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IHB OpenIR  > 中科院水生所知识产出(2009年前)  > 期刊论文
学科主题: Gastroenterology & Hepatology
题名: HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma
作者: Lin, J; Deng, CS; Sun, J; Zheng, XG; Huang, X; Zhou, Y; Xiong, P; Wang, YP
通讯作者: Lin, J, Wuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China
关键词: HLA CLASS-II
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2003-03-01
卷: 9, 期:3, 页:412-416
收录类别: SCI
文章类型: Article
部门归属: Wuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China; Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Immunol, Wuhan 430030, Peoples R China; Chinese Acad Sci, Inst Hydrobiol, State Key Lab, Wuhan 430077, Hubei, Peoples R China
WOS标题词: Science & Technology ; Life Sciences & Biomedicine
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
摘要: AIM: To probe into the genetic susceptibility of HLA-DRB1 alleles to esophageal carcinoma in Han Chinese in Hubei Province. METHODS: HLA-DRB1 allele polymorphisms were typed by polymerase chain reaction with sequence-specific primers (PCR-SSP) in 42 unrelated patients with esophageal cancer and 136 unrelated normal control subjects and the associated HLA-DRB1 allele was measured by nucleotide sequence analysis with PCR.SAS software was used in statistics. RESULTS: Allele frequency (AF) of HLA-DRB1*0901 was significantly higher in esophageal carcinoma patients than that in the normal controls (0.2500 vs0.1397, P=0.028, the odds ratio 2.053, etiologic fraction 0.1282). After analyzed the allele nucleotide sequence of HLA-DRB1*0901 which approachs to the corresponded exon 2 sequence of the allele in genebank. There was no association between patients and controls in the rested HLA-DRB1 alleles. CONCLUSION: HLA-DRB1*0901 allele is more common in the patients with esophageal carcinoma than in the healthy controls, which is positively associated with the patients of Hubei Han Chinese. Individuals carrying HLA-DRB1*0901 may be susceptible to esophageal carcinoma.
英文摘要: AIM: To probe into the genetic susceptibility of HLA-DRB1 alleles to esophageal carcinoma in Han Chinese in Hubei Province.
关键词[WOS]: HLA CLASS-II ; POLYMERASE-CHAIN-REACTION ; HUMAN-LEUKOCYTE ANTIGENS ; CYTOTOXIC T-LYMPHOCYTES ; COLORECTAL-CANCER ; CELL-CARCINOMA ; CARCINOEMBRYONIC-ANTIGEN ; PERIPHERAL-BLOOD ; GASTRIC-CANCER ; NORTHERN CHINA
语种: 英语
WOS记录号: WOS:000181745400006
ISSN号: 1007-9327
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ihb.ac.cn/handle/152342/9720
Appears in Collections:中科院水生所知识产出(2009年前)_期刊论文

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作者单位: 1.Wuhan Univ, Dept Gastroenterol, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Immunol, Wuhan 430030, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, State Key Lab, Wuhan 430077, Hubei, Peoples R China

Recommended Citation:
.HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma,WORLD JOURNAL OF GASTROENTEROLOGY,2003,9(3):412-416
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