IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Global characterization of interferon regulatory factor (IRF) genes in vertebrates: Glimpse of the diversification in evolution
Huang, Bei; Qi, Zhi T.; Xu, Zhen; Nie, Pin; Nie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei Province, Peoples R China
2010
Source PublicationBMC IMMUNOLOGY
ISSN1471-2172
Volume11Pages:-
AbstractBackground: Interferon regulatory factors (IRFs), which can be identified based on a unique helix-turn-helix DNA-binding domain (DBD) are a large family of transcription factors involved in host immune response, haemotopoietic differentiation and immunomodulation. Despite the identification of ten IRF family members in mammals, and some recent effort to identify these members in fish, relatively little is known in the composition of these members in other classes of vertebrates, and the evolution and probably the origin of the IRF family have not been investigated in vertebrates. Results: Genome data mining has been performed to identify any possible IRF family members in human, mouse, dog, chicken, anole lizard, frog, and some teleost fish, mainly zebrafish and stickleback, and also in non-vertebrate deuterostomes including the hemichordate, cephalochordate, urochordate and echinoderm. In vertebrates, all ten IRF family members, i.e. IRF-1 to IRF-10 were identified, with two genes of IRF-4 and IRF-6 identified in fish and frog, respectively, except that in zebrafish exist three IRF-4 genes. Surprisingly, an additional member in the IRF family, IRF-11 was found in teleost fish. A range of two to ten IRF-like genes were detected in the non-vertebrate deuterostomes, and they had little similarity to those IRF family members in vertebrates as revealed in genomic structure and in phylogenetic analysis. However, the ten IRF family members, IRF-1 to IRF-10 showed certain degrees of conservation in terms of genomic structure and gene synteny. In particular, IRF-1, IRF-2, IRF-6, IRF-8 are quite conserved in their genomic structure in all vertebrates, and to a less degree, some IRF family members, such as IRF-5 and IRF-9 are comparable in the structure. Synteny analysis revealed that the gene loci for the ten IRF family members in vertebrates were also quite conservative, but in zebrafish conserved genes were distributed in a much longer distance in chromosomes. Furthermore, all ten different members are clustered in respectively different clades; but the IRF-11 was clustered with one in sea urchin. Conclusions: In vertebrates, the ten well-characterized IRF family members shared a relatively high degree of similarity in genomic structure and syntenic gene arrangement, implying that they might have been evolved in a similar pattern and with similar selective pressure in different classes of vertebrates. Genome and/or gene duplication, and probably gene shuffling or gene loss might have occurred during the evolution of these IRF family members, but arrangement of chromosome or its segment might have taken place in zebrafish. However, the ten IRF family members in vertebrates and those IRF-like genes in non-vertebrate deuterostomes were quite different in those analyzed characters, as they might have undergone different patterns of evolution.
KeywordFish Siniperca-chuatsi Genome Evolution Transcription Factors Molecular-cloning Host-defense Zebrafish Family Differentiation Mechanism Chordate
Department[Huang, Bei; Qi, Zhi T.; Xu, Zhen; Nie, Pin] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei Province, Peoples R China; [Huang, Bei] Chinese Acad Sci, Grad Sch, Beijing 10049, Peoples R China
Subject AreaImmunology
Funding OrganizationNational Basic Research Program of China (973 Program) [2009CB118703] ; National Basic Research Program of China (973 Program) [2009CB118703] ; National Basic Research Program of China (973 Program) [2009CB118703] ; National Basic Research Program of China (973 Program) [2009CB118703]
Indexed BySCI
Language英语
WOS IDWOS:000279893200001
Funding OrganizationNational Basic Research Program of China (973 Program) [2009CB118703] ; National Basic Research Program of China (973 Program) [2009CB118703] ; National Basic Research Program of China (973 Program) [2009CB118703] ; National Basic Research Program of China (973 Program) [2009CB118703]
Citation statistics
Cited Times:111[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/13605
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorNie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei Province, Peoples R China
Recommended Citation
GB/T 7714
Huang, Bei,Qi, Zhi T.,Xu, Zhen,et al. Global characterization of interferon regulatory factor (IRF) genes in vertebrates: Glimpse of the diversification in evolution[J]. BMC IMMUNOLOGY,2010,11:-.
APA Huang, Bei,Qi, Zhi T.,Xu, Zhen,Nie, Pin,&Nie, P, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei Province, Peoples R China.(2010).Global characterization of interferon regulatory factor (IRF) genes in vertebrates: Glimpse of the diversification in evolution.BMC IMMUNOLOGY,11,-.
MLA Huang, Bei,et al."Global characterization of interferon regulatory factor (IRF) genes in vertebrates: Glimpse of the diversification in evolution".BMC IMMUNOLOGY 11(2010):-.
Files in This Item:
File Name/Size DocType Version Access License
Global characterizat(5672KB) 开放获取--View Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Huang, Bei]'s Articles
[Qi, Zhi T.]'s Articles
[Xu, Zhen]'s Articles
Baidu academic
Similar articles in Baidu academic
[Huang, Bei]'s Articles
[Qi, Zhi T.]'s Articles
[Xu, Zhen]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Huang, Bei]'s Articles
[Qi, Zhi T.]'s Articles
[Xu, Zhen]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Global characterization of interferon regulatory factor (IRF) genes in vertebrates-Glimpse of the diversification in evolution.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.