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The gene and virus-induced expression of IRF-5 in grass carp Ctenopharyngodon idella
Xu, Qiao Q.; Chang, Ming X.; Xiao, Fan S.; Huang, Bei; Nie, Pin; Nie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei Province, Peoples R China
2010
Source PublicationVETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
ISSN0165-2427
Volume134Issue:40241Pages:269-278
AbstractThe interferon regulatory factor 5 (IRF-5) is known to be involved in the innate immune response and in the regulation of DNA damage-induced apoptosis. In the present study, the cDNA and genomic sequences of IRF-5 were identified in grass carp (Ctenophonyngodon idella). The cDNA of grass carp IRF-5 (gcIRF-5) contains an open reading frame (ORF) of 1560 nucleotides, encoding a putative 519 amino acid protein, which showed 34.5-83.9% identity to IRF-5 homologues from mammals, amphibian, avian and fish, and 96.2% and 95.0% identity to zebrafish IRF-5 in the DNA-binding domain (DBD) and IRF association domain (IAD), respectively. The genomic DNA sequence of gcIRF-5 contains 6075 bp consisting of 9 exons and 8 introns. The expression of gcIRF-5 was observed in all organs examined. The analysis of real-time quantitative RT-PCR revealed that grass carp reovirus (GCRV) induced the expression of gcIRF-5 in spleen and head kidney. (C) 2009 Elsevier B.V. All rights reserved.
KeywordIrf-5 Genome Expression Gchv Grass Carp Ctenopharyngodon Idella
Department[Xu, Qiao Q.; Chang, Ming X.; Xiao, Fan S.; Huang, Bei; Nie, Pin] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei Province, Peoples R China; [Xu, Qiao Q.] Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Hubei Province, Peoples R China; [Xu, Qiao Q.] Yangtze Univ, Sch Anim Sci, Jinzhou 434025, Hubei Province, Peoples R China
Subject AreaImmunology ; Veterinary Sciences
Indexed BySCI
Language英语
WOS IDWOS:000276518700015
Citation statistics
Cited Times:32[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/13635
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorNie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei Province, Peoples R China
Recommended Citation
GB/T 7714
Xu, Qiao Q.,Chang, Ming X.,Xiao, Fan S.,et al. The gene and virus-induced expression of IRF-5 in grass carp Ctenopharyngodon idella[J]. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,2010,134(40241):269-278.
APA Xu, Qiao Q.,Chang, Ming X.,Xiao, Fan S.,Huang, Bei,Nie, Pin,&Nie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei Province, Peoples R China.(2010).The gene and virus-induced expression of IRF-5 in grass carp Ctenopharyngodon idella.VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,134(40241),269-278.
MLA Xu, Qiao Q.,et al."The gene and virus-induced expression of IRF-5 in grass carp Ctenopharyngodon idella".VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 134.40241(2010):269-278.
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