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Cytological alterations in isolated hepatocytes from common carp (Cyprinus carpio L.) exposed to microcystin-LR
Li, XY; Liu, YD; Song, LR; Liu, YD, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China
2001
Conference Name5th International Conference on Toxic Cyanoacteria
Source PublicationENVIRONMENTAL TOXICOLOGY
Pages517-522
Conference DateJUL 15-20, 2001
Conference PlaceNOOSA, AUSTRALIA
DepartmentChinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China
AbstractMicrocystin-LR (MC-LR) is the most commonly encountered of the toxic cyclic peptide hepatotoxins occurring in China. It is a model compound for toxicological studies. In this study, the toxicity of MC-LR (50 and 500 mug/L) on isolated carp hepatocytes was determined and the ultrastructural alterations of cells induced by MC-LR were observed. The alterations noted when hepatocytes were exposed to 50 mug/L MC-LR were blebbing of cell membrane, shrinking and deformation of nuclei, vesiculation and transformation into concentric membrane whorls of RER, and swelling and rearrangement of the cytoskeleton. However, when the cells were exposed to 500 mug/L MC-LR, broken cell membranes, nuclei and cytoskeleton could be observed. These ultrastructural changes paralleled the pathological events, which lead to apoptosis or necrosis of hepatocytes. These results suggest that disruption of the cytoskeletal structures could account for the blebbing of cell membrane and apoptosis induced by MC-LR. (C) 2001 by John Wiley & Sons. Inc.
KeywordMicrocystin-lr Toxicity Hepatocyte Cyprinus Carpio L. Cytological Alteration
Indexed BySCI
Language英语
WOS IDWOS:000172521600011
Citation statistics
Cited Times:42[WOS]   [WOS Record]     [Related Records in WOS]
Document Type会议论文
Identifierhttp://ir.ihb.ac.cn/handle/342005/11837
Collection会议论文
Corresponding AuthorLiu, YD, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Li, XY,Liu, YD,Song, LR,et al. Cytological alterations in isolated hepatocytes from common carp (Cyprinus carpio L.) exposed to microcystin-LR[C],2001:517-522.
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