IHB OpenIR  > 水生生物多样性与资源保护研究中心  > 期刊论文
High MHC DQB Variation and Asymmetric Allelic Distribution in the Endangered Yangtze Finless Porpoise, Neophocaena phocaenoides asiaeorientalis
Du, Hejun; Zheng, Jinsong; Wu, Min; Zhao, Qingzhong; Wang, Ding; Zheng, JS, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
2010
Source PublicationBIOCHEMICAL GENETICS
ISSN0006-2928
Volume48Issue:40304Pages:433-449
AbstractThe endangered Yangtze finless porpoise is found in the middle and lower reaches of the Yangtze River and its adjoining big lakes. To explore the major histocompatibility complex (MHC) genetic diversity and allelic distribution patterns across its range, we investigated variation at DQB exon 2. From 76 porpoises, we identified 18 DQB sequences. The freshwater Yangtze populations had much higher allelic diversity than marine populations. Among these freshwater populations, the middle-reach population had higher allelic diversity than the lower-reach population. The high DQB diversity level, relative to that of a neutral mtDNA locus, suggests that balancing selection is acting at the DQB gene and that rapid evolution and local positive selection play critical roles in generating and retaining high MHC diversity in the freshwater population. As the balancing selection might be driven by environmental pathogens, we suggest that maintaining MHC variation should be a high priority in the conservation and management of this endangered population, especially as an ex situ conservation strategy.
KeywordYangtze Finless Porpoise Dqb Genetic Variation Balancing Selection Conservation
Department[Du, Hejun; Zheng, Jinsong; Wu, Min; Zhao, Qingzhong; Wang, Ding] Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China; [Du, Hejun; Wu, Min] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Subject AreaBiochemistry & Molecular Biology ; Genetics & Heredity
Funding OrganizationNational Basic Research Program of China [2007CB411600]; Ministry of Science and Technology [2004DFB03000]; National Natural Science Foundation of China [30730018, 30570252] ; National Basic Research Program of China [2007CB411600]; Ministry of Science and Technology [2004DFB03000]; National Natural Science Foundation of China [30730018, 30570252] ; National Basic Research Program of China [2007CB411600]; Ministry of Science and Technology [2004DFB03000]; National Natural Science Foundation of China [30730018, 30570252] ; National Basic Research Program of China [2007CB411600]; Ministry of Science and Technology [2004DFB03000]; National Natural Science Foundation of China [30730018, 30570252]
Indexed BySCI
Language英语
WOS IDWOS:000277425600007
Funding OrganizationNational Basic Research Program of China [2007CB411600]; Ministry of Science and Technology [2004DFB03000]; National Natural Science Foundation of China [30730018, 30570252] ; National Basic Research Program of China [2007CB411600]; Ministry of Science and Technology [2004DFB03000]; National Natural Science Foundation of China [30730018, 30570252] ; National Basic Research Program of China [2007CB411600]; Ministry of Science and Technology [2004DFB03000]; National Natural Science Foundation of China [30730018, 30570252] ; National Basic Research Program of China [2007CB411600]; Ministry of Science and Technology [2004DFB03000]; National Natural Science Foundation of China [30730018, 30570252]
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Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/13481
Collection水生生物多样性与资源保护研究中心_期刊论文
Corresponding AuthorZheng, JS, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Du, Hejun,Zheng, Jinsong,Wu, Min,et al. High MHC DQB Variation and Asymmetric Allelic Distribution in the Endangered Yangtze Finless Porpoise, Neophocaena phocaenoides asiaeorientalis[J]. BIOCHEMICAL GENETICS,2010,48(40304):433-449.
APA Du, Hejun,Zheng, Jinsong,Wu, Min,Zhao, Qingzhong,Wang, Ding,&Zheng, JS, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China.(2010).High MHC DQB Variation and Asymmetric Allelic Distribution in the Endangered Yangtze Finless Porpoise, Neophocaena phocaenoides asiaeorientalis.BIOCHEMICAL GENETICS,48(40304),433-449.
MLA Du, Hejun,et al."High MHC DQB Variation and Asymmetric Allelic Distribution in the Endangered Yangtze Finless Porpoise, Neophocaena phocaenoides asiaeorientalis".BIOCHEMICAL GENETICS 48.40304(2010):433-449.
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