IHB OpenIR  > 水环境工程研究中心  > 期刊论文
Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 fluorotelomer alcohol
Liu, Chunsheng; Deng, Jun; Yu, Liqin; Ramesh, Mathan; Zhou, Bingsheng; Zhou, BS, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2010
Source PublicationAQUATIC TOXICOLOGY
ISSN0166-445X
Volume96Issue:1Pages:70-76
AbstractThe fluorotelomer alcohols (FTOHs) have been detected in the aquatic environment and shown potential estrogenic activity, but the effects on fish reproduction remain unknown. In the present study, 4-month-old zebrafish were exposed to different concentrations of 8:2 FTOH (0, 10, 30, 90, 270 mu g/L) for 4 weeks, and the impact on reproduction was investigated. The plasma testosterone (T) and estradiol (E2) levels were significantly increased in the females, while T and E2 levels were decreased and increased in the males, respectively. The average number of eggs spawned and sperm production were reduced upon exposure to the chemical,which also resulted in thinning of eggshell, and reduced protein content and egg diameter. Histological examination showed promotion of oocyte maturation and retarded spermiation in female and male fish, respectively. The gene transcription of follicle-stimulating hormone beta (FSH beta) and luteinizing hormone beta (LH beta) in the pituitary were up- and down-regulated in female and male fish, respectively. Up-regulation of vitellogenin (VTG1) and zona pellucida protein 2 (ZP2a) gene transcription was observed in the males, indicating estrogenic activity. However, down-regulation of gene transcription of VTG1 and ZP2a was measured in the females, associated with decreased fecundity. In addition, exposure of adult zebrafish to 8:2 FTOH caused reduced hatching rates in the offspring. The results demonstrated that waterborne exposure to 8:2 FTOH caused disruption of sex hormone biosynthesis and impaired reproduction in adult zebrafish, ultimately resulting in decreased hatching rates in the offspring. (C) 2009 Elsevier B.V. All rights reserved.
KeywordFluorotelomer Alcohols Fecundity Gamatogenesis Sex Hormone Gene Transcription Reproductive Toxicity
Department[Liu, Chunsheng; Deng, Jun; Yu, Liqin; Zhou, Bingsheng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; [Liu, Chunsheng] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China; [Ramesh, Mathan] Bharathiar Univ, Dept Zool, Toxicol Unit, Coimbatore 641046, Tamil Nadu, India
Subject AreaMarine & Freshwater Biology ; Toxicology
Funding OrganizationNational Natural Science Foundation of China [20890113, 20877094]; State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ10] ; National Natural Science Foundation of China [20890113, 20877094]; State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ10] ; National Natural Science Foundation of China [20890113, 20877094]; State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ10] ; National Natural Science Foundation of China [20890113, 20877094]; State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ10]
Indexed BySCI
Language英语
WOS IDWOS:000274758200007
Funding OrganizationNational Natural Science Foundation of China [20890113, 20877094]; State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ10] ; National Natural Science Foundation of China [20890113, 20877094]; State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ10] ; National Natural Science Foundation of China [20890113, 20877094]; State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ10] ; National Natural Science Foundation of China [20890113, 20877094]; State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ10]
Citation statistics
Cited Times:59[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/13721
Collection水环境工程研究中心_期刊论文
Corresponding AuthorZhou, BS, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Liu, Chunsheng,Deng, Jun,Yu, Liqin,et al. Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 fluorotelomer alcohol[J]. AQUATIC TOXICOLOGY,2010,96(1):70-76.
APA Liu, Chunsheng,Deng, Jun,Yu, Liqin,Ramesh, Mathan,Zhou, Bingsheng,&Zhou, BS, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.(2010).Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 fluorotelomer alcohol.AQUATIC TOXICOLOGY,96(1),70-76.
MLA Liu, Chunsheng,et al."Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 fluorotelomer alcohol".AQUATIC TOXICOLOGY 96.1(2010):70-76.
Files in This Item:
File Name/Size DocType Version Access License
Endocrine disruption(429KB) 开放获取--View Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Liu, Chunsheng]'s Articles
[Deng, Jun]'s Articles
[Yu, Liqin]'s Articles
Baidu academic
Similar articles in Baidu academic
[Liu, Chunsheng]'s Articles
[Deng, Jun]'s Articles
[Yu, Liqin]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Liu, Chunsheng]'s Articles
[Deng, Jun]'s Articles
[Yu, Liqin]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Endocrine disruption and reproductive impairment in zebrafish by exposure to 8-2 fluorotelomer alcohol.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.