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Identification of suppressor of cytokine signalling (SOCS) 6, 7, 9 and CISH in rainbow trout Oncorhynchus mykiss and analysis of their expression in relation to other known trout SOCS
Wang, Tiehui; Gao, Qian; Nie, Pin; Secombes, Christopher J.; Secombes, CJ, Univ Aberdeen, Scottish Fish Immunol Res Ctr, Sch Biol Sci, Aberdeen AB24 2TZ, Scotland
2010
Source PublicationFISH & SHELLFISH IMMUNOLOGY
ISSN1050-4648
Volume29Issue:4Pages:656-667
AbstractFour new members of the SOCS family of molecules in rainbow trout (Oncorhynchus mykiss), CISH and SOCS6, 7 and 9, are described for the first time in this species. The genes had a wide tissue distribution in trout, and were detected in gills, skin, muscle, liver, spleen, head kidney, intestine and brain, with brain having the highest expression levels. Stimulation of a rainbow trout leucocyte cell line, RTS-11, (mononuclear/macrophage-like cells) with LPS or Poly 1:C had no effect on the expression of these genes, although in both cases the previously identified SOCS1-3 genes were up-regulated. Similarly, stimulation of RTS-11 or RTG-2 (fibroblasts) cells with the trout recombinant cytokines IFN-gamma or IL-1 beta had no effect on CISH or SOCS6, 7 and 9 expression. However, PMA stimulation did impact on SOCS6 and SOCS9 expression, and LPS stimulation of primary cultures or bacterial infection (Yersinia ruckeri) increased significantly CISH expression (as well as SOCS1 and SOCS2 or SOCS3 respectively). It is apparent that the type II SOCS genes (CISH, SOCS1-3) are particularly relevant to immune regulation in fish, although the intriguing expansion of the SOCS4/5 subgroup in fish requires further investigation as to their role and functional divergence. (C) 2010 Elsevier Ltd. All rights reserved.
KeywordRainbow Trout Socs Family Expression Modulation Bacterial Infection
Department[Wang, Tiehui; Gao, Qian; Secombes, Christopher J.] Univ Aberdeen, Scottish Fish Immunol Res Ctr, Sch Biol Sci, Aberdeen AB24 2TZ, Scotland; [Gao, Qian; Nie, Pin] Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China
Subject AreaFisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
Funding OrganizationEC [513692, Q5RS-2001-002211]; Royal Society ; EC [513692, Q5RS-2001-002211]; Royal Society ; EC [513692, Q5RS-2001-002211]; Royal Society ; EC [513692, Q5RS-2001-002211]; Royal Society
Indexed BySCI
Language英语
WOS IDWOS:000281500500015
Funding OrganizationEC [513692, Q5RS-2001-002211]; Royal Society ; EC [513692, Q5RS-2001-002211]; Royal Society ; EC [513692, Q5RS-2001-002211]; Royal Society ; EC [513692, Q5RS-2001-002211]; Royal Society
Citation statistics
Cited Times:29[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/13593
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorSecombes, CJ, Univ Aberdeen, Scottish Fish Immunol Res Ctr, Sch Biol Sci, Aberdeen AB24 2TZ, Scotland
Recommended Citation
GB/T 7714
Wang, Tiehui,Gao, Qian,Nie, Pin,et al. Identification of suppressor of cytokine signalling (SOCS) 6, 7, 9 and CISH in rainbow trout Oncorhynchus mykiss and analysis of their expression in relation to other known trout SOCS[J]. FISH & SHELLFISH IMMUNOLOGY,2010,29(4):656-667.
APA Wang, Tiehui,Gao, Qian,Nie, Pin,Secombes, Christopher J.,&Secombes, CJ, Univ Aberdeen, Scottish Fish Immunol Res Ctr, Sch Biol Sci, Aberdeen AB24 2TZ, Scotland.(2010).Identification of suppressor of cytokine signalling (SOCS) 6, 7, 9 and CISH in rainbow trout Oncorhynchus mykiss and analysis of their expression in relation to other known trout SOCS.FISH & SHELLFISH IMMUNOLOGY,29(4),656-667.
MLA Wang, Tiehui,et al."Identification of suppressor of cytokine signalling (SOCS) 6, 7, 9 and CISH in rainbow trout Oncorhynchus mykiss and analysis of their expression in relation to other known trout SOCS".FISH & SHELLFISH IMMUNOLOGY 29.4(2010):656-667.
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