IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Intron-Containing Type I and Type III IFN Coexist in Amphibians: Refuting the Concept That a Retroposition Event Gave Rise to Type I IFNs
Qi, Zhitao; Nie, Pin; Secombes, Chris J.; Zou, Jun; Nie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
2010
Source PublicationJOURNAL OF IMMUNOLOGY
Volume184Issue:9Pages:5038-5046
AbstractType I and III IFNs are structurally related cytokines with similar antiviral functions. They have different genomic organizations and bind to distinct receptor complexes. It has been vigorously debated whether the recently identified intron containing IFN genes in fish and amphibians belong to the type I or HI IFN family or diverged from a common ancestral gene, that subsequently gave rise to both types. In this report, we have identified intron containing type III IFN genes that are tandemly linked in the Xenopus tropicalis genome and hence demonstrate for the first time that intron containing type I and III genes diverged relatively early in vertebrate evolution, and at least by the appearance of early tetrapods, a transition period when vertebrates migrated from an aquatic environment to land. Our data also suggest that the intronless type I IFN genes seen in reptiles, birds, and mammals have originated from a type I IFN transcript via a retroposition event that led to the disappearance of intron-containing type I IFN genes in modern vertebrates. In vivo and in vitro studies in this paper show that the Xenopus type III IFNs and their cognate receptor are ubiquitously expressed in tissues and primary splenocytes and can be upregulated by stimulation with synthetic double-stranded RNA, suggesting they are involved in antiviral defense in amphibians. The Journal of Immunology, 2010, 184: 5038-5046.
KeywordInterferon Genes Receptor Identification Zebrafish Vertebrates Family Fish Expression Cytokines System
Department[Qi, Zhitao; Nie, Pin] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China; [Qi, Zhitao] Yancheng Inst Technol, Chem & Biol Engn Coll, Jiangsu, Peoples R China; [Secombes, Chris J.; Zou, Jun] Univ Aberdeen, Scottish Fish Immunol Res Ctr, Inst Biol & Environm Sci, Aberdeen, Scotland
Subject AreaImmunology
Funding OrganizationNational Natural Science Foundation of China ; Government of Guangdong Province [U0631010]; National Basic Research Program of China (973 Program) [2009CB118703]; Royal Society of Edinburgh ; National Natural Science Foundation of China ; Government of Guangdong Province [U0631010]; National Basic Research Program of China (973 Program) [2009CB118703]; Royal Society of Edinburgh ; National Natural Science Foundation of China ; Government of Guangdong Province [U0631010]; National Basic Research Program of China (973 Program) [2009CB118703]; Royal Society of Edinburgh ; National Natural Science Foundation of China ; Government of Guangdong Province [U0631010]; National Basic Research Program of China (973 Program) [2009CB118703]; Royal Society of Edinburgh
Indexed BySCI
WOS IDWOS:000277093000056
Funding OrganizationNational Natural Science Foundation of China ; Government of Guangdong Province [U0631010]; National Basic Research Program of China (973 Program) [2009CB118703]; Royal Society of Edinburgh ; National Natural Science Foundation of China ; Government of Guangdong Province [U0631010]; National Basic Research Program of China (973 Program) [2009CB118703]; Royal Society of Edinburgh ; National Natural Science Foundation of China ; Government of Guangdong Province [U0631010]; National Basic Research Program of China (973 Program) [2009CB118703]; Royal Society of Edinburgh ; National Natural Science Foundation of China ; Government of Guangdong Province [U0631010]; National Basic Research Program of China (973 Program) [2009CB118703]; Royal Society of Edinburgh
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Cited Times:58[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/13629
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorNie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Qi, Zhitao,Nie, Pin,Secombes, Chris J.,et al. Intron-Containing Type I and Type III IFN Coexist in Amphibians: Refuting the Concept That a Retroposition Event Gave Rise to Type I IFNs[J]. JOURNAL OF IMMUNOLOGY,2010,184(9):5038-5046.
APA Qi, Zhitao,Nie, Pin,Secombes, Chris J.,Zou, Jun,&Nie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China.(2010).Intron-Containing Type I and Type III IFN Coexist in Amphibians: Refuting the Concept That a Retroposition Event Gave Rise to Type I IFNs.JOURNAL OF IMMUNOLOGY,184(9),5038-5046.
MLA Qi, Zhitao,et al."Intron-Containing Type I and Type III IFN Coexist in Amphibians: Refuting the Concept That a Retroposition Event Gave Rise to Type I IFNs".JOURNAL OF IMMUNOLOGY 184.9(2010):5038-5046.
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