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Transgene for growth hormone in common carp (Cyprinus carpio L.) promotes thymus development
GUO Qionglin; WANG Yaping; JIA Weizhang; ZHU Zuoyan; Zhu, ZY, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
2003
Source PublicationCHINESE SCIENCE BULLETIN
Volume48Issue:16Pages:1764-1770
AbstractThe transgenic carp were produced by micro-injection of CAgcGHc into the fertilized eggs. Observation of the thymus development between the transgenics and non-transgenic controls was carried out. The thymus of one-year-old transgenics F1 showed a great increase in both size and weight. The unilateral thymus of the transgenics weighed from 190 to 295 mg with average 218.6 mg, whereas the unilateral thymus of the controls weighed 20-81 mg with average 42.5 mg; i.e. the thymus weight in the transgenics was 5.14 fold over that in the controls. The index of thymus/body weight in the transgenics was 2.97 fold over the controls. Light microscopy observation indicated that the thymus of the transgenics; well developed with the thickened outer region and compactly arranged thymocytes, while the thymus in the controls were degenerating with the thinned outer region, scattered thymocytes and groups of fatty cells. Further analysis with the electron microscopy revealed that pro-liferous cells in the transgenics; were mainly small lymphocytes and no pathological changes were found. The results confirmed that the "All-fish" GH-transgene promotes thymus development and thymocyte proliferation, and retards thymus degeneration. The study has laid a foundation for further analysis of the immunobiological function in GH-transgenic carp.
KeywordAll-fish Growth Hormone Gene Growth Hormone (Gh) Transgenic Carp Thymus Immunity
DepartmentChinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Subject AreaMultidisciplinary Sciences
Indexed BySCI
WOS IDWOS:000185218200022
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/9656
Collection期刊论文
Corresponding AuthorZhu, ZY, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
GUO Qionglin,WANG Yaping,JIA Weizhang,et al. Transgene for growth hormone in common carp (Cyprinus carpio L.) promotes thymus development[J]. CHINESE SCIENCE BULLETIN,2003,48(16):1764-1770.
APA GUO Qionglin,WANG Yaping,JIA Weizhang,ZHU Zuoyan,&Zhu, ZY, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.(2003).Transgene for growth hormone in common carp (Cyprinus carpio L.) promotes thymus development.CHINESE SCIENCE BULLETIN,48(16),1764-1770.
MLA GUO Qionglin,et al."Transgene for growth hormone in common carp (Cyprinus carpio L.) promotes thymus development".CHINESE SCIENCE BULLETIN 48.16(2003):1764-1770.
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