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HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma
Jun Lin; Chang-sheng Deng; Jie Sun; Xian-gong Zheng; Xing Huang; Yan Zhou; Ping Xiong; Ya-ping Wang; Lin, J, Wuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China
2003
Source PublicationWORLD JOURNAL OF GASTROENTEROLOGY
Volume9Issue:3Pages:412-416
AbstractAIM: To probe into the genetic susceptibility of HLA-DRB1 alleles to esophageal carcinoma in Han Chinese in Hubei Province. METHODS: HLA-DRB1 allele polymorphisms were typed by polymerase chain reaction with sequence-specific primers (PCR-SSP) in 42 unrelated patients with esophageal cancer and 136 unrelated normal control subjects and the associated HLA-DRB1 allele was measured by nucleotide sequence analysis with PCR.SAS software was used in statistics. RESULTS: Allele frequency (AF) of HLA-DRB1*0901 was significantly higher in esophageal carcinoma patients than that in the normal controls (0.2500 vs0.1397, P=0.028, the odds ratio 2.053, etiologic fraction 0.1282). After analyzed the allele nucleotide sequence of HLA-DRB1*0901 which approachs to the corresponded exon 2 sequence of the allele in genebank. There was no association between patients and controls in the rested HLA-DRB1 alleles. CONCLUSION: HLA-DRB1*0901 allele is more common in the patients with esophageal carcinoma than in the healthy controls, which is positively associated with the patients of Hubei Han Chinese. Individuals carrying HLA-DRB1*0901 may be susceptible to esophageal carcinoma.
KeywordHla Class-ii
DepartmentWuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China; Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Immunol, Wuhan 430030, Peoples R China; Chinese Acad Sci, Inst Hydrobiol, State Key Lab, Wuhan 430077, Hubei, Peoples R China
Subject AreaGastroenterology & Hepatology
Indexed BySCI
Language英语
WOS IDWOS:000181745400006
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/9720
Collection期刊论文
Corresponding AuthorLin, J, Wuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China
Recommended Citation
GB/T 7714
Jun Lin,Chang-sheng Deng,Jie Sun,et al. HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2003,9(3):412-416.
APA Jun Lin.,Chang-sheng Deng.,Jie Sun.,Xian-gong Zheng.,Xing Huang.,...&Lin, J, Wuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China.(2003).HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma.WORLD JOURNAL OF GASTROENTEROLOGY,9(3),412-416.
MLA Jun Lin,et al."HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma".WORLD JOURNAL OF GASTROENTEROLOGY 9.3(2003):412-416.
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