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学科主题: Biochemistry & Molecular Biology; Genetics & Heredity
题名: High MHC DQB Variation and Asymmetric Allelic Distribution in the Endangered Yangtze Finless Porpoise, Neophocaena phocaenoides asiaeorientalis
作者: Du, Hejun1, 2; Zheng, Jinsong1; Wu, Min1, 2; Zhao, Qingzhong1; Wang, Ding1
通讯作者: Zheng, JS, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
关键词: Yangtze finless porpoise ; DQB ; Genetic variation ; Balancing selection ; Conservation
刊名: BIOCHEMICAL GENETICS
发表日期: 2010-06-01
DOI: 10.1007/s10528-009-9327-2
卷: 48, 期:5-6, 页:433-449
收录类别: SCI
文章类型: Article
部门归属: [Du, Hejun; Zheng, Jinsong; Wu, Min; Zhao, Qingzhong; Wang, Ding] Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China; [Du, Hejun; Wu, Min] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
资助者: National Basic Research Program of China [2007CB411600]; Ministry of Science and Technology [2004DFB03000]; National Natural Science Foundation of China [30730018, 30570252]
类目[WOS]: Biochemistry & Molecular Biology ; Genetics & Heredity
研究领域[WOS]: Biochemistry & Molecular Biology ; Genetics & Heredity
摘要: The endangered Yangtze finless porpoise is found in the middle and lower reaches of the Yangtze River and its adjoining big lakes. To explore the major histocompatibility complex (MHC) genetic diversity and allelic distribution patterns across its range, we investigated variation at DQB exon 2. From 76 porpoises, we identified 18 DQB sequences. The freshwater Yangtze populations had much higher allelic diversity than marine populations. Among these freshwater populations, the middle-reach population had higher allelic diversity than the lower-reach population. The high DQB diversity level, relative to that of a neutral mtDNA locus, suggests that balancing selection is acting at the DQB gene and that rapid evolution and local positive selection play critical roles in generating and retaining high MHC diversity in the freshwater population. As the balancing selection might be driven by environmental pathogens, we suggest that maintaining MHC variation should be a high priority in the conservation and management of this endangered population, especially as an ex situ conservation strategy.
英文摘要: The endangered Yangtze finless porpoise is found in the middle and lower reaches of the Yangtze River and its adjoining big lakes. To explore the major histocompatibility complex (MHC) genetic diversity and allelic distribution patterns across its range, we investigated variation at DQB exon 2. From 76 porpoises, we identified 18 DQB sequences. The freshwater Yangtze populations had much higher allelic diversity than marine populations. Among these freshwater populations, the middle-reach population had higher allelic diversity than the lower-reach population. The high DQB diversity level, relative to that of a neutral mtDNA locus, suggests that balancing selection is acting at the DQB gene and that rapid evolution and local positive selection play critical roles in generating and retaining high MHC diversity in the freshwater population. As the balancing selection might be driven by environmental pathogens, we suggest that maintaining MHC variation should be a high priority in the conservation and management of this endangered population, especially as an ex situ conservation strategy.
关键词[WOS]: MAJOR HISTOCOMPATIBILITY COMPLEX ; POPULATION GENETIC-STRUCTURE ; CLASS-II LOCI ; BALANCING SELECTION ; SEQUENCE VARIATION ; NUCLEOTIDE SUBSTITUTION ; OVERDOMINANT SELECTION ; DELPHINAPTERUS-LEUCAS ; MICROSATELLITE LOCI ; RIVER DOLPHIN
语种: 英语
WOS记录号: WOS:000277425600007
ISSN号: 0006-2928
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/342005/13481
Appears in Collections:水生生物多样性与资源保护研究中心_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

Recommended Citation:
Du, Hejun; Zheng, Jinsong; Wu, Min; Zhao, Qingzhong; Wang, Ding.High MHC DQB Variation and Asymmetric Allelic Distribution in the Endangered Yangtze Finless Porpoise, Neophocaena phocaenoides asiaeorientalis,BIOCHEMICAL GENETICS,2010,48(5-6):433-449
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