中国科学院水生生物研究所机构知识库
Advanced  
IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
学科主题: Developmental Biology
题名: Mtmr8 is essential for vasculature development in zebrafish embryos
作者: Mei, Jie1; Liu, Sha1; Li, Zhi1; Gui, Jian-Fang1
通讯作者: Gui, JF, Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Ctr Dev Biol, Inst Hydrobiol,Grad Sch, Wuhan 430072, Peoples R China
关键词: ENDOTHELIAL-GROWTH-FACTOR ; PROTEIN-KINASE-A ; GENE-EXPRESSION ; SONIC-HEDGEHOG ; CELL SURVIVAL ; ANGIOGENESIS ; DIFFERENTIATION ; VASCULOGENESIS ; PATHWAY ; MUSCLE
刊名: BMC DEVELOPMENTAL BIOLOGY
发表日期: 2010-09-05
DOI: 10.1186/1471-213X-10-96
卷: 10, 页:-
收录类别: SCI
文章类型: Article
部门归属: [Mei, Jie; Liu, Sha; Li, Zhi; Gui, Jian-Fang] Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Ctr Dev Biol, Inst Hydrobiol,Grad Sch, Wuhan 430072, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: National Major Basic Research Program [2010CB126300]; Chinese Academy of Sciences [KSCX2-YW-N-020, 075A01-1-301, 085A02-1-301]; State Key Laboratory of Freshwater Ecology and Biotechnology [2008FBZ15]; IHB
类目[WOS]: Developmental Biology
研究领域[WOS]: Developmental Biology
摘要: Background: Embryonic morphogenesis of vascular and muscular systems is tightly coordinated, and a functional cooperation of Mtmr8 with PI3K in actin filament modeling and muscle development has been revealed in zebrafish. Here, we attempt to explore the function of Mtmr8 in vasculature development parallel to its function in muscle development. Results: During early stage of somitogenesis, mtmr8 expression was detected in both somitic mesodem and ventral mesoderm. Knockdown of mtmr8 by morpholino impairs arterial endothelial marker expression, and results in endothelial cell reduction and vasculogenesis defects, such as retardation in intersegmental vessel development and interruption of trunk dorsal aorta. Moreover, mtmr8 morphants show loss of arterial endothelial cell identity in dorsal aorta, which is effectively rescued by low concentration of PI3K inhibitor, and by over-expression of dnPKA mRNA or vegf mRNA. Interestingly, mtmr8 expression is up-regulated when zebrafish embryos are treated with specific inhibitor of Hedgehog pathway that abolishes arterial marker expression. Conclusion: These data indicate that Mtmr8 is essential for vasculature development in zebrafish embryos, and may play a role in arterial specification through repressing PI3K activity. It is suggested that Mtmr8 should represent a novel element of the Hedgehog/PI3K/VEGF signaling cascade that controls arterial specification.
英文摘要: Background: Embryonic morphogenesis of vascular and muscular systems is tightly coordinated, and a functional cooperation of Mtmr8 with PI3K in actin filament modeling and muscle development has been revealed in zebrafish. Here, we attempt to explore the function of Mtmr8 in vasculature development parallel to its function in muscle development.
关键词[WOS]: ENDOTHELIAL-GROWTH-FACTOR ; PROTEIN-KINASE-A ; GENE-EXPRESSION ; SONIC-HEDGEHOG ; CELL SURVIVAL ; ANGIOGENESIS ; DIFFERENTIATION ; VASCULOGENESIS ; PATHWAY ; MUSCLE
语种: 英语
WOS记录号: WOS:000282741500001
ISSN号: 1471-213X
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/13577
Appears in Collections:鱼类生物学及渔业生物技术研究中心_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Mtmr8 is essential for vasculature development in zebrafish embryos.pdf(2651KB)----开放获取--View Download

作者单位: 1.Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Ctr Dev Biol, Inst Hydrobiol,Grad Sch, Wuhan 430072, Peoples R China

Recommended Citation:
Mei, Jie; Liu, Sha; Li, Zhi; Gui, Jian-Fang.Mtmr8 is essential for vasculature development in zebrafish embryos,BMC DEVELOPMENTAL BIOLOGY,2010,10():-
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Mei, Jie]'s Articles
[Liu, Sha]'s Articles
[Li, Zhi]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Mei, Jie]‘s Articles
[Liu, Sha]‘s Articles
[Li, Zhi]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Mtmr8 is essential for vasculature development in zebrafish embryos.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院水生生物研究所 - Feedback
Powered by CSpace