中国科学院水生生物研究所机构知识库
Advanced  
IHB OpenIR  > 淡水生态学研究中心  > 期刊论文
学科主题: Pharmacology & Pharmacy; Toxicology
题名: Transcriptional alteration of cytoskeletal genes induced by microcystins in three organs of rats
作者: Hao, Le ; Xie, Ping ; Ha, Huiying ; Li, Guangyu ; Xiong, Qian ; Wang, Qing ; Qiu, Tong ; Liu, Ying
通讯作者: Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Donghu S Rd 7, Wuhan 430072, Peoples R China
关键词: Microcystin ; Cytoskeletal ; Hepatotoxicity ; Tumor-promotion ; Neurotoxicity
刊名: TOXICON
发表日期: 2010
卷: 55, 期:7, 页:1378-1386
收录类别: SCI
部门归属: [Hao, Le; Xie, Ping; Ha, Huiying; Li, Guangyu; Xiong, Qian; Wang, Qing; Qiu, Tong; Liu, Ying] Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan 430072, Peoples R China; [Hao, Le; Li, Guangyu; Xiong, Qian] Chinese Acad Sci, Grad Sch, Wuhan 430072, Peoples R China
资助者: National Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30623001]
摘要: This study explored the mechanisms of toxicity of microcystins by measuring the transcription levels of nine cytoskeletal genes (actin, tubulin, vimentin, ezrin, radixin, moesin, MAP1b, tau, stathmin) in the liver, kidney and spleen of male Wistar rats treated with microcystins at a dose of 80 mu g MC-LReq kg(-1) bw. Microcystins disrupted the transcriptional homeostasis of cytoskeletal genes in these organs. Changes in the transcription of four genes (beta-actin, ezrin, radixin and tau) in liver, one gene (stathmin) in kidney, and one gene (radixin) in spleen were significantly correlated with the tissue concentration of microcystins. However, the influences on the transcription of most genes we studied were greater in the liver than in the kidney or spleen. The effects of microcystins on the transcription of cytoskeletal genes may explain some of the morphological and pathological changes observed in these organs and provide new information on the hepatotoxicity of these compounds. Additionally, transcriptional changes in tumor-associated cytoskeletal genes (ezrin, moesin and stathmin) that were observed in the present study provide a possible clue to the tumor-promoting potential of microcystins and their influences on the transcription of MAP1b and tau imply possible neurological toxicity of microcystins in vertebrates. (C) 2010 Published by Elsevier Ltd.
语种: 英语
WOS记录号: WOS:000277881900021
ISSN号: 0041-0101
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/13536
Appears in Collections:淡水生态学研究中心_期刊论文

Files in This Item: Download All
File Name/ File Size Content Type Version Access License
Transcriptional alteration of cytoskeletal genes induced by microcystins in three organs of rats.pdf(291KB)----开放获取--View Download

Recommended Citation:
Hao, Le; Xie, Ping; Ha, Huiying; Li, Guangyu; Xiong, Qian; Wang, Qing; Qiu, Tong; Liu, Ying.Transcriptional alteration of cytoskeletal genes induced by microcystins in three organs of rats,TOXICON,2010,55(7):1378-1386
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Hao, Le]'s Articles
[Xie, Ping]'s Articles
[Ha, Huiying]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Hao, Le]‘s Articles
[Xie, Ping]‘s Articles
[Ha, Huiying]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: Transcriptional alteration of cytoskeletal genes induced by microcystins in three organs of rats.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2016  中国科学院水生生物研究所 - Feedback
Powered by CSpace