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学科主题: Pharmacology & Pharmacy; Toxicology
题名: Simulated microgravity alters growth and microcystin production in Microcystis aeruginosa (cyanophyta)
作者: Xiao, Yuan1, 2; Liu, Yongding1; Wang, Gaohong1; Hao, Zongjie1, 2; An, Yanjun1, 2
通讯作者: Liu, YD, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Fresh Water Ecol & Biotechnol, 7 S Donghu Rd, Wuhan 430072, Hubei, Peoples R China
关键词: Simulated microgravity ; Microcystis aeruginosa ; Microcystin ; Secondary metabolism
刊名: TOXICON
发表日期: 2010-08-01
DOI: 10.1016/j.toxicon.2010.01.026
卷: 56, 期:1, 页:1-7
收录类别: SCI
文章类型: Article
部门归属: [Xiao, Yuan; Liu, Yongding; Wang, Gaohong; Hao, Zongjie; An, Yanjun] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Fresh Water Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China; [Xiao, Yuan; Hao, Zongjie; An, Yanjun] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: Chinese Manned Space Flight Project ; Natural Science Foundation of China [30970688]
类目[WOS]: Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ; Toxicology
摘要: Recent researches indicated that microgravity can increase pathogenic bacteria virulence. We presumed that microgravity might affect the toxin production of toxic cyanobacteria too. Microcystis aeruginosa PCC7806 was chosen as the model organism to investigate the effects of simulated microgravity (SMG) on the growth and toxin production of toxic cyanobacteria. SMG could inhibit the growth of M. aeruginosa, which resulted in decreased cell number and lower specific growth rate after 20-day treatment. M. aeruginosa sensed the reduced gravity very quickly and immediately up-regulated its microcystin (MC) synthesis and exudation in 2 days. Subsequently, the intracellular MC content fell back since the 8(th) day and was stable around the initial level in the following days, suggesting a quick adaptation to the reduced gravity. SMG had negative effects on the photochemical system and the absorption of phosphorus in most time. However, the photosynthetic pigment concentrations and nitrogen absorption used to be transitorily stimulated upwards by SMG. It was assumed that SMG inhibited cell growth by interfering its photosynthesis and phosphorus uptake, while the enhanced MC production was related with pigment and nitrogen metabolisms. This study reveals that SMG is a novel environmental signal which inhibits growth and enhances MC production of M. aeruginosa. (C) 2010 Elsevier Ltd. All rights reserved.
英文摘要: Recent researches indicated that microgravity can increase pathogenic bacteria virulence. We presumed that microgravity might affect the toxin production of toxic cyanobacteria too. Microcystis aeruginosa PCC7806 was chosen as the model organism to investigate the effects of simulated microgravity (SMG) on the growth and toxin production of toxic cyanobacteria. SMG could inhibit the growth of M. aeruginosa, which resulted in decreased cell number and lower specific growth rate after 20-day treatment. M. aeruginosa sensed the reduced gravity very quickly and immediately up-regulated its microcystin (MC) synthesis and exudation in 2 days. Subsequently, the intracellular MC content fell back since the 8(th) day and was stable around the initial level in the following days, suggesting a quick adaptation to the reduced gravity. SMG had negative effects on the photochemical system and the absorption of phosphorus in most time. However, the photosynthetic pigment concentrations and nitrogen absorption used to be transitorily stimulated upwards by SMG. It was assumed that SMG inhibited cell growth by interfering its photosynthesis and phosphorus uptake, while the enhanced MC production was related with pigment and nitrogen metabolisms. This study reveals that SMG is a novel environmental signal which inhibits growth and enhances MC production of M. aeruginosa. (C) 2010 Elsevier Ltd. All rights reserved.
关键词[WOS]: SHEAR MODELED MICROGRAVITY ; BACTERIAL GENE-EXPRESSION ; SPACE-FLIGHT ; MICROALGAE ; VIRULENCE ; NITROGEN ; PCC7806
语种: 英语
WOS记录号: WOS:000278205500001
ISSN号: 0041-0101
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/13703
Appears in Collections:水环境工程研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Fresh Water Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Xiao, Yuan; Liu, Yongding; Wang, Gaohong; Hao, Zongjie; An, Yanjun.Simulated microgravity alters growth and microcystin production in Microcystis aeruginosa (cyanophyta),TOXICON,2010,56(1):1-7
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