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Distinct Genetic Diversity of Oncomelania hupensis, Intermediate Host of Schistosoma japonicum in Mainland China as Revealed by ITS Sequences
Zhao, Qin Ping; Sen Jiang, Ming; Littlewood, D. Timothy J.; Nie, Pin; Zhao, QP, Wuhan Univ, Dept Parasitol, Sch Basic Med Sci, Wuhan 430072, Hubei Province, Peoples R China
2010
Source PublicationPLOS NEGLECTED TROPICAL DISEASES
ISSN1935-2727
Volume4Issue:3Pages:-
AbstractBackground: Oncomelania hupensis is the unique intermediate host of Schistosoma japonicum, which causes schistosomiasis endemic in the Far East, and especially in mainland China. O. hupensis largely determines the parasite's geographical range. How O. hupensis's genetic diversity is distributed geographically in mainland China has never been well examined with DNA sequence data. Methodology/Principal Findings: In this study we investigate the genetic variation among O. hupensis from different geographical origins using the combined complete internal transcribed spacer 1 (ITS1) and ITS2 regions of nuclear ribosomal DNA. 165 O. hupensis isolates were obtained in 29 localities from 7 provinces across mainland China: lake/marshland and hill regions in Anhui, Hubei, Hunan, Jiangxi and Jiangsu provinces, located along the middle and lower reaches of Yangtze River, and mountainous regions in Sichuan and Yunnan provinces. Phylogenetic and haplotype network analyses showed distinct genetic diversity and no shared haplotypes between populations from lake/marshland regions of the middle and lower reaches of the Yangtze River and populations from mountainous regions of Sichuan and Yunnan provinces. The genetic distance between these two groups is up to 0.81 based on Fst, and branch time was estimated as 26 Ma. As revealed in the phylogenetic tree, snails from Sichuan and Yunnan provinces were also clustered separately. Geographical separation appears to be an important factor accounting for the diversification of the two groups of O. hupensis in mainland China, and probably for the separate clades between snails from Sichuan and Yunnan provinces. In lake/marshland and hill regions along the middle and lower reaches of the Yangtze River, three clades were identified in the phylogenetic tree, but without any obvious clustering of snails from different provinces. Conclusions: O. hupensis in mainland China may have considerable genetic diversity, and a more complex population structure than expected. It will be of significant importance to consider the genetic diversity of O. hupensis when assessing co-evolutionary interactions with S. japonicum.
KeywordFragment Length Polymorphisms Molecular Phylogeny Population-structure Dna Polymorphism Gastropoda Pomatiopsidae Rissooidea Snail Biogeography Coevolution
Department[Zhao, Qin Ping; Sen Jiang, Ming] Wuhan Univ, Dept Parasitol, Sch Basic Med Sci, Wuhan 430072, Hubei Province, Peoples R China; [Zhao, Qin Ping; Nie, Pin] Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Inst Hydrobiol, Wuhan, Hubei Province, Peoples R China; [Littlewood, D. Timothy J.] Nat Hist Museum, Dept Zool, London SW7 5BD, England
Subject AreaInfectious Diseases ; Parasitology ; Tropical Medicine
Funding OrganizationChinese Academy of Sciences [KSCX2-YW-N-055, KSCX2-YW-2-0808]; National Natural Science Foundation of China [30770353] ; Chinese Academy of Sciences [KSCX2-YW-N-055, KSCX2-YW-2-0808]; National Natural Science Foundation of China [30770353] ; Chinese Academy of Sciences [KSCX2-YW-N-055, KSCX2-YW-2-0808]; National Natural Science Foundation of China [30770353] ; Chinese Academy of Sciences [KSCX2-YW-N-055, KSCX2-YW-2-0808]; National Natural Science Foundation of China [30770353]
Indexed BySCI
Language英语
WOS IDWOS:000276312200028
Funding OrganizationChinese Academy of Sciences [KSCX2-YW-N-055, KSCX2-YW-2-0808]; National Natural Science Foundation of China [30770353] ; Chinese Academy of Sciences [KSCX2-YW-N-055, KSCX2-YW-2-0808]; National Natural Science Foundation of China [30770353] ; Chinese Academy of Sciences [KSCX2-YW-N-055, KSCX2-YW-2-0808]; National Natural Science Foundation of China [30770353] ; Chinese Academy of Sciences [KSCX2-YW-N-055, KSCX2-YW-2-0808]; National Natural Science Foundation of China [30770353]
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/13639
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorZhao, QP, Wuhan Univ, Dept Parasitol, Sch Basic Med Sci, Wuhan 430072, Hubei Province, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Qin Ping,Sen Jiang, Ming,Littlewood, D. Timothy J.,et al. Distinct Genetic Diversity of Oncomelania hupensis, Intermediate Host of Schistosoma japonicum in Mainland China as Revealed by ITS Sequences[J]. PLOS NEGLECTED TROPICAL DISEASES,2010,4(3):-.
APA Zhao, Qin Ping,Sen Jiang, Ming,Littlewood, D. Timothy J.,Nie, Pin,&Zhao, QP, Wuhan Univ, Dept Parasitol, Sch Basic Med Sci, Wuhan 430072, Hubei Province, Peoples R China.(2010).Distinct Genetic Diversity of Oncomelania hupensis, Intermediate Host of Schistosoma japonicum in Mainland China as Revealed by ITS Sequences.PLOS NEGLECTED TROPICAL DISEASES,4(3),-.
MLA Zhao, Qin Ping,et al."Distinct Genetic Diversity of Oncomelania hupensis, Intermediate Host of Schistosoma japonicum in Mainland China as Revealed by ITS Sequences".PLOS NEGLECTED TROPICAL DISEASES 4.3(2010):-.
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