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学科主题: Pharmacology & Pharmacy; Toxicology
题名: The toxic effects of microcystin-LR on embryo-larval and juvenile development of loach, Misguruns mizolepis Gunthe
作者: Yongding Liu ; Lirong Song ; Xiaoyu Li ; Tongming Liu
通讯作者: Liu, YD, Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China
关键词: microcystin-LR ; Misguruns mizolepis Gunthe ; teratogenesis ; toxicity
刊名: TOXICON
发表日期: 2002
卷: 40, 期:4, 页:395-399
收录类别: SCI
部门归属: Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China
摘要: Microcystin-LR, a specific and potent hepatotoxin, was tested for its effects oil loach embryo-larval and juvenile development, The results of this study showed that loach embryos were more sensitive when exposed to microcystin-LR at a later than at an earlier stage of development, Juveniles were far less sensitive to MC-LR than were embryos and larvae. Mortality and developmental abnormality were proven to be dose-dependent and to be stage-specific sensitive. Among the abnormal changes noted were: pericardial edema and tubular heart, bradycardia, homeostasis, poor yolk resumption. small head, curved body and tail, and abnormal hatching, Liver and heart were the main targets of microcystin-LR toxicity. Ultrastructural analysis documented a complex set of sublethal effects of microcystin-LR on loach hepatocytes, chiefly including morphological alteration in nuclear and RER of loach liver cells. fit addition, microcystin-LR was lethal to loach juvenile in the subacute (7 days) exposure (LC50) = 593.3 mug/l). (C) 2002 Elsevier Science Ltd. All rights reserved.
WOS记录号: WOS:000173462600002
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内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/152342/9894
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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Yongding Liu; Lirong Song; Xiaoyu Li; Tongming Liu.The toxic effects of microcystin-LR on embryo-larval and juvenile development of loach, Misguruns mizolepis Gunthe,TOXICON,2002,40(4):395-399
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