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题名: Chronic toxicity and responses of several important enzymes in Daphnia magna on exposure to sublethal microcystin-LR
作者: Chen, W ; Song, LR ; Ou, DY ; Gan, NQ
会议文集: ENVIRONMENTAL TOXICOLOGY
会议名称: 6th International Conference on Toxic Cyanobacteria
会议日期: JUN 21-27, 2004
出版日期: 2005
会议地点: Bergen, NORWAY
关键词: Daphnia magna ; microcystin ; chronic toxicities ; ultrastructure ; enzyme
通讯作者: Song, LR, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
收录类别: SCI
部门归属: Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China; Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
摘要: In the current study, the toxicological mechanisms of microcystin-LR and its disadvantageous effects on Daphnia magna were examined. Survival rate, number of newborn, activity of several important enzymes [glutathione S-transferase (GST), lactate dehydrogenase (LDH), phosphatases, and glutathione], accumulated microcystins, and ultrastructural changes in different organs of Daphnia were monitored over the course of 21-day chronic tests. The results indicated that low concentrations of dissolved microcystin had no harmful effect on Daphnia. On the contrary, stimulatory effects were detected. In the presence of toxin at high dosage and for long-term exposure, GST and glutathione levels decreased significantly. The decreased enzyme activity in the antioxidant system probably was caused by detoxification reactions with toxins. And these processes of detoxification at the beginning of chronic tests may enable phosphatases in Daphnia magna to withstand inhibition by the toxins. At the same time, we also found that the LDH activity in test animals increased with exposure to microcystin-LR, indicating that adverse effects occurred in Daphnia. With microcystin given at a higher dosage or for a longer exposure, the effect on Daphnia magna was fatal. In the meantime, microcystin began to accumulate in Daphnia magna, and phosphatase activity started to be inhibited. From the ultrastructure results of cells in D. magna, we obtained new information: the alimentary canal may be the target organ affected by exposure of microcystins to D. magna. The results of the current study also suggested that the oxidative damage and PPI (protein phosphatase inhibition) mechanisms of vertebrates also are adapted to Daphnia. (c) 2005 Wiley Periodicals, Inc.
语种: 英语
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内容类型: 会议论文
URI标识: http://ir.ihb.ac.cn/handle/342005/11795
Appears in Collections:中科院水生所知识产出(2009年前)_会议论文

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Recommended Citation:
Chen, W; Song, LR; Ou, DY; Gan, NQ.Chronic toxicity and responses of several important enzymes in Daphnia magna on exposure to sublethal microcystin-LR.见:.ENVIRONMENTAL TOXICOLOGY,,2005,323-330
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