IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
In vitro antibacterial effect of berberine hydrochloride and enrofloxacin to fish pathogenic bacteria
Zhang, Defeng; Li, Aihua; Xie, Jun; Ji, Cheng; Li, AH, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2010
Source PublicationAQUACULTURE RESEARCH
ISSN1355-557X
Volume41Issue:7Pages:1095-1100
AbstractBerberine the main antibacterial substance in the rhizome of Coptis chinensis Franch, is used as an antimicrobial agent for a long time. This study was carried out to investigate the potential of berberine alone or in combination with enrofloxacin against six common fish pathogens for use in fish disease management in aquaculture. The minimum inhibitory concentrations (MICs) of berberine hydrochloride against Aeromonas hydrophila, Pseudomonas fluorescens, Vibrio vulnificus, Edwardsiella ictaluri, Escherichia coli and Streptococcus agalactiae were determined and to be > 500, > 500, > 500, 300, 400 and 100 mu g mL-1 respectively. The minimal bactericidal concentrations (MBCs) of berberine hydrochloride to E. coli, E. ictaluri and S. agalactiae were 300-500 mu g mL-1. In combination with enrofloxacin, the MICs and MBCs of berberine hydrochloride significantly decreased against E. coli and E. ictaluri but not against Streptococcus dysgalactiae. These results demonstrated that the berberine hydrochloride enhanced the bactericidal effect of enrofloxacin and vice versa. The synergistic bactericidal effect of berberine hydrochloride and enrofloxacin suggest its potential use in fish disease management in aquaculture. This is the first study on the inhibitory effect of berberine hydrochloride against fish pathogenic bacteria.
KeywordBerberine Hydrochloride Enrofloxacin Fish Pathogenic Bacteria Synergistic Effect
Department[Zhang, Defeng; Li, Aihua; Ji, Cheng] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; [Zhang, Defeng; Ji, Cheng] Chinese Acad Sci, Postgrad Sch, Beijing, Peoples R China; [Xie, Jun] Chinese Acad Fishery Sci, Minist Agr, Freshwater Fisheries Res Ctr, Wuxi, Peoples R China
Subject AreaFisheries
Funding OrganizationNational Science and Technology Pillar Programs [2006BAD03B04, 2006BAK02A22]; National Science Foundation of China [30670112] ; National Science and Technology Pillar Programs [2006BAD03B04, 2006BAK02A22]; National Science Foundation of China [30670112] ; National Science and Technology Pillar Programs [2006BAD03B04, 2006BAK02A22]; National Science Foundation of China [30670112] ; National Science and Technology Pillar Programs [2006BAD03B04, 2006BAK02A22]; National Science Foundation of China [30670112]
Indexed BySCI
Language英语
WOS IDWOS:000278643100017
Funding OrganizationNational Science and Technology Pillar Programs [2006BAD03B04, 2006BAK02A22]; National Science Foundation of China [30670112] ; National Science and Technology Pillar Programs [2006BAD03B04, 2006BAK02A22]; National Science Foundation of China [30670112] ; National Science and Technology Pillar Programs [2006BAD03B04, 2006BAK02A22]; National Science Foundation of China [30670112] ; National Science and Technology Pillar Programs [2006BAD03B04, 2006BAK02A22]; National Science Foundation of China [30670112]
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Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/13609
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorLi, AH, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Defeng,Li, Aihua,Xie, Jun,et al. In vitro antibacterial effect of berberine hydrochloride and enrofloxacin to fish pathogenic bacteria[J]. AQUACULTURE RESEARCH,2010,41(7):1095-1100.
APA Zhang, Defeng,Li, Aihua,Xie, Jun,Ji, Cheng,&Li, AH, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.(2010).In vitro antibacterial effect of berberine hydrochloride and enrofloxacin to fish pathogenic bacteria.AQUACULTURE RESEARCH,41(7),1095-1100.
MLA Zhang, Defeng,et al."In vitro antibacterial effect of berberine hydrochloride and enrofloxacin to fish pathogenic bacteria".AQUACULTURE RESEARCH 41.7(2010):1095-1100.
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