IHB OpenIR  > 鱼类生物学及渔业生物技术研究中心  > 期刊论文
Fish virus-induced interferon exerts antiviral function through Stat1 pathway
Yu, Fei-Fei; Zhang, Yi-Bing; Liu, Ting-Kai; Liu, Ying; Sun, Fan; Jiang, Jun; Gui, Jian-Fang; Gui, JF, Chinese Acad Sci, Grad Sch, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2010
Source PublicationMOLECULAR IMMUNOLOGY
ISSN0161-5890
Volume47Issue:14Pages:2330-2341
AbstractVirus-Induced interferons (IFNs) have been identified in various fish species and display antiviral activities similar to mammalian type I IFNs However apart from the mammalian IFN system the IFN signaling pathway remains largely unknown Using transient transfection and recombinant protein we are reporting in this study that a crucian carp (Carassius auratus L) IFN exhibits strong antiviral activity against grass carp hemorrhagic virus (GCHV) infection and also mediates Poly I C-Induced antiviral response which correlates with its ability to Induce a set of IFN-stimulated genes (ISGs) Strikingly overexpression of wild-type Stat1 increases the effects of IFN on both the expression of ISGs and the inhibition of virus infection whereas a dominant negative mutant of Stat1 (Stat1-Delta C) which lacks of the C-terminal transcriptional activation domain (TAD) inhibits the antiviral activity of IFN and reduces the expression of ISGs demonstrating that fish IFN induces the expression of ISGs and host antiviral response through Stat1 pathway reminiscent that of mammalian IFNs Significantly unlike mammalian type I IFNs recombinant fish IFN is able to upregulate IFN itself which is enhanced by overexpression of Stat1 but impaired by knockdown of Stat1 indicating a positive feedback loop in regulation of IFN itself These results provide strong evidence for the existence of an evolutionary conserved Stat1 pathway between fish and mammals which is indispensable for fish virus-induced IFN antiviral response (C) 2010 Elsevier Ltd All rights reserved
KeywordFish Virus Induced Interferon Stat1 Interferon Stimulated Genes (Isgs) Antiviral Response Jak Stat Signaling Pathway Positive Feedback Loop Recombinant Protein Transfection
Department[Yu, Fei-Fei; Zhang, Yi-Bing; Liu, Ting-Kai; Liu, Ying; Sun, Fan; Jiang, Jun; Gui, Jian-Fang] Chinese Acad Sci, Grad Sch, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Subject AreaBiochemistry & Molecular Biology ; Immunology
Funding Organization973 National Basic Research Program of China [2010CB126303]; 863 High Technology Research Program of China [2007AA09Z423]; National Natural Science Foundation of China [30671617 30871922]; National transgenic project [2009ZX08010-021B] ; 973 National Basic Research Program of China [2010CB126303]; 863 High Technology Research Program of China [2007AA09Z423]; National Natural Science Foundation of China [30671617 30871922]; National transgenic project [2009ZX08010-021B] ; 973 National Basic Research Program of China [2010CB126303]; 863 High Technology Research Program of China [2007AA09Z423]; National Natural Science Foundation of China [30671617 30871922]; National transgenic project [2009ZX08010-021B] ; 973 National Basic Research Program of China [2010CB126303]; 863 High Technology Research Program of China [2007AA09Z423]; National Natural Science Foundation of China [30671617 30871922]; National transgenic project [2009ZX08010-021B]
Indexed BySCI
Language英语
WOS IDWOS:000284304700005
Funding Organization973 National Basic Research Program of China [2010CB126303]; 863 High Technology Research Program of China [2007AA09Z423]; National Natural Science Foundation of China [30671617 30871922]; National transgenic project [2009ZX08010-021B] ; 973 National Basic Research Program of China [2010CB126303]; 863 High Technology Research Program of China [2007AA09Z423]; National Natural Science Foundation of China [30671617 30871922]; National transgenic project [2009ZX08010-021B] ; 973 National Basic Research Program of China [2010CB126303]; 863 High Technology Research Program of China [2007AA09Z423]; National Natural Science Foundation of China [30671617 30871922]; National transgenic project [2009ZX08010-021B] ; 973 National Basic Research Program of China [2010CB126303]; 863 High Technology Research Program of China [2007AA09Z423]; National Natural Science Foundation of China [30671617 30871922]; National transgenic project [2009ZX08010-021B]
Citation statistics
Cited Times:63[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/13569
Collection鱼类生物学及渔业生物技术研究中心_期刊论文
Corresponding AuthorGui, JF, Chinese Acad Sci, Grad Sch, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Yu, Fei-Fei,Zhang, Yi-Bing,Liu, Ting-Kai,et al. Fish virus-induced interferon exerts antiviral function through Stat1 pathway[J]. MOLECULAR IMMUNOLOGY,2010,47(14):2330-2341.
APA Yu, Fei-Fei.,Zhang, Yi-Bing.,Liu, Ting-Kai.,Liu, Ying.,Sun, Fan.,...&Gui, JF, Chinese Acad Sci, Grad Sch, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.(2010).Fish virus-induced interferon exerts antiviral function through Stat1 pathway.MOLECULAR IMMUNOLOGY,47(14),2330-2341.
MLA Yu, Fei-Fei,et al."Fish virus-induced interferon exerts antiviral function through Stat1 pathway".MOLECULAR IMMUNOLOGY 47.14(2010):2330-2341.
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