Five experiments were conducted to investigate the effects of exogenous and endogenous factors on the growth and energy budgets of several aquaculture fishes. The exogenous factors included dietary protein resources and feeding frequency, and the experimental fish were gibel carp and Russian sturgeon; The endogenous factors included fish strains and exogenous gene, and the experimental fish were hybrid carp and its parents, and transgenic Huanghe carp and the controls. Five experiments are: Exogenous factors: 1. The effects of three dietary protein sources on growth and energy budgets of gibel carp; 2. The effects of partially replacement of fish meal by rapeseed meal with or without lysine supplement in the diets on growth and energy budgets of gibe1 carp; 3. The effects of feeding frequency on growth and energy budgets of Russian sturgeon; Endogenous factors: 1. Comparative energetics of Xingguo red carp, mirror splittered carp and hybrid carp; 2. Comparative energetics of F2 transgenic Huanghe carp and controls. The results are shown as the following: 1. Feeding rate, specific growth rate, food conversion efficiency of gibel carp fed diets with various protein sources were significantly different. The fish fed fish meal protein showed highest feeding rate, growth and feed utilization, and then soybean meal while the fish fed potato protein showed lowest. The tendency of the proportion of food energy channeled into growth and excretion were: fish meal > soybean meal > potato protein, that to metabolism (R) was: potato protein > soybean meal > fish meal, and that to fecal production (F) were: soybean meal > potato protein > fish meal. Specific dynamic action efficiency (as percentage of food energy, SDA%) were also significantly different: soybean meal > fish meal > potato protein. The SDA magnitude (J/g/d) showed positive linear relationship to FR and SGR_p while not strong to G. However, SDA efficiency did not show significant relationship to SGR_p, G or FR. 2. Feeding rate of gibel carp fed diets with the replacement of rapeseed meal supplemented with lysine was significantly higher than the other two groups. Growth and feed conversion efficiency of gibel carp fed on fish meal diet were significantly higher than the other two groups. Lysine supplementation had no effect on growth. The proportion of food energy deposited on growth of the fish fed on fish meal diet was highest, and that lost in metabolism and excretion were lower. Lysine supplementation in the diets with the inclusion of rapeseed meal had no significantly effects on the proportion of food energy channeled into growth, excretion and metabolism, but significantly decreased the proportion lost in feces. SDA magnitude has a negative linear relationship to SGR_p, G%, but did not show significant relationship to FR. SDA% showed a negative relationship to SGRp, G%, and did not show significant relationship to FR. 3. Feeding frequency had no significant effects on growth, feed utilization or energy budget of Russian sturgeon. 4. Feeding rate, growth and feed conversion efficiency of Xingguo red carp were significantly lower than mirror splitterred carp and hybrid carp, but not significant for the latter two. The proportion of food energy deposited in growth in Xingguo red carp were significantly lower than mirror splittered carp and hybrid carp. The proportion lost in metabolism were significantly higher than that in mirror splittered carp and hybrid carp. There was no significant difference between the fecal energy lost in three fishes. Rs of Xingguo red carp was highest, and hybrid carp was second and mirror splittered carp was lowest. SDA showed highest value in mirror splittered carp and lower in Xingguo red carp. 5. For transgenic Huanghe carp, feeding rate, growth and feed conversion efficiency of lipid and energy were significantly higher than that of the control. But feed conversion efficiency of dry matter and protein were significantly lower than the control. The proportion of food energy deposited into growth was significantly higher and that lost in metabolism was significantly lower than the controls. There was no significant difference in fecal energy and excretion between the two groups. Rs of transgenic Huanghe carp was significantly higher and SDA% was significantly lower than the controls.