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Positive selection on multiple antique allelic lineages of transferrin in the polyploid Carassius auratus
Lin Yang and Jian-Fang Gui; Gui, JF, Chinese Acad Sci, Inst Hydrobiol, Wuhan Ctr Dev Biol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China
2004
Source PublicationMOLECULAR BIOLOGY AND EVOLUTION
Volume21Issue:7Pages:1264-1277
AbstractTransferrin polymorphism has been studied in the polyploid Carassius auratus by cloning and sequence analysis of cDNAs from its three subspecies C. auratus gibelio, C. auratus auratus, and C. auratus cuvieri. DNA polymorphism of extremely high extent was shown for the transferrin gene by the 248 segregation sites among coding region sequences of its alleles. The deduced amino acid sequences of the transferrin alleles showed variable theoretical physicochemical parameters, which might constitute molecular basis for their electrophoretic heterogeneity. Positive selection was inferred by the replacement/synonymous ratios larger than 1 in partial allelic lineages which was subsequently confirmed by likelihood simulation under neutral or selection models. Furthermore, the correspondent sites to these selected codons were collectively located at two planes in the crystallographic structure of rabbit transferrin, which suggested that the rapid evolution of C. auratus transferrin might correlate to its adaptation to variable environmental elements such as oxygen pressure. The minimal 26 recombination events were detected among coding sequences of C. auratus transferrin, with partial mosaic sequences and breakpoints identified by identity scanning and information site analyses. Phylogenetic analyses revealed multiple antique allelic lineages of transferrin, which was estimated to diverge fifteen to twenty MYA. All these features strongly suggested the role of balancing selection in long persistence of high transferrin polymorphism in C. auratus. Furthermore, owing to its particular evolutionary backgrounds, the silver crucian carp might possess a distinctive balancing selection mechanism.
KeywordTransferrin Polymorphism Positive Selection Balancing Selection Allele Recombination Carassius Auratus
DepartmentChinese Acad Sci, Inst Hydrobiol, Wuhan Ctr Dev Biol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China; Wuhan Univ, Coll Life Sci, Modern Virol Res Ctr, Wuhan 430072, Peoples R China
Subject AreaBiochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
Indexed BySCI
WOS IDWOS:000222334300011
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/9466
Collection期刊论文
Corresponding AuthorGui, JF, Chinese Acad Sci, Inst Hydrobiol, Wuhan Ctr Dev Biol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China
Recommended Citation
GB/T 7714
Lin Yang and Jian-Fang Gui,Gui, JF, Chinese Acad Sci, Inst Hydrobiol, Wuhan Ctr Dev Biol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China. Positive selection on multiple antique allelic lineages of transferrin in the polyploid Carassius auratus[J]. MOLECULAR BIOLOGY AND EVOLUTION,2004,21(7):1264-1277.
APA Lin Yang and Jian-Fang Gui,&Gui, JF, Chinese Acad Sci, Inst Hydrobiol, Wuhan Ctr Dev Biol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China.(2004).Positive selection on multiple antique allelic lineages of transferrin in the polyploid Carassius auratus.MOLECULAR BIOLOGY AND EVOLUTION,21(7),1264-1277.
MLA Lin Yang and Jian-Fang Gui,et al."Positive selection on multiple antique allelic lineages of transferrin in the polyploid Carassius auratus".MOLECULAR BIOLOGY AND EVOLUTION 21.7(2004):1264-1277.
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