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Growth hormone gene transfer in common carp
Gang Wu; Yonghua Sun; Zuoyan Zhu; Zhu, ZY, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hebei, Peoples R China
2003
Source PublicationAQUATIC LIVING RESOURCES
Volume16Issue:5Pages:416-420
AbstractThe first successful case of transgenic fish was achieved in 1984. It is in a model system that the integration and expression of recombinant human growth hormone (hGH) in host red common carp (Cyprinus carpio, red var.) have been thoroughly studied. Recently, the integration sites have been recovered and characterized. Compared with non-transgenic peers, hGH-transgenic fish are prior in dietary utilization and growth performance. In view of bio-safety and bio-ethics, an "all-fish" construct CAgcGH, grass carp growth hormone fused with common carp P-actin promoter, has been generated and transferred into Yellow River carp (C carpio, local strain in Yellow River) fertilized eggs. Under middle-scale trial, CAgcGH-transgenics show higher growth rate and food conversion efficiency than the controls, which is consistent to laboratory findings. To avoid the potential impact of transgenic fish on the environment, a sterile strain of transgenic triploid fish has been successfully produced. The "all-fish" transgenic common carp is also approved safe enough as daily food, according to a test based on the pathological principles of new medicines issued by the Ministry of Health of China. The "all-fish" transgenic common carp with growth enhancement is now ready for market, but looking for governmental authorization. (C) 2003 Editions scientifiques et medicales Elsevier SAS and Ifremer/IRD/Inra/Cemagref. All rights reserved.
KeywordGrowth Hormone Gene Transfer Growth Safety Common Carp
DepartmentChinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hebei, Peoples R China
Subject AreaFisheries ; Marine & Freshwater Biology
Indexed BySCI
WOS IDWOS:000186277100003
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/9626
Collection期刊论文
Corresponding AuthorZhu, ZY, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hebei, Peoples R China
Recommended Citation
GB/T 7714
Gang Wu,Yonghua Sun,Zuoyan Zhu,et al. Growth hormone gene transfer in common carp[J]. AQUATIC LIVING RESOURCES,2003,16(5):416-420.
APA Gang Wu,Yonghua Sun,Zuoyan Zhu,&Zhu, ZY, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hebei, Peoples R China.(2003).Growth hormone gene transfer in common carp.AQUATIC LIVING RESOURCES,16(5),416-420.
MLA Gang Wu,et al."Growth hormone gene transfer in common carp".AQUATIC LIVING RESOURCES 16.5(2003):416-420.
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