IHB OpenIR  > 期刊论文
Complete genome sequence of lymphocystis disease virus isolated from China
Zhang, QY; Xiao, F; Xie, H; Li, ZQ; Gui, HF; Zhang, QY, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan Ctr Dev Biol, Wuhan 430072, Peoples R China
2004
Source PublicationJOURNAL OF VIROLOGY
Volume78Issue:13Pages:6982-6994
AbstractLymphocystis diseases in fish throughout the world have been extensively described. Here we report the complete genome sequence of lymphocystis disease virus isolated in China (LCDV-C), an LCDV isolated from cultured flounder (Paralichthys olivaceus) with lymphocystis disease in China. The LCDV-C genome is 186,250 bp, with a base composition of 27.25% G+C. Computer-assisted analysis revealed 240 potential open reading frames (ORFs) and 176 nonoverlapping putative viral genes, which encode polypeptides ranging from 40 to 1,193 amino acids. The percent coding density is 67%, and the average length of each ORF is 702 bp. A search of the GenBank database using the 176 individual putative genes revealed 103 homologues to the corresponding ORFs of LCDV-1 and 73 potential genes that were not found in LCDV-1 and other iridoviruses. Among the 73 genes, there are 8 genes that contain conserved domains of cellular genes and 65 novel genes that do not show any significant homology with the sequences in public databases. Although a certain extent of similarity between putative gene products of LCDV-C and corresponding proteins of LCDV-1 was revealed, no colinearity was detected when their ORF arrangements and coding strategies were compared to each other, suggesting that a high degree of genetic rearrangements between them has occurred. And a large number of tandem and overlapping repeated sequences were observed in the LCDV-C genome. The deduced amino acid sequence of the major capsid protein (MCP) presents the highest identity to those of LCDV-1 and other iridoviruses among the LCDV-C gene products. Furthermore, a phylogenetic tree was constructed based on the multiple alignments of nine MCP amino acid sequences. Interestingly, LCDV-C and LCDV-1 were clustered together, but their amino acid identity is much less than that in other clusters. The unexpected levels of divergence between their genomes in size, gene organization, and gene product identity suggest that LCDV-C and LCDV-1 shouldn't belong to a same species and that LCDV-C should be considered a species different from LCDV-1.
KeywordChilo Iridescent Virus
DepartmentChinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan Ctr Dev Biol, Wuhan 430072, Peoples R China
Subject AreaVirology
Indexed BySCI
WOS IDWOS:000222153800031
Citation statistics
Cited Times:102[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/9470
Collection期刊论文
Corresponding AuthorZhang, QY, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan Ctr Dev Biol, Wuhan 430072, Peoples R China
Recommended Citation
GB/T 7714
Zhang, QY,Xiao, F,Xie, H,et al. Complete genome sequence of lymphocystis disease virus isolated from China[J]. JOURNAL OF VIROLOGY,2004,78(13):6982-6994.
APA Zhang, QY,Xiao, F,Xie, H,Li, ZQ,Gui, HF,&Zhang, QY, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan Ctr Dev Biol, Wuhan 430072, Peoples R China.(2004).Complete genome sequence of lymphocystis disease virus isolated from China.JOURNAL OF VIROLOGY,78(13),6982-6994.
MLA Zhang, QY,et al."Complete genome sequence of lymphocystis disease virus isolated from China".JOURNAL OF VIROLOGY 78.13(2004):6982-6994.
Files in This Item:
File Name/Size DocType Version Access License
Complete genome sequ(127KB) 开放获取--View Application Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, QY]'s Articles
[Xiao, F]'s Articles
[Xie, H]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, QY]'s Articles
[Xiao, F]'s Articles
[Xie, H]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, QY]'s Articles
[Xiao, F]'s Articles
[Xie, H]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Complete genome sequence of lymphocystis disease virus isolated from China.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.