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学科主题: Biology
题名: Olfactory receptor gene family evolution in stickleback and medaka fishes
作者: Chen Ming1, 2; Peng ZuoGang1; He ShunPing1
通讯作者: He, SP, Chinese Acad Sci, Lab Fish Phylogenet & Biogeog, Inst Hydrobiol, Wuhan 430072, Peoples R China
关键词: olfactory receptor ; positive selection ; binding site
刊名: SCIENCE CHINA-LIFE SCIENCES
发表日期: 2010-02-01
DOI: 10.1007/s11427-010-0025-4
卷: 53, 期:2, 页:257-266
收录类别: SCI
文章类型: Article
部门归属: [Chen Ming; Peng ZuoGang; He ShunPing] Chinese Acad Sci, Lab Fish Phylogenet & Biogeog, Inst Hydrobiol, Wuhan 430072, Peoples R China; [Chen Ming] Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: National Natural Science Foundation of China [30600062, 30530120]
类目[WOS]: Biology
研究领域[WOS]: Life Sciences & Biomedicine - Other Topics
摘要: Interaction of olfactory receptor (OR) genes with environmental odors is regarded as the first step of olfaction. In this study, OR genes of two fish, medaka (Oryzias latipes) and stickleback (Gasterosteus aculeatus), were identified and an evolutional analysis was conducted. The selection pressure of different TM regions and complete coding region were compared. Three TM regions (TM4, TM5 and TM6) were found to have higher average Ka/Ks values, which might be partly caused by positive selection as suggested by subsequent positive selection analysis. Further analysis showed that many PTSs overlap, or are adjacent to previously deduced binding sites in mammals. These results support the hypothesis that binding sites of fish OR genes may evolved under positive selection.
英文摘要: Interaction of olfactory receptor (OR) genes with environmental odors is regarded as the first step of olfaction. In this study, OR genes of two fish, medaka (Oryzias latipes) and stickleback (Gasterosteus aculeatus), were identified and an evolutional analysis was conducted. The selection pressure of different TM regions and complete coding region were compared. Three TM regions (TM4, TM5 and TM6) were found to have higher average Ka/Ks values, which might be partly caused by positive selection as suggested by subsequent positive selection analysis. Further analysis showed that many PTSs overlap, or are adjacent to previously deduced binding sites in mammals. These results support the hypothesis that binding sites of fish OR genes may evolved under positive selection.
关键词[WOS]: CODON-SUBSTITUTION MODELS ; PROTEIN-COUPLED RECEPTORS ; ODORANT-BINDING-SITE ; SEQUENCE ALIGNMENT ; NUCLEOTIDE SUBSTITUTION ; OVERDOMINANT SELECTION ; PHYLOGENETIC ANALYSIS ; MAXIMUM-LIKELIHOOD ; MOLECULAR-BASIS ; MOUSE
语种: 英语
WOS记录号: WOS:000276438100016
ISSN号: 1674-7305
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/13489
Appears in Collections:水生生物多样性与资源保护研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Lab Fish Phylogenet & Biogeog, Inst Hydrobiol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China

Recommended Citation:
Chen Ming; Peng ZuoGang; He ShunPing.Olfactory receptor gene family evolution in stickleback and medaka fishes,SCIENCE CHINA-LIFE SCIENCES,2010,53(2):257-266
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