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Antioxidant response in liver of the phytoplanktivorous bighead carp (Aristichthys nobilis) intraperitoneally-injected with extracted microcystins
Li, Li; Xie, Ping; Guo, Longgen; Xie, P, Huazhong Agr Univ, Coll Fisheries, Minist Educ, Key Lab Agr Anim Genet Breeding & Reprod, Wuhan 430070, Peoples R China
2010
Source PublicationFISH PHYSIOLOGY AND BIOCHEMISTRY
ISSN0920-1742
Volume36Issue:2Pages:165-172
AbstractThe worldwide occurrence of cyanobacterial blooms makes it necessary to perform environmental risk assessment procedures to monitor the effects of microcystins (MCs) on fish. Oxidative stress biomarkers are valuable tools in this regard. In the present study, phytoplanktivorous bighead carp (Aristichthys nobilis) were injected intraperitoneally (i.p.) with extracted MCs (mainly MC-RR and -LR) at two doses, 400 and 1,000 mu g kg(-1) bw, and antioxidant responses of the liver as biomarkers of oxygen-mediated toxicity were studied at 1, 3, 12, 24 and 48 h after injection. Contents of reactive oxygen species (ROS) and activities of antioxidant enzymes [catalase (CAT), superoxide dismutase (SOD), glutathione peroxide (GPX), and glutathione reductase (GR)] as well as glutathione S-transferase (GST) in the liver in both dose groups showed a biphasic change with an increase at initial 3 h followed by a decrease after injection, owing to the roles of the antioxidant system in eliminating excessive ROS and regenerating glutathione (GSH). The increased GST was probably due to the high transcription of cytosolic GST alpha and rho, suggesting the importance of MCs detoxification by GSH pathway. The stable GSH levels in liver may be explained by the high basic GSH concentration in liver, and/or an increased GSH synthesis, suggesting a high ability to detoxify MCs and to release associated high oxidative pressure in phytoplantivorous fish.
KeywordAntioxidant Response Bighead Carp Glutathione Liver Microcystins
Department[Li, Li; Xie, Ping] Huazhong Agr Univ, Coll Fisheries, Minist Educ, Key Lab Agr Anim Genet Breeding & Reprod, Wuhan 430070, Peoples R China; [Li, Li; Xie, Ping; Guo, Longgen] Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol China, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China
Subject AreaBiochemistry & Molecular Biology ; Fisheries ; Physiology
Funding OrganizationCAS ; National Natural Science Foundation of China [30225011] ; CAS ; National Natural Science Foundation of China [30225011] ; CAS ; National Natural Science Foundation of China [30225011] ; CAS ; National Natural Science Foundation of China [30225011]
Indexed BySCI
Language英语
WOS IDWOS:000277710800007
Funding OrganizationCAS ; National Natural Science Foundation of China [30225011] ; CAS ; National Natural Science Foundation of China [30225011] ; CAS ; National Natural Science Foundation of China [30225011] ; CAS ; National Natural Science Foundation of China [30225011]
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/13538
Collection淡水生态学研究中心_期刊论文
Corresponding AuthorXie, P, Huazhong Agr Univ, Coll Fisheries, Minist Educ, Key Lab Agr Anim Genet Breeding & Reprod, Wuhan 430070, Peoples R China
Recommended Citation
GB/T 7714
Li, Li,Xie, Ping,Guo, Longgen,et al. Antioxidant response in liver of the phytoplanktivorous bighead carp (Aristichthys nobilis) intraperitoneally-injected with extracted microcystins[J]. FISH PHYSIOLOGY AND BIOCHEMISTRY,2010,36(2):165-172.
APA Li, Li,Xie, Ping,Guo, Longgen,&Xie, P, Huazhong Agr Univ, Coll Fisheries, Minist Educ, Key Lab Agr Anim Genet Breeding & Reprod, Wuhan 430070, Peoples R China.(2010).Antioxidant response in liver of the phytoplanktivorous bighead carp (Aristichthys nobilis) intraperitoneally-injected with extracted microcystins.FISH PHYSIOLOGY AND BIOCHEMISTRY,36(2),165-172.
MLA Li, Li,et al."Antioxidant response in liver of the phytoplanktivorous bighead carp (Aristichthys nobilis) intraperitoneally-injected with extracted microcystins".FISH PHYSIOLOGY AND BIOCHEMISTRY 36.2(2010):165-172.
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