, down-regulation of gene transcription of VTG1 and ZP2a was measured in the females, associated with decreased fecundity. In addition, exposure of adult zebrafish to 8:2 FTOH caused reduced hatching rates in the offspring. The results demonstrated that waterborne exposure to 8:2 FTOH caused disruption of sex hormone biosynthesis and impaired reproduction in adult zebrafish, ultimately resulting in decreased hatching rates in the offspring. (C) 2009 Elsevier B.V. All rights reserved.
关键词[WOS]: MINNOW PIMEPHALES-PROMELAS ; MEDAKA ORYZIAS-LATIPES ; DANIO-RERIO ; PERFLUORINATED CHEMICALS ; OOCYTE MATURATION ; GAMETE QUALITY ; ESTROGEN ; VITELLOGENIN ; GONADOTROPIN ; EXPRESSION
语种: 英语
WOS记录号: WOS:000274758200007
ISSN号: 0166-445X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/13721
Appears in Collections:水环境工程研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Bharathiar Univ, Dept Zool, Toxicol Unit, Coimbatore 641046, Tamil Nadu, India

Recommended Citation:
Liu, Chunsheng; Deng, Jun; Yu, Liqin; Ramesh, Mathan; Zhou, Bingsheng.Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 fluorotelomer alcohol,AQUATIC TOXICOLOGY,2010,96(1):70-76
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