| Cytological alterations in isolated hepatocytes from common carp (Cyprinus carpio L.) exposed to microcystin-LR | |
| Li, XY; Liu, YD; Song, LR; Liu, YD, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China | |
| 2001 | |
| Conference Name | 5th International Conference on Toxic Cyanoacteria |
| Source Publication | ENVIRONMENTAL TOXICOLOGY |
| Pages | 517-522 |
| Conference Date | JUL 15-20, 2001 |
| Conference Place | NOOSA, AUSTRALIA |
| Department | Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China |
| Abstract | Microcystin-LR (MC-LR) is the most commonly encountered of the toxic cyclic peptide hepatotoxins occurring in China. It is a model compound for toxicological studies. In this study, the toxicity of MC-LR (50 and 500 mug/L) on isolated carp hepatocytes was determined and the ultrastructural alterations of cells induced by MC-LR were observed. The alterations noted when hepatocytes were exposed to 50 mug/L MC-LR were blebbing of cell membrane, shrinking and deformation of nuclei, vesiculation and transformation into concentric membrane whorls of RER, and swelling and rearrangement of the cytoskeleton. However, when the cells were exposed to 500 mug/L MC-LR, broken cell membranes, nuclei and cytoskeleton could be observed. These ultrastructural changes paralleled the pathological events, which lead to apoptosis or necrosis of hepatocytes. These results suggest that disruption of the cytoskeletal structures could account for the blebbing of cell membrane and apoptosis induced by MC-LR. (C) 2001 by John Wiley & Sons. Inc. |
| Keyword | Microcystin-lr Toxicity Hepatocyte Cyprinus Carpio L. Cytological Alteration |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000172521600011 |
| Citation statistics | |
| Document Type | 会议论文 |
| Identifier | http://ir.ihb.ac.cn/handle/342005/11837 |
| Collection | 会议论文 |
| Corresponding Author | Liu, YD, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China |
| Recommended Citation GB/T 7714 | Li, XY,Liu, YD,Song, LR,et al. Cytological alterations in isolated hepatocytes from common carp (Cyprinus carpio L.) exposed to microcystin-LR[C],2001:517-522. |
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