IHB OpenIR  > 淡水生态学研究中心  > 期刊论文
Microcystin Extracts Induce Ultrastructural Damage and Biochemical Disturbance in Male Rabbit Testis
Liu, Ying; Xie, Ping; Qiu, Tong; Li, Hui-Ying; Li, Guang-Yu; Hao, Le; Xiong, Qian; Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Beijing 100864, Peoples R China
2010
Source PublicationENVIRONMENTAL TOXICOLOGY
ISSN1520-4081
Volume25Issue:1Pages:9-17
AbstractIn the present research, the changes of ultrastructures and biochemical index in rabbit testis were examined after i.p. injection with 12.5 mu g/kg microcystin (MC) extracts. Ultrastructural observation showed widened intercellular junction, distention of mitochondria, endoplasmic reticulum, and Golgi apparatus. All these changes appeared at 1, 3, and 12 h, but recovered finally. In biochemical analyses, the levels of lipid peroxidation (MDA) and H2O2 increased significantly at 1 h, indicating MC-caused oxidative stress. Finally, H2O2 decreased to the normal levels, while MDA remained at high levels. The antioxidative enzymes (CAT, SOD, GPx, GST) and antioxidants (GSH) also increased rapidly at 1 h, demonstrating a quick response of the defense systems to the oxidative stress. Finally, the activity of CAT, SOD, and GPX recovered to the normal level, while the activity of GST and the concentration of GSH remained at a high level. This suggests that the importance of MCs detoxification by GST via GSH, and the testis of rabbit contained abundant GSH. The final recovery of ultrastructure and some biochemical indexes indicates that the defense systems finally succeeded in protecting the testis against oxidative damage. In conclusion, these results indicate that the MCs are toxic to the male rabbit reproductive system and the mechanism underlying this toxicity might to be the oxidative stress caused by MCs. Although the negative effects of MCs can be overcome by the antioxidant system of testis in this study, the potential reproductive risks of l should not be neglected because of their wide occurrence. (C) 2009 Wiley Periodicals, Inc. Environ Toxicol 25: 9-17. 2010.
KeywordGlutathione S-transferases
Department[Liu, Ying; Xie, Ping; Qiu, Tong; Li, Hui-Ying; Li, Guang-Yu; Hao, Le; Xiong, Qian] Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Beijing 100864, Peoples R China
Subject AreaEnvironmental Sciences ; Toxicology ; Water Resources
Funding OrganizationNational Basic Research Program of China [2008CB418101]; National Natural Science Foundation of China [30530170] ; National Basic Research Program of China [2008CB418101]; National Natural Science Foundation of China [30530170] ; National Basic Research Program of China [2008CB418101]; National Natural Science Foundation of China [30530170] ; National Basic Research Program of China [2008CB418101]; National Natural Science Foundation of China [30530170]
Indexed BySCI
Language英语
WOS IDWOS:000274715200002
Funding OrganizationNational Basic Research Program of China [2008CB418101]; National Natural Science Foundation of China [30530170] ; National Basic Research Program of China [2008CB418101]; National Natural Science Foundation of China [30530170] ; National Basic Research Program of China [2008CB418101]; National Natural Science Foundation of China [30530170] ; National Basic Research Program of China [2008CB418101]; National Natural Science Foundation of China [30530170]
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Cited Times:33[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/13554
Collection淡水生态学研究中心_期刊论文
Corresponding AuthorXie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Beijing 100864, Peoples R China
Recommended Citation
GB/T 7714
Liu, Ying,Xie, Ping,Qiu, Tong,et al. Microcystin Extracts Induce Ultrastructural Damage and Biochemical Disturbance in Male Rabbit Testis[J]. ENVIRONMENTAL TOXICOLOGY,2010,25(1):9-17.
APA Liu, Ying.,Xie, Ping.,Qiu, Tong.,Li, Hui-Ying.,Li, Guang-Yu.,...&Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Beijing 100864, Peoples R China.(2010).Microcystin Extracts Induce Ultrastructural Damage and Biochemical Disturbance in Male Rabbit Testis.ENVIRONMENTAL TOXICOLOGY,25(1),9-17.
MLA Liu, Ying,et al."Microcystin Extracts Induce Ultrastructural Damage and Biochemical Disturbance in Male Rabbit Testis".ENVIRONMENTAL TOXICOLOGY 25.1(2010):9-17.
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