| Molecular cloning of the viperin gene and its promoter region from the mandarin fish Siniperca chuatsi | |
| B.J. Sun; P. Nie; Nie, P, Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China | |
| 2004 | |
| Source Publication | VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
 |
| Volume | 101Issue:3-4Pages:161-170 |
| Abstract | A viperin gene has been cloned from the mandarin fish (Siniperca chuatsi). From the first transcription initiation site, the mandarin fish viperin gene extends 3163 nucleotides to the end of the 3' untranslated region, and it contains six exons and five introns. The open reading frame of the viperin transcript has 1062 nucleotides which encode a 354 amino acid peptide. The amino acid sequence of mandarin fish viperin shows high identities with its homologues in teleosts and mammals except for the first 70 amino acids. A characteristic feature in the viperin promoter region was the presence of five putative ICSBP (IRF8) binding sites and one IRFI binding site. The viperin gene expressed mainly in lymphoid tissues before stimulation, but its expression can be examined in almost all the organs investigated after stimulation with virus or Poly I:C. The expression pattern and promoter sequence may be considered as the indirect evidence that the transcription of viperin is regulated by interferons or interferon induced genes. (C) 2004 Elsevier B.V. All rights reserved. |
| Keyword | Viperin Gene Organization Promoter Mandarin Fish Chinese Perch Siniperca Chuatsi |
| Department | Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China; Chinese Acad Sci, Lab Fish Dis, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China |
| Subject Area | Immunology ; Veterinary Sciences |
| Indexed By | SCI |
| WOS ID | WOS:000224154600004 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ihb.ac.cn/handle/152342/9416 |
| Collection | 期刊论文 |
| Corresponding Author | Nie, P, Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China |
| Recommended Citation GB/T 7714 | B.J. Sun,P. Nie,Nie, P, Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China. Molecular cloning of the viperin gene and its promoter region from the mandarin fish Siniperca chuatsi[J]. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,2004,101(3-4):161-170. |
| APA | B.J. Sun,P. Nie,&Nie, P, Chinese Acad Sci, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China.(2004).Molecular cloning of the viperin gene and its promoter region from the mandarin fish Siniperca chuatsi.VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY,101(3-4),161-170. |
| MLA | B.J. Sun,et al."Molecular cloning of the viperin gene and its promoter region from the mandarin fish Siniperca chuatsi".VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 101.3-4(2004):161-170. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Molecular cloning of（789KB） | 开放获取 | -- | View Application Full Text | |||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment