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Discovery and characterization of two types of liver-expressed antimicrobial peptide 2 (LEAP-2) genes in rainbow trout
Yong-An Zhang; Jun Zou; Chin-I Chang; Christopher J. Secombes; Secombes, CJ, Univ Aberdeen, Dept Zool, Scottish Fish Immunol Res Ctr, Zool Bldg,Tillydrone Ave, Aberdeen AB24 2TZ, Scotland
2004
Source PublicationVETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
Volume101Issue:3-4Pages:259-269
AbstractThe sequences and gene organisation of two LEAP-2 molecules (LEAP-2A and LEAP-2B) from rainbow trout, Oncorhynchus mykiss are presented. Both genes consist of a 3 exon/2 intron structure, with exon sizes comparable to known mammalian genes. LEAP-2A notably differs from LEAP-2B in having larger introns and a larger 3'UTR. The predicted proteins contain a signal peptide and prodomain, followed by a mature peptide of 41 aa containing four conserved cysteines. The RXXR cleavage site to release the mature peptide was also conserved. Both genes were found to be constitutively expressed in the liver, with expression in the intestine, and to a lesser extent the skin, evident after bacterial challenge. (C) 2004 Elsevier B.V. All rights reserved.
KeywordLeap-2 Antimicrobial Peptide Liver Rainbow Trout Teleost
DepartmentUniv Aberdeen, Dept Zool, Scottish Fish Immunol Res Ctr, Aberdeen AB24 2TZ, Scotland; Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China; Fisheries Res Inst, Chilung, Taiwan
Subject AreaImmunology ; Veterinary Sciences
Indexed BySCI
WOS IDWOS:000224154600014
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Document Type期刊论文
Identifierhttp://ir.ihb.ac.cn/handle/152342/9418
Collection期刊论文
Corresponding AuthorSecombes, CJ, Univ Aberdeen, Dept Zool, Scottish Fish Immunol Res Ctr, Zool Bldg,Tillydrone Ave, Aberdeen AB24 2TZ, Scotland
Recommended Citation
GB/T 7714
Yong-An Zhang,Jun Zou,Chin-I Chang,et al. Discovery and characterization of two types of liver-expressed antimicrobial peptide 2 (LEAP-2) genes in rainbow trout[J]. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,2004,101(3-4):259-269.
APA Yong-An Zhang,Jun Zou,Chin-I Chang,Christopher J. Secombes,&Secombes, CJ, Univ Aberdeen, Dept Zool, Scottish Fish Immunol Res Ctr, Zool Bldg,Tillydrone Ave, Aberdeen AB24 2TZ, Scotland.(2004).Discovery and characterization of two types of liver-expressed antimicrobial peptide 2 (LEAP-2) genes in rainbow trout.VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,101(3-4),259-269.
MLA Yong-An Zhang,et al."Discovery and characterization of two types of liver-expressed antimicrobial peptide 2 (LEAP-2) genes in rainbow trout".VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 101.3-4(2004):259-269.
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