IHB OpenIR  > 淡水生态学研究中心  > 期刊论文
Transcriptional alteration of cytoskeletal genes induced by microcystins in three organs of rats
Hao, Le; Xie, Ping; Ha, Huiying; Li, Guangyu; Xiong, Qian; Wang, Qing; Qiu, Tong; Liu, Ying; Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Donghu S Rd 7, Wuhan 430072, Peoples R China
2010
Source PublicationTOXICON
ISSN0041-0101
Volume55Issue:7Pages:1378-1386
AbstractThis study explored the mechanisms of toxicity of microcystins by measuring the transcription levels of nine cytoskeletal genes (actin, tubulin, vimentin, ezrin, radixin, moesin, MAP1b, tau, stathmin) in the liver, kidney and spleen of male Wistar rats treated with microcystins at a dose of 80 mu g MC-LReq kg(-1) bw. Microcystins disrupted the transcriptional homeostasis of cytoskeletal genes in these organs. Changes in the transcription of four genes (beta-actin, ezrin, radixin and tau) in liver, one gene (stathmin) in kidney, and one gene (radixin) in spleen were significantly correlated with the tissue concentration of microcystins. However, the influences on the transcription of most genes we studied were greater in the liver than in the kidney or spleen. The effects of microcystins on the transcription of cytoskeletal genes may explain some of the morphological and pathological changes observed in these organs and provide new information on the hepatotoxicity of these compounds. Additionally, transcriptional changes in tumor-associated cytoskeletal genes (ezrin, moesin and stathmin) that were observed in the present study provide a possible clue to the tumor-promoting potential of microcystins and their influences on the transcription of MAP1b and tau imply possible neurological toxicity of microcystins in vertebrates. (C) 2010 Published by Elsevier Ltd.
KeywordMicrocystin Cytoskeletal Hepatotoxicity Tumor-promotion Neurotoxicity
Department[Hao, Le; Xie, Ping; Ha, Huiying; Li, Guangyu; Xiong, Qian; Wang, Qing; Qiu, Tong; Liu, Ying] Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Wuhan 430072, Peoples R China; [Hao, Le; Li, Guangyu; Xiong, Qian] Chinese Acad Sci, Grad Sch, Wuhan 430072, Peoples R China
Subject AreaPharmacology & Pharmacy ; Toxicology
Funding OrganizationNational Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30623001] ; National Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30623001] ; National Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30623001] ; National Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30623001]
Indexed BySCI
Language英语
WOS IDWOS:000277881900021
Funding OrganizationNational Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30623001] ; National Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30623001] ; National Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30623001] ; National Basic Research Program of China (973 Program) [2008CB418101]; National Natural Science Foundation of China [30623001]
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/13536
Collection淡水生态学研究中心_期刊论文
Corresponding AuthorXie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Donghu S Rd 7, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Hao, Le,Xie, Ping,Ha, Huiying,et al. Transcriptional alteration of cytoskeletal genes induced by microcystins in three organs of rats[J]. TOXICON,2010,55(7):1378-1386.
APA Hao, Le.,Xie, Ping.,Ha, Huiying.,Li, Guangyu.,Xiong, Qian.,...&Xie, P, Chinese Acad Sci, Donghu Expt Stn Lake Ecosyst, State Key Lab Freshwater Ecol & Biotechnol China, Inst Hydrobiol, Donghu S Rd 7, Wuhan 430072, Peoples R China.(2010).Transcriptional alteration of cytoskeletal genes induced by microcystins in three organs of rats.TOXICON,55(7),1378-1386.
MLA Hao, Le,et al."Transcriptional alteration of cytoskeletal genes induced by microcystins in three organs of rats".TOXICON 55.7(2010):1378-1386.
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