| 题名: | Cytological alterations in isolated hepatocytes from common carp (Cyprinus carpio L.) exposed to microcystin-LR |
| 作者: | Li, XY
; Liu, YD
; Song, LR
|
| 会议文集: | ENVIRONMENTAL TOXICOLOGY
|
| 会议名称: | 5th International Conference on Toxic Cyanoacteria
|
| 会议日期: | JUL 15-20, 2001
|
| 出版日期: | 2001
|
| 会议地点: | NOOSA, AUSTRALIA
|
| 关键词: | microcystin-LR
; toxicity
; hepatocyte
; Cyprinus carpio L.
; cytological alteration
|
| 通讯作者: | Liu, YD, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China
|
| 收录类别: | SCI
|
| 部门归属: | Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China
|
| 摘要: | Microcystin-LR (MC-LR) is the most commonly encountered of the toxic cyclic peptide hepatotoxins occurring in China. It is a model compound for toxicological studies. In this study, the toxicity of MC-LR (50 and 500 mug/L) on isolated carp hepatocytes was determined and the ultrastructural alterations of cells induced by MC-LR were observed. The alterations noted when hepatocytes were exposed to 50 mug/L MC-LR were blebbing of cell membrane, shrinking and deformation of nuclei, vesiculation and transformation into concentric membrane whorls of RER, and swelling and rearrangement of the cytoskeleton. However, when the cells were exposed to 500 mug/L MC-LR, broken cell membranes, nuclei and cytoskeleton could be observed. These ultrastructural changes paralleled the pathological events, which lead to apoptosis or necrosis of hepatocytes. These results suggest that disruption of the cytoskeletal structures could account for the blebbing of cell membrane and apoptosis induced by MC-LR. (C) 2001 by John Wiley & Sons. Inc. |
| 语种: | 英语
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| Citation statistics: |
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| 内容类型: | 会议论文
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| URI标识: | http://ir.ihb.ac.cn/handle/342005/11837
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| Appears in Collections: | 中科院水生所知识产出（2009年前）_会议论文
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| Cytological alterations in isolated hepatocytes from common carp (Cyprinus carpio L.) exposed to microcystin-LR.pdf（268KB） | -- | -- | 开放获取 | -- | View
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| Recommended Citation: | |
Li, XY; Liu, YD; Song, LR.Cytological alterations in isolated hepatocytes from common carp (Cyprinus carpio L.) exposed to microcystin-LR.见：.ENVIRONMENTAL TOXICOLOGY,,2001,517-522
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